Meningitis - Crossref

Bilateral Endophthalmitis in a Patient with Bacterial Meningitis Caused by Streptococcus pneumoniae

Aim: To present a patient with bilateral endophthalmitis as a result of Streptococcus pneumoniae meningitis. Methods: A 44-year-old man who was unconscious due to bacterial meningitis was referred to us for condromic hyperemia and reduced pupillary light reflexes. Results: Vision improved to 20/20 in the left eye one month after, but the right eye became hypotonic and blind. Vision in the left eye caused by a retinal detachment due to proliferative vitreoretinopathy, and vitreous surgery successfully reattached the retina. Vision returned to 20/20/80, and the retina has been on file for one year.

Source link: https://doi.org/10.1159/000149823

Clinical Reasoning: A 64-Year-Old Man With History of Meningitis Presenting With Proximal Weakness of the Arms

The patient's history was notable for severe Listeria monocytogenes meningitis 4 years before presentation, which was appropriately treated with antibiotics for several years. On examination, the cervicothoracic central cord was reassembled and localized to the cervicothoracic central cord. Blood results were unremarkable, and CSF findings showed no recurrent or persistent infection. Pockets of sequestered CSF from C3 to C4 and areas of CSF space effacement from C3 to T12 were found in Spinal MRI, from C3 to T12. The conus medullaris' postulated pathomechanism of cord tethering was revealed by a defective contrast agent migration above T10 and contour irregularities, which confirmed the postulated pathomechanism of cord tethering. Following bacterial meningitis, male central cord damage was likely due to cord tethering in the case of postinfectious adhesive arachnoiditis. The diagnosis of adhesive arachnoiditis may differ, and advanced imaging methods and invasive studies such as CT myelogram may be needed to establish the diagnosis.

Source link: https://doi.org/10.1212/wnl.0000000000013085

Safety and Efficacy of Liposomal Cytarabine in the Treatment of Neoplastic Meningitis

Objects: neoplastic meningitis has been increasingly present in patients with cancer due to the disease's long course. Methods: We reviewed all patients with NM from solid tumors or hematological malignancies treated with liposomal cytarabine at our hospital between March 2004 and September 2011. Conclusion: The increasing efficacy and safety data obtained in our research as well as the flexible administration schedule make intrathecal liposomal cytarabine a promising treatment option for NM patients.

Source link: https://doi.org/10.1159/000380913

Changes in Cerebrospinal Fluid Cytokine Expression in Tuberculous Meningitis Patients with Treatment

Background: In developing countries of the world, tuberculous meningitis is very widespread. Patients with TBM have long documented inflammation reactions and cytokines production in their cerebrospinal fluid. In CSF samples from TBM patients, the aim of the current study was to determine the presence of proinflammatory cytokine and anti-inflammatory cytokine levels. TBM patients before treatment had elevated levels of proinflammatory cytokines as compared to anti-inflammatory cytokines. However, CSF samples from TBM patients after treatment revealed elevated levels of anti-inflammatory and low amounts of proinflammatory cytokines.

Source link: https://doi.org/10.1159/000292023

Reversal of CSF HIV-1 Escape During Treatment of HIV-Associated Cryptococcal Meningitis in Botswana

paraccal meningitis with HIV-1 viral expulsion and HIV-1 viral load trajectories in people treated for HIV-associated cryptococcal meningitis. The phase-3 AMBITION-cm trial in Botswana used paired CSF and plasma data collected prior to and during the antifungal therapy of 83 participants. After CSF viral escape and HIV-1 VL trajectories were determined, HIV-1 RNA levels were quantified, CSF viral escape and HIV-1 VL trajectories were determined. HIV-1 VL de-creased markedly from day 1 to day 14 post antifungal therapy in the CSF, but not in the plasma.

Source link: https://doi.org/10.20944/preprints202205.0318.v1

Chronic Meningitis in Thailand

Chronic cryptococcal meningitis patients with HIV and other related diseases had a significant effect on the distribution of chronic cryptococy meningitis patients. Of the 43 patients with persistent tuberculous meningitis, only 3 were HIV positive. In tuberculous meningitis patients, there were more frequent deficiencies in tuberculous meningitis patients than in non-immigration patients without HIV. Cerebral infarction on cerebral CT showed tuberculous meningitis, according to a Cerebral infarction. Patients with HIV infection with Cryptococcal meningitis had a poorer outcome than non-AIDS patients.

Source link: https://doi.org/10.1159/000089236

Viral Meningitis-Associated Hospitalizations in the United States, 1988–1999

To determine disease burden associated with viral meningitis hospitalizations in the United States, we used the National Hospital Discharge Survey and the Nationwide Inpatient Sample of the Health Care Cost and Utilization Project.

Source link: https://doi.org/10.1159/000072924

Nationwide Population-Based Epidemiologic Study of Cryptococcal Meningitis in Taiwan

Background: In Taiwan, little is known about the epidemiology of cryptococcal meningitis. In Taiwan, the aim of this research was to conduct the first national population-based epidemiologic investigation of cryptococcal meningitis. From the annual hospitalization discharge claims of the National Health Insurance Research Database with the corresponding ICD-9 code 321. 0 from January 2000 to December 2007, there were cases of cryptococcal meningitis. Results: A total of 845 case cases of cryptococcal meningitis have been identified. 109 patients had human immunodeficiency virus infection, one of them. This is the first population-based epidemiologic investigation of cryptococcal meningitis in Taiwan.

Source link: https://doi.org/10.1159/000323390

Bacterial Meningitis: The Role of Transforming Growth Factor-Beta in Innate Immunity and Secondary Brain Damage

A deletion of TGF-u03b2 receptor II on leukocytes in mice with Streptococcus pneumonia-induced meningitis has been shown to increase neutrophil recruitment to the site of infection and promote bacterial clearance in mice with Streptococcus pneumoniae-induced meningitis. S. pneumoniae-induced vaping was almost eradicated from meningitis-induced vasculitis, a significant intracranial disease resulting in brain injury.

Source link: https://doi.org/10.1159/000100358

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions