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Metabolite Mass Spectrometry - Wiley Online Library

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Last Updated: 13 May 2022

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Identification of metabolites of Ginkgolide B in vivo and in vitro using ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry

Ginkgolide B is a dietary diterpene with multiple pharmacological functions. However, new ginkgolide B research on ginkgolide B is not comprehensive. The current research looked at the metabolic profiles of ginkgolide B in vivo and in vitro using ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry. A novel data processing method was used as an assistant instrument to measure and identify the various metabolites in ginkgolide B. To blank samples, a total of 53 different metabolites of ginkgolide B were found. In vivo and in vitro, a method for the analysis of other diterpene metabolic products was also established.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jssc.202101016


New steps in acute coronary syndrome and antihyperlipidemic treatment: Determination of statins and metabolites by liquid chromatography tandem mass spectrometry

Patients with unstable angina pectoris, STelevation myocardial infarction, or non-STelevation myocardial infarction were measured by the validated method in a total of 210 patients with unstable angina pectoris, STelevation myocardial infarction, or nonSTelevation myocardial infarction. According to a survey conducted by USAP, STEMI, and NSTEMI, treatment adherence rates were 22. 1, 23. 5, and 41. 2% for atorvastatin, 36. 1, 40. 2, and 67. 1% for rosuvastatin. Our findings point to poor patient compliance with statin therapy in the sample population.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/bmc.5390


Enantioselectivity and residue analysis of cycloxaprid and its metabolite in the pile and fermentation processing of Puer tea by ultraperformance liquid chromatography–high‐resolution mass spectrometry

Abstract The chemistry of cyclopropaprid enantiomers and metabolites are investigated by ultraperformance liquid chromatography-high-resolution mass spectrometry during raw and ripen Puer tea processing. The half-lives of 1R, 2S, cycleoxaprid, and 1S are 1. 68 h and 1. 77 h during raw Puer tea processing, but the residue is still present even if it is over 730 days. The quantities of metabolite in raw tea are greater than in ripen tea; the terminal residues are still present in ripen tea until 730 days after raw tea; The degration result shows cycloselectivity of cycloxaprid in raw or ripen Puer tea processing.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/fsn3.2901


Simultaneous determination of pyflubumide and its metabolite in vegetables and fruits by ultrahigh performance liquid chromatography‐tandem mass spectrometry

For simultaneously monitoring the novel acaricide pyflubumide and its metabolite in vegetables and fruits, a simple and cost-effective analytical technique based on ultrahigh-performance liquid chromatography-tandem mass spectrometry was developed and validated. Both compounds were below the maximum residue values of pyflubumide in foods developed by Japan and South Korea, which was well below the maximum residue limits. Pyflubumide and its metabolite were quickly detected in real samples, and it was found to be robust and effective for routinely testing both pyflubumide and its metabolite in vegetable and fruit samples.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jssc.202200027

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions