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Metabolic - Astrophysics Data System

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Last Updated: 15 May 2022

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Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network

The estimated number of ATP molecules produced per pair of electrons donated to the electron transport system and energy-maintenance requirements was strictly in accordance with experimental findings. In aerobic and anaerobic cultures, complete whole-cell functions of growth and metabolic by-product secretion were consistent with experimental results, and thus mRNA expression profiles during metabolic shifts were calculated. Also, constraint-based analysis of a genome-scale metabolic network for the eukaryotic S. cerevisiae aids in the estimation of its integrated functions, resulting in silico results that were consistent with observed phenotypic functions for 70-80% of the conditions considered.

Source link: https://ui.adsabs.harvard.edu/abs/2003PNAS..10013134F/abstract


Supply-demand balance and metabolic scaling

As body mass increases, the metabolic demand per unit mass decreases therefore decreases. Both the ability of the organism's transport system to supply metabolites to the tissues and the rate at which tissues use them are used are both reflected in the metabolic rates. We show that the ubiquitous 3/4 power law for interspecific metabolic scaling evolved from simple, general geometric properties of transportation networks constrained to function in biological organisms. When mass-specific metabolic demands meet the network's evolving delivery capacities at various body sizes, the 3/4 exponent and other observed scaling relationships occur.

Source link: https://ui.adsabs.harvard.edu/abs/2002PNAS...9910506B/abstract


A whole-body multi-scale mathematical model for dynamic simulation of the metabolism in man

We recommend a complete body model of man's metabolism as well as a generalized framework for modeling metabolic networks. We are able to create a large metabolic network in a cost-effective and convenient way by using this technique. In order to simulate metabolite concentrations during the feed-fast cycle, we have started ingestion of food. Due to the inclusion of storage options, the model can be depleted if food is not consumed regularly. In virtual clinical trials, a physiological model that incorporates intricate cellular metabolism and whole-body mass dynamics can be used.

Source link: https://ui.adsabs.harvard.edu/abs/2022arXiv220501473C/abstract


Deep Metabolic Profiling Assessment of Tissue Extraction Protocols for Three Model Organisms

Although metabolic methods have been used on model organisms before, no systematic evaluation of various organisms and sample types has been conducted to optimize metabolite extraction. Using a highly standardized metabolic profiling assay analyzing 630 metabolites from three commonly used model organisms to determine the best extraction procedure for various matrices is used to solve this problem. In mouse kidney samples, 509 in mouse liver, 422 in zebrafish, and 388 in Drosophila, we were able to identify up to 530 metabolites, with a core overlap of 261 metabolites in these four matrices. We have embedded our data set in the open-source shiny app "MetaboExtract" to encourage other scientists to search for the most appropriate extraction technique in their experimental context and interact with this rich data.

Source link: https://ui.adsabs.harvard.edu/abs/2022FrCh...10.9732G/abstract


Evolutionary dynamics at the tumor edge reveal metabolic imaging biomarkers

We collected 18 F-FDG PET photographs of breast cancers and non-small-cell lung cancers, where we measured the distance from the point of maximum activity to the tumor centroid, normalizing it by a survivor of the volume.

Source link: https://ui.adsabs.harvard.edu/abs/2021PNAS..11818110J/abstract


Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution

Inherently poor sensitivity, which limits the procedure for the most part to determining water molecules in the body, hinders magnetic resonance imaging. Hyperpolarized molecules have markedly enhanced MRI signals, opening the door to imaging low-concentration animals in vivo. In this research, we were able to solve these setbacks in the production of PHIP-polarized [1-13 C]fumarate, a cell necrosis biomarker in metabolic 13 C MRI.

Source link: https://ui.adsabs.harvard.edu/abs/2021PNAS..11825383K/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions