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Metabolism - Crossref

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Last Updated: 15 May 2022

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Fuel metabolism in Canada geese: effects of glucagon on glucose kinetics

Glucagon has been shown to modulate avian energy metabolism during prolonged fasting, but the physiological effects of this hormone on long-distance migrant birds have never been investigated. We searched for signs of fuel mobilization via changes in metabolite concentrations using the Canada goose as a model species. Glucagon was found to lead to a 50 percent rise in glucose mobilization, and a 90 percent rise in plasma glucose levels was reported. This is the first to report how glucose kinetics of a long-distance migrant bird and determine its rates of glucose mobilization.

Source link: https://doi.org/10.1152/ajpregu.00080.2015


Diagnostic and Therapeutic Perspectives Associated to Cobalamin-Dependent Metabolism and Transcobalamins’ Synthesis in Solid Cancers

Ensuring these functions in cancer cells, therefore, necessitates significant cobalamin requirements and the transcobalamin II receptor. However, the connection between cobalamin and solid cancers is not limited to cellular metabolism, as it also involves circulating transcobalamins I and II carrier proteins, encoded by TCN1 and TCN2, respectively. B12, TCI, and TCII concentrations in plasma are linked to cancer onset and relapse, as well as the presence of metastases and worse prognosis.

Source link: https://doi.org/10.3390/nu14102058


Transcriptomic analysis of Stropharia rugosoannulata reveals carbohydrate metabolism and cold resistance mechanisms under low-temperature stress

Abstract Low temperature is a significant environmental factor that limits the expansion of Stropharia rugosoannulata; however, the molecular mechanisms that underpin S. rugosoannulata responses to low-temperature stress are largely unknown; Carohydrate enzyme genes were downregulated more in DQ-1 than DQ-3, according to a larger degree, and several cellulase activities were also reduced to a greater degree, according to more detailed study. In addition, the CAT1, GR, and POD genes, as well as other heat shock protein genes were upregulated in the two strains after low-temperature stress, and the GPX gene and additional heat shock protein genes were upregulated in DQ-3. Moreover, the expression of various types of antioxidant enzymes and heat shock proteins in S. rugosoannulata are also critical for the survival of low-temperature stress. In short, this report will provide the foundation for further investigation into key signaling pathways, gene expression, and variety breeding of S. rugosoannulata under low-temperature stress.

Source link: https://doi.org/10.1186/s13568-022-01400-2


Effects of Fat Type and Exogenous Bile Acids on Growth Performance, Nutrient Digestibility, Lipid Metabolism and Breast Muscle Fatty Acid Composition in Broiler Chickens

Totaling 4 treatments of six replicate pen with 18 chicks per replicate pen, a total of 432 one-day-old Arbor Acres male broilers were stochastically distributed to a 2 x 2 factorial layout made up of two fat types and two levels of BAs included in diets, comprising two fat types and two levels of BAs included in diets. On d 42, dietary intake of lard increased the digestibility of ether extract in diets and the percentage of breast muscle, as well as decreased serum triglycerides and serum aminotransferase activity on d 21 compared to treatments with soybean oil. When BAs were fed, serum total cholesterol content as well as the percentage of abdominal fat on d 42, and ALT usage on d 21 were reduced.

Source link: https://doi.org/10.3390/ani12101258


SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism

Abstract Background Cigarette smoking is a key risk factor for idiopathic pulmonary fibrosis. We previously reported that removing mitochondrial reactive oxygen species shields against CS-induced pulmonary fibrosis. Methods We treated cells with 1% cigarette smoke extract and measured mtROS by MitoSOX TM indicator. The effect of autophagy on lipid metabolism and LF activation was investigated. In vitro and in vivo, the effect of mitochondrial oxidative stress, autophagy flux, lipid metabolism, and LF activation were investigated. CS promoted mtROS production by increasing mtNOX4 production and lowering SOD2, according to the results. We found that CS promoted mtROS production by increasing mtNOX4 production and lowering SOD2. In vivo, we found that both SRT1720 and mitoquinone counteracted the effect of CS on NOX4, SOD2, PPAR, and CPT1a. Conclusions We demonstrated that CS reduced SIRT1 to stimulate LF by dysregulating lipid metabolism, owing to increased mtROS and decreased autophagy flux.

Source link: https://doi.org/10.1186/s12967-022-03408-5


A TetR family transcriptional regulator, SP_2854 can affect the butenyl-spinosyn biosynthesis by regulating glucose metabolism in Saccharopolyspora pogona

Results in S. pogona : SP_2854, a TetR family transcriptional regulator that can effectively control butenyl-spinosyn biosynthesis and influence strain growth, glucose intake, and mycelial morphology. To decipher the overproduction process in detail, comparative proteomic analysis was carried out in the SP-2854 overexpressing mutant and the original strain, and we discovered that SP_2854 overexpression increased the expression of proteins involved in glucose metabolism. Conclusion Our results show that SP_2854 can influence strain growth and development, as well as butenyl-spinosyn biosynthesis in S. pogona by regulating glucose metabolism.

Source link: https://doi.org/10.1186/s12934-022-01808-2


Poor hygiene of housing conditions influences energy metabolism in a muscle type-dependent manner in growing pigs differing in feed efficiency

Abstract The ability of pigs to cope with inflammatory conditions can be enhanced by plant selection for residual feed intake, a measure of feed quality. We reviewed skeletal muscle responses to degraded hygiene conditions in pigs who were mistakenly selected for RFI in the latest research. Pigs were housed in either poor or good sanitation conditions at 82 years of age, with low RFI and high RFI. Both RFI lines increased the protein content of microtubule-associated protein 1 light-chain 3 in both RFI units, suggesting an increase in the autophagy pathway.

Source link: https://doi.org/10.1038/s41598-022-12050-6


Detrimental effects of intrahospital transport on cerebral metabolism in patients suffering severe aneurysmal subarachnoid hemorrhage

OBJECTIVE The intrahospital transport of CT scans is now available for neurosurgical patients. During these procedures, intracranial hypertension and blood pressure changes that could impair cerebral perfusion are common, especially in the sedated and mechanically ventilated patient. This report reveals the effect of intrahospital patient transport on multimodality monitoring results, with a particular focus on cerebral metabolism. METHODS Forty intrahospital transports in 20 patients with acute aneurysmal hemorrhage under constant intracranial pressure, brain tissue oxygen saturation, and cerebral microdialysis monitoring were prospectively included. Multimodality neuromonitoring results during intrahospital transfer to the CT scanner and the subsequent ten hours were evaluated using linear mixed models. In 92 percent of patients, the ICP exceeded 20 mm Hg; pbtO 2 revealed a parallel increase from 23. 1 13. 3 mm Hg to 28. 5 23. 6 mm Hg due to an increase in the percentage of inspired oxygen during transport. Both ICP and pbtO 2 were returned to baseline values after. During the transport, Cerebral glycerol surged from 71. 0 54. 9 mol/L to 75. 3 56. 0 mol/L, which remained elevated for the next 9 hours. Patients with extended travel time were found to have elevated cerebral pyruvate and lactate, as well as lower glutamate levels in the post-transport period. Hence, intrahospital transport for neuroradiological imaging should be strongly reconsidered, and only confirmed if the intended benefit of imaging findings outweighs transportation risks.

Source link: https://doi.org/10.3171/2020.8.jns202280

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions