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For the Mediterranean diet, the modulatory effect of diet on the metabolic syndrome phenotype has been demonstrated, and nuts are the primary determinants of these health benefits. This review of the effect of nuts on the risk factors of metabolic syndrome among the metabolic syndrome cluster examined studies—prioritizing meta-analyses and systemic reviews—to state the potential benefits of nut ingestion on the risk of metabolic syndrome associated with menopause.
Source link: https://doi.org/10.3390/nu14081677
Because of its anti-inflammatory and antioxidant properties, Pomegranate can be used as a multipurpose medicinal and dietary supplement. Pomegranate can be used to prevent or treat metabolic syndrome risk factors. Although earlier published studies on the effects of pomegranate on various diseases, there is no systematic review of any MetS-related risk factors that solely focuses on clinical trials related to all MetS-related risk factors. The aim of this up-to-date, comprehensive, and systematic review is to critically assess pomegranate's risk factors on a variety of MetS risk factors based on scientific findings. According to the Cochrane Handbook on Systemic Reviews of Interventions, the Preferred Reporting Items for a Systematic Review and Meta-Analysis recommendations were used, and the bias risk analysis was carried out. According to the included studies, pomegranate can reduce body weight, blood pressure, glycemia, triglycerides, total cholesterol, and low-density lipoprotein cholesterol.
Source link: https://doi.org/10.3390/nu14081665
Metabolic syndrome is linked to a variety of chronic illnesses for which lifestyle changes are often considered the bedrocket of treatment. While this measure may raise insulin sensitivity and other health indicators, other health indicators can be useful, weight loss alone is not always effective in addressing all risk factors associated with MS. Diet quality has been found as a significant factor in lowering the risk of MS without weight loss, according to previous studies. It is well established that dietary assessment devices capable of determining dietary patterns that increase the risk of MS are indispensable to the creation of personalized, targeted diet and lifestyle recommendations. This paper examines current dietary and eating habits associated with MS development, which the AHA's recommendation. This paper provides a summary of recent dietary assessment software that can be used by the AHA to determine dietary and eating habits associated with MS development.
Source link: https://doi.org/10.3390/nu14081557
We hypothesized that inclusion of potatoes in a Dietary Guidelines for Americans can improve cardiometabolic and gut health in metabolic syndrome individuals, consistent with potatoes being high in micronutrients and resistant starch. Before beginning oral glucose and intestinal permeability tests, MetS participants consumed a DGA-based diet for two weeks without including potatoes or bagels in a randomized cross-over trial. Hence, short-term intake of a DGA-based diet reduces cardiovascular risk, and the incorporation of resistant starch-containing potatoes into a healthy diet reduces small intestinal permeability and postprandial endotoxemia.
Source link: https://doi.org/10.3390/nu14081545
Metabolic syndrome is common in Taiwan, but the relationship between MetS and cognitive function is unclear. In a large Taiwanese population, the aim of this research was to investigate the relationships between MetS, its components, and obesity-related indices with cognitive function. We had a total of 28,486 people who completed the Mini-Mental State Examination questionnaire, which was used to measure cognitive performance. While cognitive impairment worsened, MetS and its components' prevalence increased, as did the number of MetS components and the number of MetS components increased. In addition, rises in all obesity-related index values were correlated to a decrease in cognitive function. MetS, abdominal fat, low serum cholesterol, low high-density lipoprotein cholesterol, and hyperglycemia were all significantly related to a poor MMSE ranking, according to a multivariable model. Our findings reveal that MetS and its components may cause cognitive decline, as well as elevated prevalence of obesity-related indices, which were associated with poor cognitive function.
Source link: https://doi.org/10.3390/nu14081535
We investigated the early effects of MS on the K ATP channels' conductance, ATP, and glybenclamide sensitivity. For 8 weeks as a MS model, We used Wistar rats fed with a high-sucrose diet. Pancreatic beta cells in their K ATP channels were similar in excised membrane patches, measurement, and HSD channels. This research shows that early effects of MS made by eating high-sugar beverages can influence K ATP channels, one of the diabetes treatment drugs.
Source link: https://doi.org/10.3390/metabo12040365
Transient receptor potential channels are non-selective calcium channels involved in a slew of physiological conditions, including energy balance, inflammation, and oxidative stress, among others. Evidence from animal models of disease has helped to identify their particular contributions to MS, which may help to design medical trials for the condition. In the midst of new therapies to manage this condition, the interplay between these TRP channels and oxidative stress in MS is explored here.
Source link: https://doi.org/10.3390/cells11081292
MeS is also associated with persistent kidney disease. This research was done to determine kidney fructose metabolism and whether fructose treatment alone results in intrarenal fat accumulation. Rats in the Sprague Dawley family were either a regular chow or a high-fructose diet, according to either normal chow or a high-fructose diet. For 48 hours, HK2 cells were treated with fructose for 48 h, and ChREBP and DNL gene expression were determined. The HFrD rats had elevated blood pressure, glucose, and triglyceride values, according to the HFrD rats. The HFrD rats' kidney mass was noticeably higher than Ctrl rats, and Ctrl rats' blood pressure was also elevated. The lipid droplet formation in the HFrD kidneys was also aided by elevated adipophilin mRNA expression, according to oil red staining. In the HFrD kidneys, mRNA expression in ChREBP and its downstream genes, scd and fasn, was elevated. ChREBP in treating HK2 cells with 40 mM fructose increased the expression of ChREBP.
Source link: https://doi.org/10.3390/biology11040618
Metabolic syndrome is a disease with a complex etiology. MetS is now a significant issue in the public health care system. Polyphenols have been shown to be a "possible cure," owing to their antioxidative and anti-inflammatory activity as well as their ability of normalizing carbohydrate and lipid metabolism, according to many of them. Polyphenols may play a role in preventing or delaying MetS or related problems. In addition, the intake of polyphenol-rich foods should be considered a substitute for antidiabetic medications. Researchers have used laboratory animals to demonstrate pathophysiological changes specific to MetS to ensure the accuracy of the results, control, and potential human health benefits. Based on in vivo animal models, the present paper presents an overview of animal studies of MetS, promising polyphenolic compounds with their bioactive capability, effect on metabolic pathways, and supplementation-related benefits.
Source link: https://doi.org/10.3390/biology11040559
We hypothesized the interaction of this compound with gut microbiota as the primary cause for metabolic abnormalities since geraniin has poor bioavailability. Male Sprague Dawley rats were divided into normal diet - and HFD-fed animals and treated with geraniin and an enriched extract of geraniin. We found that 5 mg geraniin and 115 mg GEE supplementation significantly reduced glucose intolerance, lipopolysaccharide-binding protein, total cholesterol, triacylglyceride, and low-density lipoprotein; elevated insulin sensitivity; and significant rises adiponectin and hepatic PPAR expressions.
Source link: https://doi.org/10.3390/antiox11040632
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