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Metamorphic - Europe PMC

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Last Updated: 23 May 2022

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METRECoP: a methodology for identifying METamorphic RElations through Constraint Programming

Metamorphic Testing is a testing design approach that results in “follow-up” test cases from existing ones, as well as the use of metamorphic relations. These MRs encode information about the problem being solved by the device under test. We recommend a refinement of IMT that uses mature constraint programming languages to formalize MRs and automate the generation of test cases. The investigation of the initial cases, the MRs' manufacture, and the use of the MRs to produce a comprehensive test suite are covered in this article.

Source link: https://europepmc.org/article/PPR/PPR492852


Design and discovery of metamorphic proteins.

Metamorphic proteins are single amino acid chains that convert between multiple, highly diverse native structures, many with specific functions. Many additional metamorphic proteins have been identified since the discovery of the first metamorphic proteins in the early 2000s, and it was estimated that up to 4% of proteins in the PDB can switch folds. The discovery of novel metamorphic proteins in nature would facilitate tissue diagnosis of fold-switching proteins involved in human pathology research and improve the design of protein-based therapies.

Source link: https://europepmc.org/article/MED/35561475


The two-body problem: Proprioception and motor control across the metamorphic divide.

Evolution has engineered flies to fly into adulthood via multiple stages, like a rocket being launched into space. The fly larva is a soft hydraulic tube that can crawl to find food and avoid predators. The metamorphic divide also provides the possibility for comparative analysis of neural circuits. Here, we review recent findings in larval and adult Drosophila to determine the neural pathways of proception and motor control. We conclude with discussing emerging avenues for comparative investigation of neural circuit architecture in the fly and other animal species.

Source link: https://europepmc.org/article/MED/35512562

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions