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Meperidine - DOAJ

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Last Updated: 20 April 2022

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Effect of Intravenous Meperidine in Controlling Post Dural Puncture Headache

In patients suffering from PDPH, the therapeutic effects of conventional therapy are being compared to intravenous meperidine. In group P, there were significantly less time to experience severe headaches within three hours after starting of therapy than in group A; however, group C had more rapid and effective outcomes than group C.

Source link: https://doaj.org/article/b20030df3a2c460683d3806e6dadcc34


Evaluating the Effect of Intrathecal Sufentanil and Meperidine on Shivering after Caesarean Section Under Spinal Anesthesia

Shivering patients after a caesarean section has been documented by the present research. For the first group, 2 cc of bupivacaine and 2. 5 g of Sufentanil were used, 2. 5 g of Sufentanil were used, 2. 5 g of Sufentanil for the second group, 25 mg of Meperidine for the second group, and a 2. 5 cc normal saline for the control group. Shivering's mean score in the Meperidine group was significantly lower than those in the Sufentanil group and the control group, according to the Meperidine group. In Meperidine and Sufentanil groups, the incidence of shivering was also reduced in comparison to the control group. Blood pressure dropped from the 25th minute to the 45th minute of the operation, and during the first 45 minutes of the recovery, there was more stability in the Meperidine and Sufentanil groups.

Source link: https://doaj.org/article/b58b95c56aa142d3acfb86b425ff34ac


The effects of Adding Meperidine to Heavy Intrathecal Lidocaine on Hemodynamic Changes and Blood Loss in Open Prostatectomy: A Randomized Double-Blind Clinical Trial

Patients undergoing elective suprapubic open prostatectomy were found to have hemodynamic changes and blood loss when adding meperidine to intrathecal heavy lidocaine. Methods: Seven patients candidates for elective suprapubic open prostatectomy were divided into two separate groups in a randomized double-blind clinical trial. In the experiment group, a small dose of meperidine was added to lidocaine. Changes in blood pressure and heart rate were measured and recorded in several intervals. Patients of the control group were more prevalent right away in the post-operative period. In the experimental group, there were much less post-operative bleeding and need to transfusion, but there were no effects on blood pressure change in the operating room, but there were no changes in blood pressure change in the post-operative period, which prevented increasing blood pressure in the post-operative period with a decrease in bleeding.

Source link: https://doaj.org/article/b1272b6374f8497eb0807d6d61683d22


Intrathecal Meperidine for Prevention of Shivering During Transurethral Resection of Prostate

Materials and Methods: 80 patients scheduled for TURP under spinal anesthesia were divided into two groups of case and control in a randomized controlled trial. In the case group and the same dose of lidocaine plus normal saline in the control group's patients, spinal anesthesia was administered using 75 grams of hyperbaric lidocaine 5% plus meperidine, 15 mg. Findings: The maximum amount of sensory blockage was similar in both the case and control groups. Shivering was not present in the patients who received meperidine, but in the control group, 11 people died from different degrees of shivering. The side effects of opioids were unremarkable. Conclusion: Low-dose intrathecal meperidine is both safe and efficient in reducing the incidence of shivering associated with spinal anesthesia for TURP.

Source link: https://doaj.org/article/98c56b9f2e3342b4bd937e04c21ffc4b


Prophylactic effects of intrathecal Meperidine and intravenous Ondansetron on shivering in patients undergoing lower extremity orthopedic surgery under spinal anesthesia

The aim of this review was to compare the prophylactic results of intravenous ondansetron with intrathecal meperidine on the prevention of shivering in patients undergoing spinal anesthesia after spinal anesthesia. Before spinal anesthesia, respectively, spinal anesthesia was administered to IV ondansetron 8 mg and IT meperidine 0. 2 mg/kg by Group O and Group M. Compared to Group C, there was a substantial difference between Group O and M and Group C. Group M's shivering incidence and severity were significantly lower than Group O. Of the 15 patients who were from Group C, six patients from Group O, and one patient from Group M required additional IV meperidine, two patients were from Group C, six patients from Group O, and one patient from Group M. Conclusion: We found that IT meperidine and IV ondansetron reduces the frequency and severity of shivering in comparison to the control group, as well as decreasing the demand for additional doses of meperidine for shivering the control without any hemodynamic side effects.

Source link: https://doi.org/10.4103/2279-042X.141105


Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial

We compared the safety of meperidine and two low doses of ketamine with placebo to avoid postanesthetic shivering after general anesthesia. This was a prospective, randomized placebo controlled clinical trial involving 120 ASA I-II patients aged 20-to-gold, who underwent endoscopic sinus surgery with general anesthesia, which was a prospective, randomized double-blind placebo controlled clinical trial. Statistical Package for Social Sciences Windows version 16. 16 was used to perform statistical analyses. According to Groups M, K 1, K 2, and N, respectively, the number of patients with observed shivering in groups was 0, 3, 1, and 9. With Group N, the difference between groups M, K 1, and K 2 was statistically significant. However, the differences between M and K 1, M and K 2, and K 1 and K 2, were not significant. In Group N, the number of patients with a shivering score of 2 or 3 was higher than in other groups.

Source link: https://doaj.org/article/7617825872574784bec7c2970d153203


Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Meperidine is a synthetic opioid that belongs to the phenylpiperidine class and is a poor mu receptor agonist. There are a limited number of published research describing the analgesic effects of systemically administered meperidine in horses. Three doses of intravenously administered meperidine to horses were used to describe the pharmacokinetics, socioeconomic, and physiologic effects as well as their effect on the thermal threshold of three doses of intravenously administered meperidine to horses. A randomized balanced cross-over system was used by Eight University's horses four mares and four geldings aged 3–8 years were tested for eight years, four geldings and four geldings, aged 3–8 years. Meperidine and normeperidine were tested for meperidine and normeperidine by liquid chromatography-mass spectrometry and plasma pharmacokinetics, according to investigators. The effect of meperidine administration on thermal nociception was determined and thermal excursion calculated. Conclusions of the new study The results of the new research indicate that IV meperidine use in horses at a dose of 1 mg/kg are not appropriate.

Source link: https://doi.org/10.1186/s12917-020-02564-4


Famotidine-induced reversal of meperidine-related serotonin syndrome: a case report

This case review is the first study to discuss the potential treatment effects of famotidine on serotonin syndrome. This is also the first case report of serotonin syndrome caused by meperidine alone in a patient with no previous history, pointing to a susceptibility to serotonin syndrome. Following ureteroscopy, a 70-year-old male with no prior history of serotonergic drug use developed severe serotonin syndrome, possibly due to postoperative meperidine administration. The histamine type 2 receptor antagonist famotidine, according to this case report, may be an effective emergency treatment for serotonin syndrome.

Source link: https://doi.org/10.4097/kjae.2017.70.2.221


Sedation for Colonoscopy: A Double-Blind Comparison of Diazepam/Meperidine, Midazolam/Fentanyl and Propofol/Fentanyl Combinations

Patients were randomly assigned to receive diazepam and meperidine, midazolam, and fentanyl, or propofol and fentanyl with a continuous infusion of propofol. There were no differences in the rate of recovery or occurrence of minor side effects among the three groups. Following administration of sedatives, over 80% of patients required supplemental oxygen due to persistent desaturation below 85 percent. The authors' comment that oxygen should be given to all patients undergoing colonoscopy.

Source link: https://doi.org/10.1155/1994/259528


Endobronchial ultrasound-guided transbronchial needle aspiration under conscious sedation with meperidine and midazolam

Endobronchial Ultrasound guided transbronchial needle aspiration is often done under general anesthesia or deep sedation with drugs like Propofol, but not in Italy, and can only be administered by an anesthesiologist. The aim of the study was to determine conscious sedation efficiency, safety, and tolerability using Meperidine and Midazolam as administered by Pulmonologist, with a direct effect on the sampling procedures' effectiveness. All patients undergoing EBUS-TBNA from February 2013 to July 2014 were reviewed retrospectively. During EBUS-TBNA, performance using Meperidine and Midazolam has been assessed: completion of lymph nodal sampling, sampling adequacy, diagnostic accuracy, cough during endoscopic procedure complications, and the need for procedure repeating with Anesthesiology assistance. In 94 percent of cases, cough was absent or did not interfere with EBUS-TBNA. Patient satisfaction was remarkably high, with 98% of respondents saying they would "definitely return" after 95% of patients.

Source link: https://doi.org/10.4081/monaldi.2017.768

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions