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Metabolomics - Zenodo

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Last Updated: 08 June 2022

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Metabolomics and health: from nutritional crops and plant-based pharmaceuticals to profiling of human biofluids

"Metabomics has emerged as one of the fastest growing segments of “-omics” technologies over the past decade. ' To aid early disease biomarker discovery and predict individual responses to drug therapy, metabolomic analysis of human biofluids is used in clinical research to distinguish between physiological and pathological state in humans. metabolomics may be used to protect human health by improving the nutritional quality of crops and accelerating plant-derived bioactive leads discovery by disease diagnostics, or by increasing the therapeutic efficacy of drugs through a more personalized approach. Here, we investigate the potential use of metabolomics profiling in crop growth, medicinal plants use, and, ultimately, in the diagnosis, and management of complex diseases.

Source link: https://zenodo.org/record/6597363


Metabolomics: towards acceleration of antibacterial plant-based leads discovery

Plant secondary metabolites have a wide and not completely discovered potential, making plants a rich source of drug leads. From this angle, metabolomics is vital in understanding cell function changes when bacteria are subjected to metabolic stress caused by treatment with secondary metabolites that inhibit their growth. Physiology has been used in this research to show bacteria response to plant-derived secondary metabolites. Metabolomics may be a way to identify antibacterial plant-based bioactive secondary metabolites and their mechanism of action. Hence, the benefits of a metabolomic screening for antimicrobials from plants, as well as investigating the target points in bacteria metabolism and discovery of natural antimicrobial resistance are discussed herein. Antimicrobial molecules are easily identified in complex plant mixtures by basic chemometrics and molecular networking.

Source link: https://zenodo.org/record/6597211


1H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer

"Prostate cancer is the second most common disease and the fifth cause of cancer-related suicide in men worldwide. " Here, we used NMR-based metabolomics on a large number of urine samples from PC and benign prostate hyperplasia patients to determine the molecular causes of the disease's molecular basis. In the urine of PC people, metabolites from such pathways were reduced, largely supporting the argument that PC minimizes nitrogen and carbon pollution in order to optimize their use in anabolic processes that promote cancer cell growth," we discovered out.

Source link: https://zenodo.org/record/3935677

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions