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Metabolic Disorders - Europe PMC

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Last Updated: 23 April 2022

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Clinical diagnosis of metabolic disorders using untargeted metabolomic profiling and disease-specific networks learned from profiling data.

Untargeted metabolomics is a universal molecular profiling technique that can be used to search for metabolic abnormalities inborn. We used CTD, an automated diagnostic program that "connects the dots" between metabolite variations detected in individual metabolomics profiling results and modules identified in disease-specific metabolomics profiling networks learned from previous profiling results. To provide additional network-quantified predictors for use in diagnosis, we also extended CTD to determine distances between any two individuals and between an individual and a disease state. CTD, CTDdm, and CTDncd's CTD, CTDdm, and CTDncd's CTDdm's CTDdm and CTDncd's ability can help with the analysis of untargeted metabolomics results that can help diagnosticians assist diagnosticians in clinical decision-making. CTD can increase the speed and stability by which clinical laboratory directors make diagnostic and treatment decisions by automating and quantifying the interpretation of perturbation patterns, as well as automatically improving performance with new case data.

Source link: https://europepmc.org/article/MED/35449147


Integrated gut microbiome and metabolome analyses reveals an inconsistent dose effect of a tuna oil with more higher docosahexaenoic acid content on intestinal dysbiosis and metabolic disorders in high-fat diet-fed mice.

Background information about tuna oil, which is different from fish oil and high docosahexaenoic acid content, have drew significant scientific interest in recent years. A prepared tuna oil with more DHA content was used in this study. In diet-induced obese mice, it was the first to examine the effect of HDTO on gut dysbiosis and metabolic disorders. HDTO was helpful in reversing the high-fat-diet-induced metabolic disease and modifying the gut microbiota composition and function, but these effects were not consistent or dose-dependent. Conclusion Several doses of HDTO may attenuate endogenous disorders to different degrees by governing many distorted pathways to the normal state. This concise dose analysis for novel fish oil with high-DHA will serve as a helpful reference for those looking to tap its clinical therapeutic value.

Source link: https://europepmc.org/article/MED/35368101


Non-conventional therapeutical approaches to acne vulgaris related to its association with metabolic disorders.

The ever-increasing frequency of metabolic syndrome is still a significant problem for the public health care system around the world. Many skin disorders, including acne vulgaris, are linked to metabolic disorders, including acne vulgaris, thanks to the pro-inflammatory pathways and insulin resistance that are elevated in metabolic syndrome. A comprehensive investigation of MetS and acne vulgaris may aid in the design of new treatment plans.

Source link: https://europepmc.org/article/MED/35378101


Programming of future generations during breastfeeding: The intricate relation between metabolic and neurodevelopment disorders.

Although breastfeeding is known to avoid several diseases in the infant, changes in milk composition have been correlated with changes in central nervous system maturation and differentiation. Changes in milk quality and quantity may lead to metabolic dysfunction later in life, but neuronal disease has also been attributed to the onset of neuronal disorders. This review examines the interconnected risks that maternal metabolic status/unbalanced diets change during lactation and offspring's development of metabolic and neurodevelopmental disorders.

Source link: https://europepmc.org/article/MED/35367466


Metabolic Disturbances, Hemoglobin A1c, and Social Cognition Impairment in Schizophrenia Spectrum Disorders

In this analysis, metabolic measurements and social cognition were assessed in 245 participants with SSD and 165 healthy comparison subjects, excluding those with hemoglobin A1c > 6. 5%. During a naturalistic social task, functional connectivity within and between social media networks was measured. Among SSDs, a significant inverse correlation was discovered between socioeconomic awareness and cumulative metabolic disease, as well as HA1c. The relationship between socio cognition and HA1c was strong across domains and measures of social cognition, including age, sex, race, non-social neurocognition, hospitalization, and treatment with different antipsychotic drugs. SSD participants were more adversely affected by elevated HA1c as a result of a group x HA1c syndrome, according to a group x HA1c result, indicating that SSD participants were more affected by increasing HA1c. We also have the first study demonstrating a strong correlation between social awareness and elevated glucose metabolism in SSD.

Source link: https://europepmc.org/article/PPR/PPR476766


Effect of Dietary Exposure to Acrylamide on Diabetes-Associated Cognitive Dysfunction from the Perspectives of Oxidative Damage, Neuroinflammation, and Metabolic Disorders.

Acrylamide is a volatile chemical that is widely used in food processing, but it is unclear if daily dietary intake of acrylamide can exacerbate diabetic diabetics' cognitive impairments and the potential driving mechanisms. The aim of the current research was to investigate the effects of persistent acrylamide exposure on cognitive and memory function, as well as brain inflammation, neuroinflammation, and brain metabolic disturbance. Goto-Kakizaki rats, a diabetic rodent model of diabetes, were orally administered acrylamide at 1 mg/kg body weight for eight weeks. In GK rats, the results of the novel object recognition and Y-maze tests showed that acrylamide use significantly exacerbated diabetes-associated cognitive dysfunction. This work illustrates the effect of acrylamide consumption in the daily diet on diabetes-related cognitive dysfunction and its underlying mechanisms.

Source link: https://europepmc.org/article/MED/35364817


The potential protective effect of the Polygonum hydropiper L against the development of fructose-induced oxidative stress and metabolic disorders in male Sprague-Dawely rats.

In fructose-induced hypertensive rats, this research was intended to investigate the effects of a neous methanol extract of P. hydropiper on oxidative stress and metabolic changes. By aninvasive technique, blood pressure [systolic, diastolic, mean arterial pressure and heart rate were measured] as well as reactivity of extracts with phenylephrine and adrenaline were determined. Key results Aqueous methanolic extract of P. hydropiper at 400 mg/kg elevated the blood pressure, heart rate, body weight, and caused significant effects on metabolic and oxidative stress changes relative to fructose-fed groups. Conclusion According to polyphenols and flavonoids, aqueous methanolic extract of P. hydropiper has an effect on oxidative stress and metabolic changes as a result of polyphenols and flavonoids.

Source link: https://europepmc.org/article/MED/34165561


Specific metabolic syndrome components predict cognition and social functioning in people with type 2 diabetes mellitus and severe mental disorders.

People with type 2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia are more common in people with objective Obesity and metabolic diseases such as metabolic syndrome. Conclusions Cognitive impairment in the MetS group was considerably higher than in the No-MetS group than in the No-MetS group, with limited effect sizes. With TG and FPG, the most robust relationships between MetS components and cognitive and social functioning were found in both groups. In the MetS group, there was also evidence for a strong correlation between cognition and BP. The TG, FPG, elevated systolic BP and HDL best classified people with higher cognitive impairment, but the most accurate TG was the most accurate. Conclusions Specific MetS components are strongly associated with cognitive impairment across somatic and psychiatric disorders. Transdiagnostic, lifestyle-based therapeutic interventions aimed at that group have the ability to enhance health outcomes.

Source link: https://europepmc.org/article/MED/35359023


Pros and Cons of Telemedicine for Inherited Metabolic Disorders in a Developing Country During the COVID-19 Pandemic.

Introduction: The COVID-19 pandemic has resulted in significant changes in the health care industry. Experts advised that people avoid social isolation during the pandemic, and, consequently, the benefits of telemedicine became understood among patients with chronic diseases. Telemedicine's current report explores the level of satisfaction among patients with inherited metabolic disorders. Methods: This prospective research was conducted by utilizing a new video appointment service that protects the patient's privacy in video-based consultations. More than half of the parents who lived in another city complained about housing issues when arriving at the hospital, and most believed telemedicine would save them time and money for traveling. Conclusions: The current research is the most comprehensive cohort study to date assessing telemedicine in patients with IMDs, and it underscores the importance of telemedicine, particularly in developing countries during the COVID-19 pandemic.

Source link: https://europepmc.org/article/MED/35363077


Metabolic Disorders in Long-Living Patients with Coronary Artery Disease

Obesity was present in 31. 5 percent of patients, but not in one patient, grade III obesity. In 11. 2% of patients, an increase in the blood concentration of triglycerides was discovered. In 12. 7% of patients, the HDL cholesterol level decreased. In 23. 3% of cases, blood LDL cholesterol concentrations of less than 2. 0 mmol / l was found. Hyperuricemia was present in 37. 3% of patients, in 41. 4% of women and 28. 8% of men. In 45% of patients, an elevation in the serum creatinine level was noted. In 23. 1% of patients, an increase in fasting blood glucose level was discovered, but only 0. 9% of patients had glucose > 14 mmol/l. Conclusions: The study findings reveal some physiological signs of metabolic disease in long-living coronary artery disease patients. Patients with overweight or obesity were found in a large number.

Source link: https://europepmc.org/article/PPR/PPR474704

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions