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Metabolic Obesity - U.S. Department of Veterans Affairs

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Last Updated: 08 June 2022

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Subcutaneous Adipose Tissue Metabolic Function and Insulin Sensitivity in People With Obesity.

"We found that elevated insulin-stimulated whole-body glucose uptake in insulin-sensitive diabetics with obesity was not due to glucose channeling into SAT, but rather, due to increased insulin-stimulated muscle glucose uptake. " In addition, we found no differences in adipocyte size, SAT perfusion, and oxygenation, as well as indicators of SAT inflammation among insulin-resistant and insulin-sensitive obese patients. Even though SAT was ineffective to the inhibitory effect of insulin on lipolysis in the insulin-resistant obese population, plasma fatty acid level was not different between insulin-sensitive and insulin-resistant obese participants. These results show that several putative SAT factors commonly blamed for insulin resistance are likely causes of insulin resistance in addition to insulin resistance, which are unrelated to insulin sensitivity.

Source link: https://doi.org/10.2337/db21-0160

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions