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Metabolic Obesity - Europe PMC

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Last Updated: 08 May 2022

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S1P/S1PR3 signalling axis protects against obesity-induced metabolic dysfunction.

S1PR3 gene expression in obese C57BL/6 J mice's adipose tissues and liver was elevated in comparison to those who were not nourished by low fat diet-fed peers. Weight gain was similar in both S1PR3-/- mice and WT littermates on a HFD; however, HFD-fed S1PR3-/- mice had a phenotype of partial lipodystrophy, exacerbated insulin resistance, and glucose intolerance, suggesting HFD-fed S1PR3-/- mice. In 3T3-L1 preadipocytes S1P increased adipogenesis, but S1P-S1PR3 signalling regulated the expression of PPAR, suggesting a new place for this signalling pathway in the adipogenic program.

Source link: https://europepmc.org/article/MED/35094654


Indolepropionic Acid reduces obesity-induced metabolic dysfunction through colonic barrier restoration mediated via tuft cell-derived IL-25.

In the current research, obesity leads to a dramatic decrease in IPA levels in both the serum and colonic mucosa, as well as in glucose and lipid metabolism disorders. IPA therapy had no effect on adipocyte differentiation in adipose tissue, but it did appear to have reduced adipose inflammation, effectively preventing adipocyte enlargement, which prevented adipocyte enlargement. Both in vivo and ex vivo, IPA greatly promoted the expansion of the tuft cell lineage in the gut and increased the mystery of interleukin. Our findings show that IPA supplementation helps prevents the development of high-fat diet-induced obesity and metabolic disorders by improving tuft cell-IL-25-mediated colonic barrier integrity, resulting in obesity prevention and metabolic disorders; thus, IPA may be a potential treatment for obesity treatment.

Source link: https://europepmc.org/article/MED/35509122


Effect of Momordica charantia Administration on Anthropometric Measures and Metabolic Profile in Patients with Obesity: A Pilot Clinical Trial.

The aim of this report was to determine the effect of the Momordica charantia administration's anthropometric measurements in obese patients. Twelve patients were randomly administered MC for 12 weeks, and 12 patients were treated with placebo. Although BW, BMI, WC, and body fat percentage reductions were found in the MC group, no such measurements could be used to determine statistical significance. In comparison, a placebo group saw significant rises in BW and BMI. After the MC administration, no significant changes in BW, BMI, WC, and body fat percentage were recorded; however, MC significantly reduced TG and VLDL levels, which was disappointing in conclusion.

Source link: https://europepmc.org/article/MED/35507955


Dietary fiber combinations to mitigate the metabolic, microbial, and cognitive imbalances resulting from diet-induced obesity in rats.

For eight weeks, diet-induced obese rats were fed oligofructose alone or in combination with -glucan, impeded starch, or a non-responsive starch. Only the HFS/O group showed a decrease in body weight and body fat, but all fiber interventions improved insulin sensitivity and cognitive function. The HFS/O diet was the least beneficial at improving cognitive function, but only the HFS/OB group reported rises in glucose tolerance, underlining the various effects of fiber types. Beneficial Bifidobacterium and Lactobacillus abundances in both fiber groups increased, according to Bifidobacterium and Lactobacillus abundance, while the HFS group had a higher concentration of Clostridium. Fecal microbiota transplantation from fiber-treated rats to germ-free mice did not alter body composition in the mice, but it did result in a larger number of Bacteroides in the HFS/O and HFS/OB groups relative to HFS.

Source link: https://europepmc.org/article/MED/35344215


Effect of severe compared with moderate energy restriction on physical activity among postmenopausal female adults with obesity: a prespecified secondary analysis of the Type of Energy Manipulation for Promoting optimum metabolic health and body composition in Obesity (TEMPO) Diet randomized controlled Trial.

Objectives We wanted to see the effects of weight loss by severe as opposed to moderate energy restriction on physical fitness over the past 36 months. Methods: A total of 101 postmenopausal female adults were randomly assigned to 12 mo of moderate energy restriction with a food-based diet, or a serious intervention involving 4 mo of severe energy restriction, followed by 8 mo of moderate energy restriction. Conclusions The severe group compared to the moderate group had the following characteristics: total number of physical fitness; duration of moderate-to-intensity physical fitness; duration of light-intensity physical activity; and shorter mean duration of sedentary time; Compared to the moderate group. ACTRN12612020651886 was the first trial published in www. anzctr. org. au as ACTRN12612000651886.

Source link: https://europepmc.org/article/MED/35102380


Failure of subcutaneous lipectomy to combat metabolic dysregulations in ovariectomy-induced obesity in young female rats.

Purpose The deleterious effect of visceral adipose tissue accumulation is well documented. The aim of this research is to investigate the hormonal consequences of subcutaneous abdominal adipose tissue lipectomy in ovariectomized obese rats, as well as the role of adipokines in these changes. Methods The research was conducted on young female rats and then divided into two main groups based on the length of the study, namely, 5-week and 10-week. Body mass index measurement and body mass index determination were performed on rats during body mass index testing. Estimated blood glucose, lipid profile, liver function, plasma malondialdehyde, leptin, and adiponectin were calculated, as well as the amounts of both blood and hepatic tissue of reduced glutathione were determined. Obesity caused by autophagectomy is a significant rise in BW and BMI. Conclusion Despite the immediate success of subcutaneous lipectomy for weight loss and/or body shaping, several delayed risks follow the procedure, which should be carefully considered.

Source link: https://europepmc.org/article/MED/35486321


Metabolic factors in the regulation of hypothalamic innate immune responses in obesity.

There is growing evidence that innate immune stimulation in the mediobasal hypothalamus is a key factor in diet-induced obesity's pathogenesis. Microglia, the resident immune cells in the brain parenchyma's organ parenchyma's brain parenchyma, has been shown to play roles in a variety of aspects of brain function, including circuit refinement and synaptic pruning. Microglia have also been implicated in the formation and progression of neurological disorders as a result. Here, we review the current findings into how these peripheral signals influence the innate immune response in the MBH and allow microglia to regulate metabolic regulation.

Source link: https://europepmc.org/article/MED/35474339


Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.

Obesity is also a economic and social burden in developed countries. Blocking of the production of inositol pyrophosphate kinase has been identified as a potential therapeutic treatment for obesity and related disorders. 20 reduced inositol phosphate levels by 66-81%, according to HCT116 colon cancer cell line's phosphate profiling, but not significantly differentiating levels of other inositol phosphates. In sum, inhibitor 20 can be used as an in vivo probe for IP6K-related studies.

Source link: https://europepmc.org/article/MED/35467861


Obesity and breast cancer risk: the oncogenic implications of metabolic dysregulation.

Context Breast cancer is on the rise in incidence in parallel with rising rates of obesity around the world. Evidence synthesis Elevated body mass index and weight gain are both associated with an elevated risk of postmenopausal, hormone receptor-positive breast cancer. Evidence shows that inadequate body composition screening in people of any weight can also raise breast cancer risk. Breast cancer risk reduction can be attributed to decreased breast cancer risk, and more specifically, fat loss through lifestyle and pharmacologic interventions. Incorporating indicators of metabolic health and body composition measurements with body mass index measurements can help identify breast cancer risk more accurately. To reduce the prevalence of obesity-related cancer, further research into body fat levels is needed.

Source link: https://europepmc.org/article/MED/35453151


Association of cholesterol and oxysterols in adipose tissue with obesity and metabolic syndrome traits.

A significant amount of body cholesterol is present in humans in Objective Adipose tissue. Adipose tissue deficionation may be one of the metabolic syndrome's contributing factors during weight gain. Methods The FAT expandability study found concentrations of cholesterol and oxysterols in 19 adult women with body mass index between 23 and 40 kg/m2 in subcutaneous and visceral adipose tissue, according to HPLC-MS/MS. Insulin was directly related to 24S-hydroxycholesterol in both adipose tissue and 27-hydroxycholesterol in visceral tissue. In both adipose tissues and 24S-hydroxycholesterol in visceral tissue, cholesterol levels with 24S-hydroxycholesterol were higher than with 27-hydroxycholesterol, where cholesterol correlation with 24S-hydroxycholesterol was higher than with 27-hydroxycholesterol. In visceral adipose tissue, the tissue cholesterol content correlated more with 27-hydroxycholesterol in subcutaneous adipose tissue than with 24S-hydroxycholesterol. While adipose 24S-hydroxycholesterol levels appear to be correlated with some metabolic syndrome signs and inflammation, and inflammation, adipose 27-hydroxycholesterol may provide some protection against them.

Source link: https://europepmc.org/article/MED/35453148

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions