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Meniere's Disease - Europe PMC

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Last Updated: 15 August 2022

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Recovery of Unaided Hearing After Cochlear Implantation in Patient With Bilateral Menière's Disease.

Results Six-month postoperative unaided hearing in the implanted ear was in the moderate sensorineural hearing loss range, with a vocabulary recognition score of 95%, representing a significant improvement from preoperative hearing loss, despite unaided speech awareness threshold of 75 dB and inability to perform speech recognition testing. Unaided hearing improvement following cochlear implantation in a patient with MenioU00e8re's disease is surprising, but it may provide insight into the poorly understood underlying mechanisms of sensorineural hearing loss in patients with Meniu00e8re's disease.

Source link: https://europepmc.org/article/MED/35900913


Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease.

EH measurement in patients with MD patients is also useful for the determination of inner ear disorders. Patients with MD were tested using MRI and the HYDROPS protocol to determine the suitability of MRI for visualization of the endolymphatic space in the diagnosis of MD by comparing clinical laboratory results with EH classification. In 58 and 80% of 80 definite MD ears, 33 and 58% of 12 prospective MD ears, and 57% of 37 potential MD ears, respectively, were found in 5 and 80% of 80 percent of 80 definite MD ears, as well as in 5 and 27 percent of 37 potential MD ears. In both the cochlea and the vestibule, both PTA and LTA were markedly higher in patients with hydrops grade 2 than hydrops grade 0 in both the cochlea and the vestibule. Patients with grade 2 than grade 0 vestibular hydrops had significantly more CP in patients with grade 2 than grade 0 vestibular hydrops, which was much higher in patients with grade 2 than grade 0 vestibular hydrops.

Source link: https://europepmc.org/article/MED/35959407


Control of Disabling Vertigo in Ménière's Disease Following Cochlear Implantation without Labyrinthectomy.

Objective Background The placement of a cochlear implant can improve auditory function in the case of acute cochlear deafness, which may be related to Muci00e9niu00e8re's disease or related to endolymphatic hydrops. The typical treatment of disabling vertigo in MD is based on vestibular deafferentation as a result of labyrinth ablation. In the case of MD unresponsive to medical therapy, the aim of the current research was to retrospectively assess the CI's effectiveness in the detection of disabling vestibular abnormalities in the case of disabling vestibular manifestations. Methods The following is a case study of five MD patients with disabling vestibular disorders associated with profound hearing loss was included. In the case of disabling cochlear hydrops, we can therefore confirm the CI's effectiveness and safety as a unique treatment for hearing loss, dizziness, and tinnitus, particularly in those patients where the disease's history demands that vestibular function be preserved.

Source link: https://europepmc.org/article/MED/35892666


Transcriptional Down-Regulation of Major Histocompatibility Complex as a Possible Pathogenesis for Meniere's Disease.

Methods The RNA was extracted from the peripheral blood mononuclear cells of 39 patients with MD and 39 controls. The downregulated DEGs were highly enhanced in terms linked to immune system functions, according to a functional enrichment report. Human leukocyte antigen -DMA, HLA-DRB1, and HLA-DPB1] were significantly reduced in another 30 patients with MD with dramatically reduced relative messenger RNA levels compared to normal controls by quantitative reverse transcription chain reaction. Conclusions Our transcriptome report revealed that the downregulated DEGs in MD were mainly related to the immune system's functions, including the MHC protein complex in MD. Remarkably, an impairment of immunological tolerance mediated by MHC class II could contribute to MD formation, which has ramifications for targeted therapy.

Source link: https://europepmc.org/article/MED/35923832

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions