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Cell death was caused cell death by decreasing mGlu_5 expression in HCC cells and increased mGlu_5 expression in hepatic cells. MGlu_5 overexpression or knockdown on MMS-induced DNA damage has shown that cell death is a result of mGlu_5 expression's differentiation. This research shows that mGlu_5 inhibition may work synergistically with HCC chemotherapeutics with minimal side effects, which may be helpful in the treatment of patients with HCC. Both HCC cells and hepatic cells died as a result of Ca2+ overload and MAPKs activation, resulting in DNA damage and cell death. In comparison, mGlu_5 expression in HCC cells was downregulated, as a result of chemotherapeutics, and inhibition of mGlu_5 exacerbated cytotoxicity of chemotherapeutics, but the agonist of mGlu_5 reversed this reaction.
Source link: https://doi.org/10.1038/s41417-022-00465-2
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