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Metabolic Syndrome - Springer Nature

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Last Updated: 23 April 2022

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Effects of glycine on metabolic syndrome components: a review

Purpose Glycine is the simplest and most common amino acid in humans. Here, we reviewed the most recent evidence confirming the role of glycine in the creation and treatment of metabolic syndrome components. Conclusions In vivo, the amount of glycine synthesized in vivo is insufficient to satisfy metabolic needs in these species, according to available reports. In subjects with metabolic syndrome, plasma glycine levels are lower than those in healthy individuals. Patients with metabolic syndrome may have a major medical effect on the treatment of diabetic patients with metabolic syndrome in the future.

Source link: https://doi.org/10.1007/s40618-021-01720-3


Differential prognostic value of resistin for cardiac death in patients with coronary artery disease according to the presence of metabolic syndrome

Reports concerning the prognostic value of resistin in stable coronary artery disease patients are mixed. We prospectively investigated the long-term prognostic value of resistin in patients with stable CAD. [HR 1. 044; 95% CI 0. 994–1. 068; p = 0. 087] neither secondary endpoints [core 0. 986; 0. 973–1. 068] nor secondary endpoints [HD 1. 025; 0. 983–1. 068] nor are there any predicted cardiac deaths [HR 1. 044; 0. 994–1. 096; p = 0. 087] neither primary endpoints [HR 1. 055; 0. 983–1. 068] nor the 0. 983; 0. 983; 0. 995; 0. 983; 0. 983; 0. 993; 0. 989; 0. 996; 0. 983; 0. 994; 0. 984; 0. 983; 0. 983; 0. 973; 0. 968; 0. 6; 0. 8; 1. 068; 1. 068; 0. 980; 1. 068; 0. 983; 0. 966; 1. 068; 0. 983; 0. 6; 0. 979; 1. 068; 0. 980; 1. 068; 0. 980; 1. 068; 0. 973; 0. 6; 0. 983; 0. 981; 1. 0 After adjusting for conventional risk factors [HR 1. 121; 0. 9 percent CI 1. 045–1. 204], p = 0. 002. Patients with resistin values 7. 6 ng/mL median level were at 2. 8 times higher risk of cardiac death than those with faulty risk factors and LVEF HR 2. 882; 95% CI 1. 311–6. 336; p = 0. 008. Resistin is merely associated with cardiac death in patients with stable CAD and MS.

Source link: https://doi.org/10.1007/s00380-021-01964-2


Investigation of ^1H nuclear magnetic resonance relaxometry to screen metabolic syndrome and diabetes

NMR relaxation time in human serum correlated well with several biomarkers associated with diabetes and metabolic syndrome, according to the study. NMR relaxation times between subjects with normal and poor metabolic health were observed in statistically significant differences.

Source link: https://doi.org/10.1007/s44211-022-00113-7


An exploration of new methods for metabolic syndrome examination by infrared thermography and knowledge mining

Metabolic syndrome is a medical condition characterized by multiple metabolic disorders. This research sought to investigate the differences between healthy people and MS patients using infrared thermography as the diagnostic criteria for MS remain unclear. Each participant's IRT image was divided into the region of concern by the preprocessing technique used in this study, and then the ROI analysis was granulated by the K-means algorithm to create the formal background, and finally, the two formal background was turned into a knowledge graph using the attribute partial order model. The IRT image can be divided into 18 ROI with the image processing method. The difference between the chest and face of the two groups' average temperature and maximum temperature difference between the two groups' samples and independent-samples T test can be discovered by knowledge mining and independent-samples T test, which can be statistically different Prefers.

Source link: https://doi.org/10.1038/s41598-022-10422-6


Lifestyle as well as metabolic syndrome and non-alcoholic fatty liver disease: an umbrella review of evidence from observational studies and randomized controlled trials

An umbrella review of meta-analyses was carried out to summarize the quality of evidence relating to lifestyle, metabolic syndrome, and non-alcoholic fatty liver disease in terms of risk and prevention. Meta-analyses of observational studies and randomized controlled trials looking at the effects of lifestyle and metabolic syndrome with NAFLD risk or treatment were among the targets. In meta-analyses of observational studies, quality of evidence was rated high only for the relationship of sugar-sweetened soda intake with elevated NAFLD risk. Conclusions Despite several meta-analyses comparing lifestyle and metabolic syndrome with the risk or treatment of NAFLD, an extensive clinical RCT is required to investigate the connections between lifestyle changes and disease progression.

Source link: https://doi.org/10.1186/s12902-022-01015-5


Evaluating machine learning-powered classification algorithms which utilize variants in the GCKR gene to predict metabolic syndrome: Tehran Cardio-metabolic Genetics Study

Background Physiological syndrome is a common multifactorial disorder that can raise the risk of diabetes, cardiovascular disease, and cancer. We wanted to test different machine learning classification methods in predicting metabolic syndrome severity and determining risk factors besides identifying common genetic or environmental risk factors. Methods This candidate gene analysis was conducted on 4756 eligible participants from the Tehran Cardio-metabolic Genetic Research Institute. MetS is a 4% risk for people with BMI 24 and physical activity 8. In comparison, a person with a BMI 25, physical fitness 2. 7, and age 33. Conclusion The results showed that machine learning algorithms outperformed conventional statistical methods for patient classification, on average. These well-performing models can be used to design future support services that use a variety of data sources to identify people at risk of getting MetS.

Source link: https://doi.org/10.1186/s12967-022-03349-z


Adolescence exposure to China’s great famine period and the association of metabolic syndrome in adulthood: a retrospective study

Background Exposure to famine early life is linked to several health problems in adulthood, but the effect of famine exposure during adolescence is uncertain. This study intends to determine if famine in adolescence is related to metabolic syndrome in adulthood. Methods This report included 4130 Chinese adults aged 59-71 from the 2011 China Health and Retirement Longitudinal Study. Participants who were exposed to famine during adolescence were more likely to experience MetS during adolescence than those who were not. The non-adolescent group was less likely to report MetS. The effects of famine exposure during adolescence on MetS were not apparent among males only after stratification by sex. In addition, males with a history of drinking were more likely to experience Mets than those without. Those elderly people who suffered famine during adolescence may help avoid MetS formation in later life.

Source link: https://doi.org/10.1186/s12889-022-13047-6


Transethnic meta-analysis of exome-wide variants identifies new loci associated with male-specific metabolic syndrome

Background Metabolic syndrome is a group of very common health disorders that have contributed to a better understanding of rare variants, which go beyond exome-wide association studies to possibly identify causative variants among ethnic groups. Methods We analyzed genotype results of 5302 European subjects in the discovery stage of the European METabolic Syndrome In Men study, which was derived from exome chips and 2481 subjects, in the replication phase, among 6 independent cohorts of 5 ancestries using whole-exome sequencing. MetS is a lipid transfer protein that is linked to the cholesteryl ester transfer protein, according to a gene-based alliance.

Source link: https://doi.org/10.1007/s13258-021-01214-9


Prediction of metabolic and pre-metabolic syndromes using machine learning models with anthropometric, lifestyle, and biochemical factors from a middle-aged population in Korea

Background: Metabolic syndrome is a multi-system disorder that appears as a series of metabolic abnormalities and is closely linked to the prevalence of a variety of illnesses. Early detection of MetS in the middle-aged population provides greater benefits for cardiovascular disease-related health outcomes. This research sought to find the most appropriate MetS prediction model for the middle-aged Korean population using the latest machine learning methods. Methods We extracted 20 data types from the Korean Medicine Daejeon Citizen Cohort, a cohort study of a community-based cohort of adults aged 30 to 55 years old, based on a population-based population of adults aged 30 to 55 years old. The area under the receiver operating characteristic curve increased by up to 0. 091 when the SMOTE was introduced, with XGBoost showing the highest AUC of 0. 851. Conclusions Tree-based machine learning algorithms were highly effective in identifying MetS with high accuracy in middle-aged Koreans.

Source link: https://doi.org/10.1186/s12889-022-13131-x


Prognostic significance of three endothelial nitric oxide synthase (eNOS) polymorphisms and metabolic syndrome (MetS) in patients with colorectal cancer

However, the effect of eNOS polymorphisms and metabolic syndrome on colorectal cancer prognosis remains unclear, though. Methods We genotyped three polymorphisms of eNOS in 312 CRC cases from the Korean population by polymerase chain reaction fragment length polymorphism analysis. Result Conclusions Although the three eNOS polymorphisms were not related to MetS, the 894G > T polymorphism's TT genotype in the CRC group with MetS was correlated with a lower survival rate in the CRC group without MetS compared to the GG genotype in the CRC group without MetS. Conclusions The eNOS polymorphisms in CRC patients were not correlated with metabolic syndrome prevalence.

Source link: https://doi.org/10.1007/s13258-022-01246-9

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions