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Background: Objective: To find out whether obesity with or without metabolic syndrome is prospectively correlated with coronary artery calcium deposition and event cardiovascular disease events. In our main study, metabolic syndrome was defined as body mass index 30 kg/m 2 without any metabolic syndrome components. Subject to the MHO's definition, MHO volunteers had a significant risk of CAC progression in comparison to their physically fit normal weight peers. Any of the metabolically unhealthy status metrics, Obesity with a poor metabolic profile remained the highest risk of CAC progression and cardiovascular disease events. MHO participants who went from year 15 to year 20 or year 25, approximately 60% of participants exhibited metabolically obese obesity from year 15 to year 20 or year 25. Conclusions: Different metabolic phenotypes of obesity begin at a young age have different risks of CAC formation and subsequent cardiovascular disease events in later midlife.
Source link: https://doi.org/10.1161/atvbaha.122.317526
Methods The PubMed, Embase, and Cochrane Library databases were searched from their inception to 7 March 2021 to find the prospective cohort studies investigating stroke risk among different metabolic syndrome/obesity phenotypes. The risk of stroke only increased when the MHO participants were predominantly females from North America, and when the World Health Organization standard was used to define obesity, which was not clear. A longer follow-up duration was also associated with a higher risk of stroke in the subgroup's review of stroke risk in MHOW. Regardless of the body mass index, the risk of stroke for all metabolically impaired phenotypes rises. High BMI contributes to stroke risk in metabolic health, but elevated BMI indicates significant heterogeneity, requiring future study into the effect of sex and transition of the metabolic status on stroke risk.
Source link: https://doi.org/10.3389/fcvm.2022.844550
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