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Metabolic - U.S. Department of Veterans Affairs

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Last Updated: 15 June 2022

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Hexokinase 1 cellular localization regulates the metabolic fate of glucose.

"We produced mice lacking the HK1 MBD to clarify the effects of HK1 mitochondrial dissociation on cell metabolism. " GAPDH nitrosylation via iNOS is mediated by the coupling of cytosolic HK1 with S100A8/A9, resulting in GAPDH nitrosylation through iNOS. Lastly, human and mouse macrophages from conditions of low-grade inflammation, such as ageing and diabetes, increased cytosolic HK1 expression and reduced GAPDH activity. Through regulation of GAPDH, HK1 mitochondrial binding alters glucose metabolism, according to our results.

Source link: https://doi.org/10.1016/j.molcel.2022.02.028


Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits.

"Posttraumatic stress disorder is a psychological disorder that can arise as a result of a severe traumatic occurrence and is classified in three key symptom clusters per the Diagnostic Manual of Mental Disorders. " In this research, we characterized the biological variability of PTSD symptom clusters by combining genetically linked gene, splicing, and protein expression in dorsolateral prefrontal cortex tissue from a sample of veterans of the Million Veteran Program, according to this report. "We also checked for local genetic correlations within PTSD symptom clusters that highlighted metabolic and laboratory characteristics. ".

Source link: https://doi.org/10.1038/s41380-022-01488-9

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions