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For reversing the tumor immunosuppressive microenvironment, a sub-Nm MnFe 2 O 4 conjugated with dichloroacetic acid nanoparticle is introduced. The ultrathin MnFe 2 O 4 -DCA nanoparticle can easily penetrate mitochondria and oxygenate oxygen, improving DCA's bioactivity to control glucose metabolism and reducing lactate production ca. The simultaneous regulation of glucose metabolism and ATP catabolism in tumor microenvironment has boosted immune ATP level and decreased immunosuppressive adenosine and lactate levels, ultimately increasing dendritic cell maturation, enhanced cytotoxic T lymphocyte response, and improved cancer immunotherapy sensitivity.
Source link: https://europepmc.org/article/MED/35462304
A remarkablely more in-depth analysis of tumor metabolism in tumorigenesis, tumor formation, metastasis, and prognosis has been achieved in recent years. The general heterogeneity of tumor tissue is the determining factor that influences tumor treatment's outcome. A key research hotspot has been using the tumor microenvironment's metabolic characteristics to identify and treat cancer. This review examines systematically the effects of metabolism on tumor cells and effector cells, as well as recent research findings on metabolic effects in tumor cells and effector cells.
Source link: https://europepmc.org/article/MED/35454171
Tumor-associated macrophages are a key cellular component of the tumor microenvironment. TAMs from mice with liver metastatic tumors were determined by single-cell transcriptome analysis. Increased purine metabolism is a characteristic of TAMs with pro-tumor and terminal differentiation phenotypes, according to integrative research and validation studies. Human TAMs are remarkably heterogeneous, similar to mouse TAMs. Human TAMs with elevated purine metabolism have a pro-tumor phenotype and relationship with inadequate therapeutic success to immune checkpoint blockade.
Source link: https://europepmc.org/article/MED/35385733
Within the breast cancer microenvironment, highly abundant cancer-associated adipocytes interact with cancer cells by secretly releasing a variety of adipocytokines and metabolites. Obesity is also a significant factor in this manner, where the accumulation of adipose tissue next to tumor tissue is related to breast cancer's rising incidence, progression, and metastasis. Hence, preventing this association between breast cancer cells and dysfunctional adipose tissue could lead to a promising therapeutic strategy against breast cancer.
Source link: https://europepmc.org/article/MED/35248624
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