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Multiple intracellular pathways that contribute to these effects have been uncovered by research into the role of extracellular signal processing processes in E2 action, but few have doubted that extracellular signaling pathways can play a role in E2 action. Here, we investigated the effects of hippocampal MMP-9 stimulation on E2-induced spatial and object recognition memory consolidation. An MMP-9 inhibitor injection into the dorsal hippocampus of ovariectomized female mice's dorsal hippocampus prevented the growth of E2 in object placement and object recognition memory, supporting a role for MMP-9 in estrogenic control of memory consolidation. The activity of dorsal hippocampal MMP-9 without changing its protein expression was also increasing quickly, providing more insight into hippocampal E2/MMP-9 interactions. These findings, together, show that E2 regulates MMP-9 to modulate hippocampal memory, and highlight the need to investigate extracellular differentiation.
Source link: https://doi.org/10.1016/j.psyneuen.2022.105773
MT1-MMP is a key player in promoting tumor cell migration by degrading the extracellular matrix to open a path for migration. According to KIF3A and KIF13A's collaboration to transport the same MT1-MMP-containing vesicles from the trans-Golgi to the endosomes, KIF3A and KIF13A coordinate to move the vesicle from the endosome to the plasma membrane, and KIF13A alone transports the vesicle from the endosome to the plasma membrane, according to live-cell imaging studies. We have established a special interplay between three KIFs to control leading edge localization of MT1-MMP and MT1-MMP-dependent cancer cell invasion in the United Kingdom.
Source link: https://doi.org/10.1016/j.matbio.2022.01.004
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