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Metabolic - DOAJ

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Last Updated: 15 May 2022

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Uncovering in vivo biochemical patterns from time-series metabolic dynamics

System biology depends on holistic biomolecule measurements, and untangling biochemical pathways necessitates time-series metabolomics profiling. With current metabolomic techniques, time-series measurements can be taken for hundreds of metabolic characteristics, which determine regulatory control. Mechanistic modeling can also be more cumbersome computationally due to the high dimensionality of the metabolic space. Based on results obtained by Ridge Tracking-based Extract on experiments from ongoing in vivo measurements of metabolism by NMR in Neurospora crassa under different conditions, different conditions were extracted by Time-series metabolic characteristics. We'll continue expanding incomplete metabolite annotations using a correlation network next. Lastly, we discovered meaningful metabolic clusters by estimating dependencies between smoothed metabolic profiles. In N. crassa, dense's links with glucose 1-phosphate highlighted its central role in metabolism. Our study was based on simulated random network dynamics and provides a new exploratory approach to analyzing high-dimensional metabolic dynamics.

Source link: https://doaj.org/article/f5c532fa392a46f0ac85286c0f3c0d1d


Improved heat coefficients for joint-space metabolic energy expenditure model during level, uphill, and downhill walking.

We develop an optimization problem and solve it with the particle swam method plus fmincon function in MATLAB to find a new optimal weighting parameter set for each grade that results in more accurate predicted MEE, and we compare our new findings with seven other MEE models in the literature. The new analysis matched the measured MEE with the lowest RMSE values for level and downhill walking, as well as the third lowest RMSE value for uphill walking, where another MEE model, Looney et al. , had the lowest RMSE for uphill walking.

Source link: https://doi.org/10.1371/journal.pone.0267120


Multiple metabolic comorbidities and their consequences among patients with peripheral arterial disease.

Older adults with peripheral arterial disease have an elevated risk of major cardiovascular events and hospitalization. This research was designed to find out how multiple metabolic syndromes may influence the risk of adverse health outcomes among older adults with PAD. Using administrative claim data from the Health Insurance Review and Assessment Service Agency, a retrospective cohort study was adopted. The research included 3,122 older adults with at least one PAD diagnosis in an inpatient setting from 2011 to 2013 with at least one follow-up visit after hospitalization by 2018. PAD patients with higher metabolic comorbidities had shorter MACE-free and MALE-free intervals, according to a study by Kaplan-Meier survival curves. In addition, the healthcare utilization pattern should be considered when planning preventive care for older patients with comorbidities to treat PAD at an earlier stage.

Source link: https://doi.org/10.1371/journal.pone.0268201


Liver Endothelial Heg Regulates Vascular/Biliary Network Patterning and Metabolic Zonation Via Wnt SignalingSummary

We wanted to investigate Heg's role in mammalian liver formation and functional maintenance. Methods: For the study of Heg's liver function, either global or liver endothelial cell-specific deletion of Heg mice was used. Results: Heg deficiency in liver ECs resulted in a sparse liver vascular and biliary network. This network paucity does not affect liver function under baseline conditions, but it did change liver zonation. Endothelial Heg, according to our report, is vital for 3-D patterning of the liver vascular and indirect control of proper liver zonation by the control of Wnt ligand production in liver endothelial cells. The endothelial Heg-initiated changes of the liver metabolic zonation and metabolic enzyme expression in hepatocytes were physiologically relevant to xenobiotic metabolism and drug-induced liver toxicity, according to xenobiotic metabolism and drug-induced liver toxicity.

Source link: https://doi.org/10.1016/j.jcmgh.2022.02.010


Litter expansion alters metabolic homeostasis in a sex specific manner.

At 15 months of age, male LS10 & 12 mice showed significant reductions in their fat depot masses, both subcutaneous and brown fat, although females did not follow these findings. Both male LS12 mice demonstrated improved glucose tolerance at 9 months of age, and male LS12 mice displayed improved insulin tolerance beginning at 5 months of age, at 9 months of age. In addition, we found that the male LS8, 10 & 12 mice at 15 months of age had significantly reduced IGF-1 levels in the serum and various other organs. In the same manner, the litter expanded mice showed sex specific response to FGF21 and adiponectin levels at 15 months of age, with only the male mice displaying elevated FGF21 and adiponectin levels at 15 months old.

Source link: https://doi.org/10.1371/journal.pone.0237199


Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish

We carefully examine zebrafish in a long-term obesogenic environment, as well as zebrafish that were subjected to early lifetime caloric restriction. Malnutrition in early life has been attributed to an increased risk of disease and an exacerbation of metabolic syndrome, in contrast, fish that were strictly restricted from five days after fertilization to three to nine months of age did not have signs of an exacerbated phenotype. The groups that were transitioned later in life from caloric restriction to the obesogenic environment did not completely adhere to the long-term obesity group by the time of our study.

Source link: https://doaj.org/article/1e8d124613594d159491a9d99ae36d61


Evolution under fluctuating environments explains observed robustness in metabolic networks.

In several organisms, a high degree of robustness against gene deletion is present. Robus emerges as a result of selection for biomass production in various cultures, according to one hypothesis, which is particular to metabolic networks. We performed evolutionary simulations of metabolic networks in a range of stable and fluctuating environments to prove this assertion. We found that networks that have evolved under the new conditions can be able to tolerate single gene deletion in particular environments. Observed robustness in networks developed under transitional environments was "apparent," in the sense that it reduced significantly as we tested the effects of gene deletions in all environments experienced during evolution. These results show that evolution in biological environments may be responsible for metabolic networks' apparent robustness. Organisms in their digestive networks should be less robust, they say, and that robustness should decrease when moving to more stable environments.

Source link: https://doi.org/10.1371/journal.pcbi.1000907


Association of Serum Retinol Concentrations With Metabolic Syndrome Components in Iranian Children and Adolescents: The CASPIAN-V Study

paraphrasedoutput:Methods is a website that publishes articles about adults and adolescents. This was the first attempt to determine the relationship between serum retinol concentration and the presence of metabolic syndrome genes in children and adolescents. The association of serum retinol concentration with metabolic syndrome components was determined by multivariable logistic regression, with 49% of participants being girls. Vitamin A deficiency was detected in 19. 7% of study participants, and serum retinol concentration was 1. 48 1. 55 mol/L. However, there was no statistically significant connection between metabolic syndrome and retinol concentrations, but not with metabolic syndrome itself.

Source link: https://doi.org/10.3389/fnut.2022.807634


Metabolomics Analysis Across Multiple Biofluids Reveals the Metabolic Responses of Lactating Holstein Dairy Cows to Fermented Soybean Meal Replacement

This experiment was conducted to determine dairy cows' metabolic responses to the substitution of soybean meal with fermented soybean meal. In a completely random setting, twenty-four lactating Chinese Holstein dairy cattle were sent to either the SBM group [the basal total mixed ration diet with 5. 7 percent SBM] or the FSBM group, with a purely random structure. When SBM was completely replaced by FSBM, the concentrations of a few medium-chain FA in milk increased sharply, although those of a few milk long-chain FA decreased sharply. Besides, the densities of urea nitrogen and lactic acid in the FSBM-fed cows were noticeably higher, while the glucose concentration was significantly lower in the blood of the SBM-fed cows than in the SBM-fed cows.

Source link: https://doi.org/10.3389/fvets.2022.812373

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions