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Meningitis - MedlinePlus Genetics

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Last Updated: 23 June 2022

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Complement component 8 deficiency

Deficiency of Complement 8 is a condition that causes the immune system to malfunction, resulting in a form of immunodeficiency. People with complement component 8 deficiency have a significant risk of recurrent bacterial infections, particularly with a bacterium named Neisseria meningitidis. Although meningitis can be life-threatening, people with complement component 8 deficiency are less likely to die from the disease than those in the general population. The severity of complement component 8 deficiency varies widely. Both types of complement component 8 deficiency are identified by their genetic cause.

Source link: https://medlineplus.gov/genetics/condition/complement-component-8-deficiency


Mannose-binding lectin deficiency

Mannose-binding lectin deficiency syndrome is a disease that affects the immune system. People with this disorder also have a lack of an immune system protein called mannose-binding lectin in their blood. People with mannose-binding lectin deficiency can cause infections of the upper respiratory tract and other bodily tissues. Infants and young children with mannose-binding lectin deficiency seem to be more susceptible to infections than adults, but adults can also get recurrent infections.

Source link: https://medlineplus.gov/genetics/condition/mannose-binding-lectin-deficiency


Complement component 2 deficiency

Immunodeficiencies are conditions in which the immune system is not able to shield the body effectively against foreign invaders such as bacteria and viruses. People with complement component 2 deficiency have a significant risk of recurrent bacterial infections, particularly of the lungs, the membrane covering the brain and spinal cord, and the blood, which can be life-threatening. Deficiency of Complement 2 is also linked to an elevated risk of developing autoimmune disorders such as systemic lupus erythematosus or vasculitis. SLE is a condition that causes deficits in between ten percent and 20 percent of people with complementary component 2 deficiency. Females with complement component 2 deficiency are more likely to have SLE than those without, but this is also true of SLE in the general population. The severity of complement component 2 deficiency varies widely.

Source link: https://medlineplus.gov/genetics/condition/complement-component-2-deficiency


MyD88 deficiency

MyD88 deficiency is an inheritable condition of the immune system. MyD88 deficiency leads to abnormally widespread and acute infections caused by a subset of bacteria identified as pyogenic bacterias. Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa bacteria are the most common infections in MyD88 deficiency. Most people with this condition have their first bacterial infection before age 2, and infections can be life-threatening in infancy and childhood. Inflammation-resistant bacterial infections that can affect the blood, the membrane surrounding the brain, spinal cord, or joints, can be present in children with MyD88 deficiencies. Invasive infections can also result in tissue breakdown and pus production on internal organs. Although fever is a common reaction to bacterial infections, many people with MyD88 deficiency do not have a high fever in response to these infections right away, even if the infection is serious.

Source link: https://medlineplus.gov/genetics/condition/myd88-deficiency


IRAK-4 deficiency

The most common infections in IRAK-4 deficiency are caused by Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa bacteria. Most people with IRAK-4 deficiency have invasive bacterial infections that can affect the blood, the membrane protecting the brain, and spinal cord, or the joints. Invasive infections can also result in tissue breakdown and pus production on internal organs. Although fever is a common reaction to bacterial infections, many people with IRAK-4 deficiency do not experience a high fever in response to these infections at first, even though the infection is chronic.

Source link: https://medlineplus.gov/genetics/condition/irak-4-deficiency


Isolated congenital asplenia

Isolated congenital asplenia is a disorder in which patients are missing their spleen but not other developmental abnormalities. In order to prevent infections, the spleen produces phagocytes, which help eliminate bacteria from the blood. The spleen also stores specific blood cells that fight foreign invaders until they are required, and removes old blood cells for removal. Since people with isolated congenital asplenia lack these immune functions, they are extremely susceptible to bacterial infections. People with isolated congenital asplenia are more vulnerable to serious, recurrent infections.

Source link: https://medlineplus.gov/genetics/condition/isolated-congenital-asplenia


Complement factor I deficiency

Deficiency of Complement Factor I deficiency is a disease that affects the immune system. Some people with a deficiency factor I deficiency have glomerulonephritis (Isolated C3 deposits) and glomerulonephritis. Deficiency may also be linked to autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus.

Source link: https://medlineplus.gov/genetics/condition/complement-factor-i-deficiency


Paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria is an acquired condition that results in premature death and diminished blood cell production. People with PNH have sudden, recurring episodes of illness, which can be triggered by physical or mental strains. Red blood cells are broken down earlier in these episodes than they should be. Hemoglobinuria is a form of hemoglobinemia. In many, but not all cases, hemoglobinuria is most noticeable early in the morning, following passing urine that has accumulated in the bladder during the night. The premature breakdown of red blood cells leaves the blood cells devoid of red blood cells, resulting in a blood cell shortage, prematurely puking, abnormally pale skin, shortness of breath, and an elevated heart rate. Because of a shortage of white blood cells, people with PNH can also be susceptible to infections. PNH abnormal platelets mixed with PNH can cause blood clotting difficulties. Individuals with PNH are at a higher risk of experiencing cancer in blood-forming cells. PNH is a common blood disorder that has been treated for another blood disorder, aplastic anemia, in some instances. PNH signs and symptoms in a small number of affected individuals die on their own. Inflammation is a common immune system reaction to injury and foreign invaders. The inflammatory disorders often appear earlier than blood cell abnormalities, although blood cell abnormalities usually appear first.

Source link: https://medlineplus.gov/genetics/condition/paroxysmal-nocturnal-hemoglobinuria

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions