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Metabolic Syndrome - U.S. Department of Veterans Affairs

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Last Updated: 23 May 2022

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Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model.

Alzheimer's disease is often coexists with other aging-related illnesses, such as obesity, diabetes, hypertension, and cardiovascular diseases. MetS acceleration has been linked to the deletion of the Sirt3 gene. These results pointed to a new pathway that could connect SIRT3 deficiency to neuroinflammation, an important cause of Alzheimer's pathogenesis. We therefore hypothesized that MetS and amyloid pathology could interact in comorbid AD's converging pathways of insulin resistance and neuroinflammation. We crossed Sirt3-/- mice with APP/PS1 mice and successfully created APP/PS1/Sirt3-/- mice with amyloid pathology and MetS to investigate these interactions. During the cellular phase of AD, MetS may interact with amyloid pathology, according to our findings. Therapeutic therapy of SIRT3 in AD with comorbidities may have benevolent outcomes.

Source link: https://doi.org/10.1016/j.bbadis.2020.165849

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions