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Metabotropic glutamate receptors are family C G-protein-coupled receptors. Spectroscopic studies show that signalling is a vibrant procedure, in which large conformational modifications underlie the transmission of signals from the extracellular Venus flytraps to the G protein-coupling domains-- the 7-transmembrane domain names-- in the membrane. Our outcomes show that agonist binding at the Venus flytraps results in a compaction of the intersubunit dimer interface, consequently bringing the cysteine-rich domain names into close distance.
Source link: https://www.osti.gov/biblio/1503075
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