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The bulb of Lilium brownii F. E. Brown is a common Chinese medicine to treat insomnia. Results after LB therapy, as well as the rise of pathological conditions in cells in the hypothalamus, were reversed. The abundant and diversity of intestinal flora and faecal metabolic phenotype changed by PCPA in rats were reversed after LB therapy, as well as increased 5-HT1A R and GABA A R, down-regulated level of NE as 8. 14 ng/mL, and the rise of pathological changes in the hypothalamus PCPA's effect on the arachidonic acid metabolism and tryptophan metabolism pathway was also tightly restricted by LB. Besides, it was also discovered that LB reduced the amounts of kynurenic acid related to psychiatric disorders and trimethylamine-N oxide associated with cardiovascular disease. Conclusion The underlying system of LB relieving insomnia involves regulating flora and metabolites to mimic the control group's.
Source link: https://europepmc.org/article/MED/34978949
Gynostemma pentaphyllum, a perennial liana herb of the Cucurbitaceae family, has both nutraceutical and pharmacological uses. The aim of this research was to investigate the preventative effects of G. pentaphyllum and Gypenoside-IV on metabolic signs in obese mice with gut microbiota dysbiosis. For ten weeks, G. pentaphyllum water extract and GP-IV were orally administered to DIO mice by gavage. We conclude that GPWE and GP-IV can possibly improve metabolic symptoms in DIO mice by altering gut microbiota.
Source link: https://europepmc.org/article/MED/35705767
The immunotoxicity of herbivorous insects exposed to heavy metals in herbivorous insects mimics those of herbivorous insects' susceptibility to entomopathogenetic agents. The susceptibility of gypsy moth larvae to Bacillus thuringiensis under Cd treatment at low and high doses was explored in this report, as well as the gut microbiome-hemolymph responses that affected larval disease susceptibility caused by Cd exposure. In larvae pre-exposed to Cd stress, mortality of gypsy moth larvae caused by B. thuringiensis was noticeably higher, as larvae pre-exposed to Cd stress, and there was a synergistic relationship between Cd pre-exposure and bacterial infection, according to our results. Because of gut microbiota dysbiosis and hemolymph metabolic disorder, obstructing gypsy moth larvae to B. thuringiensis in a synergistic way, and therefore microbial-based biological surveillance may be the most effective pest prevention technique in heavy metal-polluted areas.
Source link: https://europepmc.org/article/MED/35696962
According to epidemiological studies, food exposure to these antibiotic residues could be related to childhood obesity. In vivo, the effect of a residual dose of tylosin-an antibiotic growth promoter-on host metabolism and gut microbiota was investigated herein. The obesity-related phenotypes were transferrable to germfree recipient mice, implying that the effects of a TMDI dose of tylosin on obesity and insulin resistance were mainly due to changes in the gut microbiota. Tylosin TMDI in early life, the critical period of gut microbiota development, has increased the number of specific bacteria related to host metabolic homeostasis later in life. IMPORTANCE This study shows that, even with limited exposure in early life, a persistent dose of tylosin may cause long-term metabolic disruptions by altering the gut microbiota and its metabolites.
Source link: https://europepmc.org/article/MED/35670534
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