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Metabolism - U.S. Department of Veterans Affairs

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Last Updated: 15 June 2022

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Energy Metabolism in Gynecological Cancers: A Scoping Review.

"Determining energy requirements is vital for optimizing diet interventions in pro-catabolic conditions such as cancer. " Gynecological cancer is one of the most common cancers in women, but there is no evidence focusing on the effects of its hormonal causes. This paper was designed to look at the literature pertaining to energy metabolism in gynecological cancers. We were particularly interested in finding out the prevalence of energy metabolism abnormalities, methodological approaches used to analyze energy metabolism, and the medical implications of incorrectly estimating energy needs. Any stage of gynecological cancer or the type of therapy were considered in studies investigating how energy metabolism in adults was determined by accurate methods. The definition of energy metabolism abnormalities differed among studies. Hypermetabolism was more common in ovarian compared to cervical cancer in one of these studies. Overall, commonly used figures may not accurately predict energy expenditures in gynecological cancers, which may have a dramatic effect on nutritional evaluation and intervention. ".

Source link: https://doi.org/10.3390/ijerph19116419


Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori-induced inflammation-driven gastric carcinogenesis.

"We find that H. pylori increased gastric injury in INS-GAS mice under iron-deficient conditions. " When H. pylori-infected mice were treated with DCA, the severity of gastric injury was aggravated, and DCA enhanced translocation of the H. pylori oncoprotein CagA into host cells, as shown by in vitro. Conversely, bile acid sequestration attenuated H. pylori-induced injury in the setting of iron deficiency. In a large human population, we investigated the connection between bile acid sequestrant use and gastric cancer risk. To bring these findings to human populations. And, the occurrence of carcinogenic lesions in humans was similar to that of the bile acid receptor transmembrane G protein-coupled bile acid receptor 5's. These results show that elevated H. pylori-induced injury in the context of iron deficiency is tightly linked to increased bile acid metabolism, which may contribute to gastric carcinogenesis. ".

Source link: https://doi.org/10.1172/JCI147822

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions