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Metabolic - Europe PMC

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Last Updated: 15 May 2022

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Exhaled metabolic markers and relevant dysregulated pathways of lung cancer: a pilot study.

Introduction The clinical application of lung cancer detection based on breath analysis is also problematic due to a lack of objective molecular markers in exhaled breath. Using a common method for metabolomics research, this research investigated potential lung cancer biomarkers and their related pathways. GC-MS measured breath samples from 60 lung cancer patients and 176 healthy people. Discussion Some of them are related to lung cancer risk factors or treatments. In studies based on genome or transcriptome results, however, more of them are dysregulated pathways of lung cancer. Conclusion We believe that using metabolomics techniques to analyze data of exhaled breath can help analyze samples of exhaled breath and promotes knowledge of more volatile metabolites. Immediate lung cancer detection based on breath test results The clinical application of lung cancer detection based on breath test results is still challenging, despite disease heterogeneity and a lack of predictive molecular markers in exhaled breath, according to a series of related research. Key findings of the present study revealed that 11 pathways involving 8 potential biomarkers were found to be dysregulated pathways of lung cancer, which may lead to reduced mortality in the future. As a result, respiratory cancer risk reduction may be reduced in future.

Source link: https://europepmc.org/article/MED/35261323


MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granules.

Through screening, we discovered that non-structural protein 1 of MERS-CoV might inhibit cell proliferation, cell cycle, and cell migration, as well as cell migration by its endonuclease activity. Interestingly, the nsp1-located granules contained mRNAs of ribosomal protein genes and oxidative phosphorylation genes, which may explain why MERS-CoV nsp1 degraded these mRNAs in cells selectively in cells. These results reveal a new way by which MERS-CoV impairs cell viability, which may be a new avenue for preventing MERS-CoV infection-induced pathological damage.

Source link: https://europepmc.org/article/MED/35129074


S1P/S1PR3 signalling axis protects against obesity-induced metabolic dysfunction.

Compared to low fat diet-fed peers, insulin levels in obese C57BL/6 J mice' S1PR3 gene expression was elevated in adipose tissues and liver. Weight gain in both S1PR3-/- mice and WT littermates was similar on a HFD; however, HFD-fed S1PR3-/- mice developed partial lipodystrophy, exacerbated insulin resistance, and glucose intolerance, which was inconsistent on a HFD. In 3T3-L1 preadipocytes, increased adipogenesis, and S1P-S1PR3 signalling restricted the expression of PPAR, suggesting a new role for this signalling pathway in the adipogenic regimen.

Source link: https://europepmc.org/article/MED/35094654


Adipose endothelial cells mastering adipose tissues metabolic fate.

It has been reported recently that adipose endothelial cells serve as vital bridges for biological communication between adipose-resident cells. AdECs' differentiable regulation in adipose plasticity is often based on vascular density and metabolic states. Although choosing pro-angiogenic or anti-angiogenic drugs for obesity is still a topic of discussion in clinical settings, increasing numbers of drugs have been shown to have an anti-obesity role by affecting vascularization.

Source link: https://europepmc.org/article/MED/35067158


Neutrophil Gelatinase-associated Lipocalin (NGAL) as a Marker of Renal Tubular Injury in Metabolic Syndrome Patients with Hyperuricemia.

Background Hyperuricemia has long been associated with chronic kidney disease, but studies show that hyperuricemia may play a role in renal damage progression. It's unclear if hyperuricemia can result in renal tubular injury in renal tubular dysfunction. Hyper or normoplasticemia in metabolic syndrome patients have elevated or normocorticemia in this review. Using a commercially available enzyme-linked immunosorbent assay kit, clinical biochemical parameters of serum NGAL and urinary NGAL were determined. The sensitivity and specificity of serum NGAL and urine NGAL/creatinine ratio was determined by an analysis. In metabolic syndrome patients with hyperuricemia, the serum NGAL levels and Urinary NGAL/creatinine ratio were elevated. Conclusions derived from the serum NGAL and urinary NGAL/creatinine ratio in metabolic syndrome patients with hyperuricemia, which indicates the presence of renal tubular injury in these patients.

Source link: https://europepmc.org/article/MED/35057593


A comprehensive study on the relieving effect of Lilium brownii on the intestinal flora and metabolic disorder in p -chlorphenylalanine induced insomnia rats.

Context The bulb of Lilium brownii F. E. Brown is a common Chinese medicine to treat insomnia. Results Following LB treatment, the increased incidence and diversity of intestinal flora and faecal metabolic phenotype altered by PCPA in rats were reversed, as shown by the up-regulated level of NET as 8. 14 ng/mL, and the increase of pathological characteristics of cells in the hypothalamus, as shown by the improvement of pathological characteristics of cells in the hypothalamus. In addition, it was also discovered that LB had reduced the concentrations of kynurenic acid related to psychiatric disorders and trimethylamine-N-oxide associated with cardiovascular disease. Conclusion The LB's relieving insomnia treatment involves regulating flora and metabolites to mimic the control group's. LB could be used as a medicinal and edible herb to help with insomnia in the future.

Source link: https://europepmc.org/article/MED/34978949

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions