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Global climate change is caused by high amounts of anthropogenic CO 2 emissions. If this pattern of rising emissions continues, it will lead to further climate change with serious consequences for the human race. Global biosustainability is jeopardizing global biosustainability, due in large part to the increasing accumulation of solid waste within the linear economy model. With increased feedstock flexibility and selectivity, Microbial gas fermentation provides an exciting opportunity to capture carbon dioxides from gaseous and solid waste streams.
Source link: https://www.osti.gov/biblio/1854005
By its Dot/Icm type IV secretion system, Legionella pneumophila, an intracellular pathogen, converts more than 330 effectors into host cells. We found that the Dot/Icm substrate Ceg3 is a mono-ADP-ribosyl translocase that localizes to the mitochondria in host cells, where it targets ADP/ATP translocases by ADP-ribosylation and reduces ADP/ATP exchange activity by ADP-ribosylation. Our results show that modulation of host energy metabolism as a novel virulence mechanism for L. pneumophila.
Source link: https://www.osti.gov/biblio/1854915
Native gut flora has been shown to be a contributing factor in gut microbiome disease, as certain pathogens use -diglucosides to outcompete native gut flora. Potential prebiotics and alternative sweeteners for a variety of foods have been tested, including Kojibiose and n. . . . ose. Compared to the study of maltose metabolism, our understanding of the synthesis and degradation of rare -diglucosides is poor, and there are several key questions that remain unanswered, particularly in relation to the regulation of bacterial metabolism for -diglucosides.
Source link: https://www.osti.gov/biblio/1779713
Alternatively, biological mediators capable of customizing microbial metabolisms, in turn, open a new avenue for restoring physiological function. In this context, nanoparticle-based artificial mediators have been used to regulate cell metabolisms. Here, we reviewed recent developments toward the use of nano-based artificial mediators for the tuning of cellular metabolism, with a focus on electron transfer and pathway flux. Perspectives for future applications of artificial mediators for mediating microbial metabolisms were also provided.
Source link: https://www.osti.gov/biblio/1799515
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