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Metabolic disorder - Crossref

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Last Updated: 23 April 2022

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Clinical diagnosis of metabolic disorders using untargeted metabolomic profiling and disease-specific networks learned from profiling data

Abstract Untargeted metabolomics is a global molecular profiling technique that can be used to look for inborn metabolic abnormalities. We employed CTD, an automated diagnostic method that “c onnects he d ots” between metabolite fluctuations observed in individual metabolomics profiling results and modules identified in disease-specific metabolomics co-perturbation networks derived from prior profiling results. To provide additional network-quantified predictors for use in diagnosis, we also expanded CTD to determine distances between any two people and between an individual and a disease state. CTD can raise the speed and stability by which clinical laboratory directors make diagnostic and treatment decisions by automating and analyzing perturbation patterns, as well as increasing success with new case studies.

Source link: https://doi.org/10.1038/s41598-022-10415-5


The Role of Magnesium in the Pathogenesis of Metabolic Disorders

It is involved in several basic functions, and Mg deficiency is often associated with poor health outcomes. On the one hand, most western civilizations consume less than the recommended daily allowance of Mg. , insulin resistance, and type 2 diabetes mellitus, hypertension, increased blood pressure, and low-grade inflammation have all been implicated in various metabolic disorders such as overweight and obesity, insulin resistance, diabetes mellitus, Type 2 diabetes mellitus, obesity, and type 2 diabetes mellitus. Chronic metabolic problems can be prevented by a high Mg intake via diet and/or supplementation.

Source link: https://doi.org/10.3390/nu14091714

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions