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Indolepropionic acid, which is derived from diet tryptophan via gut microbiota conversion, is negatively associated with type 2 diabetes mellitus and systemic low-grade inflammation, according to previous studies. In the current study, obesity results in a dramatic decrease in IPA levels in both the serum and colonic mucosa, as well as glucose and lipid metabolism disorders. Both in vivo and ex vivo, IPA promoted the expansion of the tuft cell lineage in the gut and raised the mystery of interleukin 25, which contributes to the integrity of the gut barrier. Overall, our findings show that IPA supplementation prevents the onset of high-fat diet-related obesity and metabolic disorders by restoring tuft cell function, which may also be a potential agent for obesity treatment.
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