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One way mGluRs can influence synaptic plasticity is by limiting the local translation of AMPA receptor trafficking proteins by eukaryotic elongation factor 2. The affiliation of several genetic variants within the mGluR-eEF2-AMPAR pathway and alcohol use behavior in the Grady Trauma Project, an independent sample of adults living in Atlanta, Georgia, including individual variations in GRM1, GRM5, EEF2, MTOR, GRIA1, and HOMER2, has been replicated. Multiple test results and predicted increased alcohol consumption and related problems were found in the GTP, according to gene-based findings.
Source link: https://doi.org/10.1038/tp.2015.70
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