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Meningitis - BioRxiv

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Last Updated: 11 January 2022

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Identification of a novel cationic glycolipid in Streptococcus agalactiae that contributes to brain entry and meningitis

Bacterial membrane layer lipids are vital for membrane bilayer formation, cell department, healthy protein localization, stress responses, and pathogenesis. Lys-Glc-DAG lugs two favorable net charges per particle, unique from the extensively described lysylated phospholipid Lysyl-phosphatidylglycerol which lugs one positive net charge because of the existence of a negatively billed phosphate moiety. GBS is a leading root cause of neonatal meningitis, which needs traversal of the endothelial blood-brain obstacle. We demonstrate that GBS strains doing not have mprF show a considerable decline in the capability to invade BBB endothelial cells. Further, mice challenged with a GBSDeltamprF mutant created bacteremia comparably to Wild-Type infected mice yet had much less recuperated germs from brain tissue and a lower occurrence of meningitis. Therefore, our information recommend that Lys-Glc-DAG may add to bacterial uptake into host cells and disease development.

Source link: https://doi.org/10.1101/2020.12.01.406702

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions