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Metabolic disorder - Springer Nature

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Last Updated: 23 April 2022

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Prospective dietary radical scavengers: Boon in Pharmacokinetics, overcome insulin obstruction via signaling cascade for absorption during impediments in metabolic disorder like Diabetic Mellitus

Diabetes mellitus is a metabolic disorder that is specific to the blood glucose level. Vitamin C, E, ochrant, polyphenols, and selenium have been tested as antioxidant constituents in the human diet diet. This paper emphasizes the role of antioxidants, which can aid in lowering or maintaining the blood sugar levels in the body. Antioxidants are chemicals that protect the cells caused by free radical damage. In this paper, a different class of antioxidants and their therapy in curing the disease is further explored.

Source link: https://doi.org/10.1007/s40200-022-01038-8


Clinical diagnosis of metabolic disorders using untargeted metabolomic profiling and disease-specific networks learned from profiling data

Untargeted metabolomics is a worldwide molecular profiling system that can be used to search for metabolic abnormalities in infants. We used CTD, an automated diagnostic tool that “c onnects t he d ots” between metabolite variations observed in individual metabolomics profiling results and modules established in disease-specific metabolomics co-perturbation networks learned from prior profiling results. To provide more network-quantified predictors for use in diagnosis, we also extended CTD to determine distances between any two individuals and between an individual and a disease state. CTD can increase the speed and reliability by which clinical laboratory directors make diagnostic and treatment decisions by automating and quantifying perturbation patterns, as well as increasing results with new case studies.

Source link: https://doi.org/10.1038/s41598-022-10415-5


Cord blood metabolomics reveals gestational metabolic disorder associated with anti-thyroid peroxidase antibodies positivity

Background Thyroid disease is one of the common endocrine disorders affecting pregnant women, in which thyroid autoimmunity can influence pregnancy progression and pregnancy outcomes. Women with euthyroid status but anti-thyroid peroxidase antibodies positivity before pregnancy are vulnerable to subclinical gestational hypothyroidism. Methods We carried out 1H-NMR metabolomics on cord blood of a nested case control cohort of 22 pregnant women with similar thyroid hormone levels and demographic data, including 11 women with euthyroid dysfunction and demographic information, but anti-thyroid antibodies positivity and 11 matched women with euthyroid antibodies positivity and 11 matched women with matched thyroid hormone levels and demographic characteristics, including 11 women with euthyroid hormone levels and demographic information, including 11 women with matched women with thyroid hormone receptor antibodies in metabolomics Conclusions The findings of this research showed that fetal metabolic disorder is correlated with anti-TPO antibodies positivity, resulting in abundant variation of hypothyroidism-associated metabolites and the related disruption of amino acid metabolism pathways.

Source link: https://doi.org/10.1186/s12884-022-04564-8

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions