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Methods Healthy women with singleton term pregnancy were requesting analgesia during active labour were investigated. Women were randomly chosen to receive 50 mg meperidine, 1 mg butorphanol, or 25 mg meperidine plus 0. 5 mg butorphanol. Butorphanol alone did not reduce pain affective magnitude, whereas other drugs did not, whereas the other therapies did not. In both groups, there was a strong correlation between pain reduction and affective magnitude, with greater decreases in affective magnitude than intensity in both groups. Overall, 29 percent of women received clinically meaningful pain relief, with no difference between groups. Conclusions These doses of meperidine and butorphanol do reduce pain and affective magnitude, but a minority of patients receives meaningful pain relief in many patient populations, including laboring women.
Source link: https://doi.org/10.1097/00000542-200505000-00021
Background Meperidine was found to be more effective in treating shivering than equianalgesic doses of other opioids, especially pure mu-agonists. The authors investigated nonopioid receptor-mediated meperidine-induced thermoregulation in a mice model of nonshivering thermogenesis. The authors tested wild-type mice and knock-out mice with deletion of the alpha2A-, alpha2B-, or alpha2C-adrenoceptor subtype specific responses, determining if alpha2A-, alpha2B-, or alpha2C-adrenoceptor subtype specific interactions. Methods Ten mice per group were injected with saline, meperidine, saline plus naloxone, meperidine plus naloxone, fentanyl plus naloxone, fentanyl plus naloxone, fentanyl plus naloxone, meperidine, or meperidine plus atipamezole intraperitoneally with meperidine plus naloxone, Meperidine lowered the thermoregulatory threshold temperature in wild-type mice and alpha2B- and alpha2C-adrenoceptor knock-out mice, according to the study. No decrease in thermoregulatory threshold following meperidine injection was detectable in alpha2A-adrenoceptor knock-out mice. Conclusions The authors' findings suggest a central role of alpha2-adrenoceptors, especially the alpha2A subtype, in the mediation of thermoregulatory responses in mice caused by meperidine.
Source link: https://doi.org/10.1097/aln.0b013e31817c02fc
Epidural analgesia is one of the best pain relief for many pregnant women in labor. This research was done to determine the effect of epidural analgesia administered by a combination of bupivacaine plus meperidine or fentanyl on the mother, fetus, and labor process in term nulliparous women. If the patient wanted analgesia, the BM team received a loading dose of 16 ml bupivacaine 0. 12 percent plus 20 mg meperidine followed by an intermittent bolus of the same treatment. The pain score was significantly lower in the meperidine group compared to the fentanyl group during labor after the intervention, compared to the fentanyl group during labor. This report found that epidural meperidine may be a safe alternative to fentanyl for pain relief and shortening the active phase of delivery without raising the risk of the neonatal low Apgar score.
Source link: https://doi.org/10.18502/acta.v60i3.9002
Hypothermia could be especially helpful in stroke victims, according to the source and purpose, but even mild hypothermia leads to shivering. Meperidine and dexmedetomidine gradually reduced the shivering threshold with little sedation. We tried the possibility that meperidine and dexmedetomidine synergistically reduced the shivering threshold without causing significant sedation or respiratory depression. Methods — We reviewed ten healthy male volunteers on four days: control; meperidine ; dexmedetomidine ; and metperidine plus dexmedetomidine — We surveyed ten healthy male volunteers on four days: control; meperidine ; dexmedetomidine ; dexmedetomidine ; and dexmedetomidine — and meperidine plus dexmedetomidine — we collected — The lactated Ringer's solution was infused through a central venous catheter to reduce tympanic membrane temperature by 2. 5°C/h; mean skin temperature was held at 31°C. Results—The study days were marked by the following: control, 36. 70. 3°C; dexmedetomidine, 36. 0°C; meperidine, 35. 5°C; and meperidine plus dexmedetomidine, 34. 7–0. 6°C; and meperidine plus dexmedetomidine, 34. 7°C; respectively: 3. 6°C; and meperidine, 34. 70. 6°C; xmedetomidine, Both days, the respiratory rate and end-tidal P co 2 were well preserved.
Source link: https://doi.org/10.1161/01.str.0000068787.76670.a4
The effects of the isolated umbilical artery's reaction to acetylcholine and/or 5-hydroxytryptamine were investigated by oxytocin and meperidine. The Bunce double-blade hemostat was an excellent way to collect cord specimens with the least postpartal variations. oxytocin improved the response of the umbilical artery to ACh and 5-HT, according to ACh and 5-HT, while meperidine stopped the constriction produced by 5-HT.
Source link: https://doi.org/10.1159/000240883
Following meperidine administration in a control group, the incidence of fetal or neonatal depression was higher than in a control group, but there was no association between suppression and meperidine administration or serum meperidine concentrations at the time of delivery.
Source link: https://doi.org/10.1159/000241055
i. v. In rhesus monkey infants whose dams received 0,2, or 3 mg/kg meperidine, i. v. ), potential long-term consequences of intrapartum meperidine were investigated. During the first phases of the first reversal, drug-exposed infants had more balks and fewer correct choices during the initial phases of the discrimination reversal test. During the second half of the test period, drug-exposed infants did better and had fewer omission errors during the continuous performance assessment.
Source link: https://doi.org/10.1159/000244155
In 80 percenturients undergoing caesarean section, this research compared intrathecal hyperbaric bupivacaine to low-dose intrathecal plain bupivacaine plus different doses of meperidine, causing blood pressure stability, post-operative analgesia, and incidence of side effects. Without impacting quality of anesthesia or surgical satisfaction, patient satisfaction, sequential administration of 5 mg plain bupivacaine and 25 mg meperidine intrathecally delivered improved blood pressure stability and a reduced risk of side-effects than bupivacaine alone.
Source link: https://doi.org/10.1177/147323001003800507
Purpose of Abstract Purpose With meperidine, there have been growing concerns about adverse effects and drug interactions, as well as its removal from the World Health Organization's list of essential drugs. In the United States, the aim of this research was to identify pharmacoepidemiological trends in meperidine use. Methods Meperidine distribution data was obtained from the Drug Enforcement Administration's Automated Orders System's Automated Reports and Consolidated Orders System. In 2017, physicians of family medicine and internal medicine accounted for 28. 9% and 20. 5% of Medicare Part D's total daily supply of meperidine. Interventional pain management and pain management physicians accounted for the longest TDS per provider, though family medicine and internal medicine accounted for the shortest TDS per provider. The majority of meperidine daily supply was still available, according to primary care physicians, but interventional pain specialists were the most likely to prescribe meperidine to Medicare patients.
Source link: https://doi.org/10.1101/2020.11.30.20241182
For all items except tone and Moro responses at 24 hours, Babies who were not exposed to meperidine showed a statistically higher risk of high scores than those exposed to meperidine alone for all items on the neurobehavioral scale at 2 and 4 hours and for all items except tone and Moro response at 24 hours. Similarly, babies whose mothers received meperidine and naloxone showed a significantly higher rate of high scores than those whose mothers received meperidine and naloxone alone at 2 hours of age. However, neonates exposed to meperidine and naloxone is depressed nearly as much as those who are not exposed to meperidine alone at 4 and 24 hours.
Source link: https://doi.org/10.1542/peds.62.3.294
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