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"Abstract Phenanthrene is the first polycyclic aromatic hydrocarbon containing a bay region, which is closely linked to carcinogenicity. " We have suggested that the measurement of phenanthrene metabolites in human urine could be used to determine interindividual differences in PAH metabolism activation and detoxification, as well as cancer susceptibility in smokers and other exposed individuals. Anti-PheT is the most valuable product of the phenanthrene's diol epoxide metabolic activation pathway. We have extended our carcinogen metabolite phenotyping scheme by inventing a method for measuring phenanthrol levels in human urine in this study. Phenanthrols, for example, are classified as detoxification agents. Means of 1-HOPhe and 3-HOPhe were higher than those of 2-HOPhe and 4-HOPhe, respectively, in smokers. There were no significant differences between the phenanthrol levels in smokers and non-smokers. ".
Source link: https://doi.org/10.1158/1055-9965.2167.13.12
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