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Objection: To investigate the clinicoetiological profile of children with acute non-infectious encephalopathy (ANE) and determine the proportion of children with inborn metabolism inborn errors. Methods This descriptive cross sectional study was carried out in a tertiary care center in Northern India. Since ruling out CNS infection, chronic encephalopathy was discovered among the Consecutive children, aged more than 28 years and less than 12 years old, with acute encephalopathy. TMS/GCMS was used to determine IEM suspects, with subsequent mutation analysis for confirmation. Results In nine of these children, aged 3 to 42 years old, with female preponderance, fifty children with noninfectious encephalopathy were recruited and metabolic causes were found. IEM's key indicators of IEM were histories of the previously affecting siblings and consanguinity between the parents. IEMs were found to be the most common cause of NIE in the majority of cases. Conclusion IEMs account for a significant percentage of NIE in India, and a high degree of suspicion is required to make the diagnosis.
Source link: https://doi.org/10.1007/s12098-022-04087-2
Gynostemma pentaphyllum, a perennial liana herb of the Cucurbitaceae plant, has both nutraceutical and pharmacological uses. The aim of the current research was to investigate the preventative effects of G. pentaphyllum and Gypenoside-IV on metabolic problems in obese mice with gut microbiota dysbiosis. For ten weeks, G. pentaphyllum water extract and GP-IV were orally administered to DIO mice by gavage. Both GPWE and GP-IV inhibited obesity growth by reducing body weight gain, lowering fat mass/body weight ratio, and inhibiting adipocyte hypertrophy.
Source link: https://doi.org/10.1007/s11130-022-00982-3
The majority of Alzheimer disease patients have sporadic late onset AD, with dietary causes playing a significant role in AD's occurrence and development. In streptozotocin-injected and db mouse models of diabetes, we fed high-fat diet to pR5 mice expressing P301L mutant human tau, a rising trend in modern life, with the aim of creating a new model with characteristics of obesity, T2DM, and AD. We also investigated the effect of long-term HFD on tau pathology in WT and P301L mice's brains by performing western blotting of whole brain homogenates for total tau, phosphorylated tau at Ser396 and Thr231. Our findings show that pR5 mice fed with HFD are more susceptible to diet-induced obesity than to WT, particularly as the age rises. In both pR5 and WT mice, it was discovered that long-term HFD greatly elevates depression like behavior and impairs cognitive function, as well as induces anxiety-like behavior. Long-term HFD was also shown to exacerbate tau hyperphosphorylation in pR5 transgenic mice, and raise total and hyperphosphorylated tau in WT mice. In pR5 mice, HFD causes glucose intolerance and insulin resistance. pR5 mice are more susceptible to HFD-induced obesity than to WT, particularly as the age increases. PR5 mice are more susceptible to HFD-induced glucose intolerance impairment in comparison to WT, particularly with increasing age.
Source link: https://doi.org/10.1007/s11011-022-01029-x
Diabetes mellitus is a metabolic disorder that is characterized by the blood glucose level. Nutritional antioxidants play a major role in preserving the oxidative balance's homeostasis. Vitamin C, E, u03b2-carotenoids, polyphenols, and selenium have been evaluated as antioxidant constituents in the human diet diet. This paper emphasizes the role of antioxidants, which can help in lowering or maintaining the blood sugar levels in the body. Antioxidants are drugs that can help prevent cell damage caused by free radicals. In this paper, the investigation of a variety of antioxidants and their treatment in curing the disease is further explored.
Source link: https://doi.org/10.1007/s40200-022-01038-8
The gut microbiota of health and disease research has burgeoned curiosity in investigating the gut microbiota in health and disease, mainly due to rapid innovation in high-throughput multi-omics technologies. Integrated reviews of multi-omics studies, including metagenomics and metabolomics, as well as measurements of host response and cataloguing bacterial isolates, have found numerous bacteria and bacterial isolates that are closely related to disease. However, research into the mechanisms by which microbes affect intestinal health also needs to go beyond causation. The contribution of the gut microbiota to disease causality remains limited, largely due to the heterogeneity of microbial community epidemiology, interindividual variations in disease progression, and a lack of understanding of the mechanisms that link microbiota-derived signals into host signaling pathways. Several commonalities exist between inflammatory bowel disease and type 2 diabetes mellitus, two multifactorial diseases that have a trend of increasing global prevalence following industrialization. Changed in intestinal bacterial composition and variations in host processing of bacteria-derived metabolites are implicated in IBD and T2DM, and they provide a common pathogenetic pathway. Through gnotobiotic mouse experiments and integrative multi-omics studies, a causal link between dysbiotic microbial communities and IBD or T2DM has been established. Challenges in disease-specific biomarker discovery include investigating the causality of observed shifts, investigating their biological redundancy in disease mechanisms, and gut microbiota's geographic and ethnic heterogeneity. The development of type 2 diabetes mellitus and inflammatory bowel disease disease, as well as relapse risk and treatment response have been attributed to dysbiotic microbiome signatures.
Source link: https://doi.org/10.1038/s41575-022-00581-2
Patients with IEM who underwent CKRT in pediatric and neonatal intensive care units were analyzed. In patients with persistently high blood ammonia levels, blood ammonia levels > 250 u03bcmol/L, and blood leucine values, patients with persistently elevated blood ammonia levels & blood leucine levels were initiated into patients with persistently elevated blood ammonia levels, persistently high blood ammonia levels, and blood leucine levels ranging from 250 u03bcmol/L.
Source link: https://doi.org/10.1007/s00467-021-05329-9
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