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Metabolism - Astrophysics Data System

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Last Updated: 15 May 2022

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Targeting iron metabolism using gallium nanoparticles to suppress ferroptosis and effectively mitigate acute kidney injury

We synthesized gallic acid-gall polyvinyl nanoparticles as a potential iron-scavenging agent due to their nearly ionic radius and chemical synchrony with iron. The findings revealed that GGP NPs were embedded in tubular epithelial cells and showed excellent biocompatibility, leading to high biocompatibility. An in vitro research found that treatment with GGP NPs significantly improved the renal tubular injury and mitochondrial damage caused by CP therapy or ischemia-reperfusion injury. According to our report, GGP NPs could be a safe and promising alternative for AKI treatment as well as facilitating future clinical translation.

Source link: https://ui.adsabs.harvard.edu/abs/2022NaRes.tmp..290X/abstract


A whole-body multi-scale mathematical model for dynamic simulation of the metabolism in man

We suggest a whole-body model of the metabolism in man as well as a generalized framework for modeling metabolic networks. We're able to create a large metabolic network in a organized and compact way by using this approach. In order to simulate metabolite concentrations during the feed-fast cycle, we use ingestion of food. Due to the addition of storage systems, the model can be depleted if food is not regularly eaten. In virtual clinical trials, a physiological model with intricate cellular metabolism and whole-body mass dynamics can be used.

Source link: https://ui.adsabs.harvard.edu/abs/2022arXiv220501473C/abstract


Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution

Inherently poor sensitivity, which limits the procedure for the majority of imaging water molecules in the body, hinders magnetic resonance imaging. Hyperpolarized molecules produce significantly enhanced MRI signals, opening the way for the study of low-concentration species in vivo. Cell necrosis in metabolic 13 C MRI is a biomarker of cell necrosis in metabolic 13 C MRI. We've come out of these setbacks in the production of PHIP-polarized [1-13 C]fumarate, a biomarker of cell necrosis in metabolic 13 C MRI.

Source link: https://ui.adsabs.harvard.edu/abs/2021PNAS..11825383K/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions