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Metabolism - ClinicalTrials.gov

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Last Updated: 15 June 2022

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Renal Metabolism of Glycolate to Oxalate

"The source of urinary oxalate is of concern, as calcium oxalate is a key component of kidney stones. " Primary hyperoxauria, the body's abnormality of primary hyperoxalate production, results in frequent kidney stones and kidney function loss, which may lead to kidney stone fractures. To get a realistic picture of how much oxalate is produced from normal glycolate breakdown in healthy human subjects, blood and urine samples will be tested for labeled glycolate and labeled oxalate.

Source link: https://clinicaltrials.gov/ct2/show/NCT04437225


Measurement of Energy Metabolism in Infants: BabyEE Pilot

"The overarching aim is to complete a prospective evaluation of energy expenditure in the newly infant metabolic chamber about a week before, to determine the accuracy and stability of infant protocols related to energy metabolism and physical fitness. " How can energy expenditure measurements in infants be adjusted to account for differences in infant size and body composition?

Source link: https://clinicaltrials.gov/ct2/show/NCT02683473


Fatty Acid MetabOlism in Individuals Undergoing Sulforaphane Supplementation (FAMOUS)

Participants will join the Oxford Center for Diabetes Endocrinology and Metabolism for a "postprandial study day" after an overnight fast. "Then on a separate day, within one week of being observed their liver and heart fat content, will measure for a 'postprandial research day. ' Participants will be encouraged to drink some 'heavy water' on the day before and during the'study day's course. A volunteer's 'heavy water' will have to consume is 3g heavy water per kg body water, which will result in a 0. 3% plasma water enrichment. Following the first blood samples obtained, the researchers will begin pumping fat labelled with special atoms into the other cannula. The researchers will obtain two adipose tissue biopsies three hours after consumption of the test breakfast meal. Participants will be encouraged to maintain their regular diets during the rehabilitation phase, which will be assessed by the completion of food diaries, which include all foods and beverages consumed on 3 days a week each week of the 3 week intervention phase. Following an overnight fast, participants's liver and heart fat content will again be measured using MRI/S at OCMR, and after a week of having their liver and heart fat content measured, they will join the CRU at OCDEM for a second'study day' after an overnight fast. The second'study day' will be similar to the first study day, as described above. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT04364360


Postprandial Fat Metabolism Following an Acute Exercise Bout in Persons With Spinal Cord Injuries

"Specifically, it is unclear to what extent exaggerated PPL in those with SCI-related failures in the use of exogenous and/or endogenous fats can be determined. " The aim of this research is to investigate the origins of exaggerated PPL in those with SCI and the consequences of an acute pre-meal exercise bout using novel stable isotope tracer techniques. Although muscle atrophy and diminished subcutaneous sympathetic activity following SCI may restrict fat use, preliminary results show that fat use rises during exercise in this population's postabsorptive state. The investigators also predict that reduced use of both fat sources" contributes to exaggerated PPL in SCI.

Source link: https://clinicaltrials.gov/ct2/show/NCT03691532


Family Studies in Metabolic Diseases and Mineral Metabolism

"Familial multiple endocrine neoplasia type 1, familial hypocalcemia, hyperparathyroidism, jaw tumor syndrome, other signs of familial isolated hyperparathyroidism, and pseudohypohyroidism are metabolic disorders that are largelyinherited in an autosomal dominant fashion. " In most FHH kindreds, the calcium-sensing receptor of the parathyroid cell is mutated; a minority of FHH kindreds have mutations of the GNA11 or AP2S1 gene. HPT-JT is a specific subtype of familial isolated hyperthyroidism with elements of parathyroid adenoma, parathyroid disease, jaw tumor, uterus tumor, kidney tumor, and kidney cysts. For the purpose of genetic analysis and gene identification, we are continuing to collect blood and tissue samples from impacted and unaffected members of kindreds with known or suspected MEN1, FHH, HPT-JT, FIHP, PHP, and other conditions.

Source link: https://clinicaltrials.gov/ct2/show/NCT00001345


Dynamic Post-Prandial Metabolism in Patients With Non-Alcoholic Fatty Liver Disease

"Non-alcoholic fatty liver disease is the most common hepatic disease in the Western world and is a leading cause of liver-related morbidity and mortality in the Western world. The complicated metabolic pathways linking nutrient intake and hepatic fat accumulation have yet to be fully understood. Excessive caloric intake and specific nutritional factors have been implicated in its pathogenesis, but the intricate metabolic pathways linking nutrient intake and hepatic fat accumulation have yet to be fully understood. By adopting a metabolomics-based dynamic paradigm, we suggest a pilot study to investigate patients with NAFLD's nutritional response to a standardized food challenge. In this study, we will recruit up to 50 patients with NAFLD and compare them to 12 controls with metabolic syndrome without NAFLD and 12 healthy controls. Following an overnight fast, participants will be placed in a metabolic chamber for continuous monitoring of metabolic levels, and will be served a liquid mixed meal containing approximately 30% of daily caloric intake for a period of 15 minutes. ".

Source link: https://clinicaltrials.gov/ct2/show/NCT02520609


Maternal Inborn Errors of Metabolism in Pregnancy: A Pregnancy Registry Protocol

"Women with inherited metabolic diseases are reaching child bearing age more often as a result of advances in early diagnosis and improved pediatric care. " The most evidence on pregnancy's effects of underlying inborn metabolism abnormality derives from the analysis of phenylketonuria. From the data gathered from many cases of PKU-associated pregnancy, key management issues were identified. For example, children born to mothers with unrestricted diet were significantly more likely to have intellectual impairment, microcephaly, and low birth weights than women who maintained a phenylalanine restricted diet. The excess phenylalanine may cause long-term health problems to the developing fetus, and now a vigilant metabolic approach is considered as standard in women with PKU desiring pregnancy. For example, nine published cases of methylmalonic academia in pregnancy and one case of cobalamin C deficiency in pregnancy have been reported in research journals, while research journals have reported the same cases. The paucity of publishing pregnancy in IEMs other than PKU may be due to a lack of systematic study to investigate pregnancy management in metabolic disorders. The purpose of this research was to establish a pregnancy registry of women with inborn errors of metabolism other than PKU. This report will also look at reproductive problems including infertility and the use of artificial reproductive technologies. Our registry information can also be used to disseminate management experience for all providers, acknowledging that individual centers do not have sufficient experience to make effective management decisions on their own.

Source link: https://clinicaltrials.gov/ct2/show/NCT02322177

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions