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Medulloblastoma - PubMed

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Last Updated: 24 July 2022

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KIF26B Is Overexpressed in Medulloblastoma and Promotes Malignant Progression by Activating the PI3K/AKT Pathway.

Medulloblastoma is one of the most common malignant tumors of the central nervous system in children. Although KIF2B was identified as an oncogene in several malignant tumor types, its role in medulloblastoma has not been investigated so far. The expression of KIF26B in Knockdown could severely hinder the proliferation and migration of medulloblastoma cells.

Source link: https://doi.org/10.1155/2022/2552397


Medulloblastoma in the Modern Era: Review of Contemporary Trials, Molecular Advances, and Updates in Management.

Despite medical and biological advancements, medulloblastoma patients from both age groups are affected by tumor- and treatment-related morbidity and mortality. Patients with high risk disease patients are requiring a new risk stratification strategy that incorporates both clinical and molecular measurements, ongoing research is trying to cautiously reduce therapy and reduce risk among low-risk patients, and steadily increase therapy by incorporating novel, biologically guided agents for patients with high-risk disease.

Source link: https://doi.org/10.1007/s13311-022-01273-0


Noncanonical activation of GLI signaling in SOX2+ cells drives medulloblastoma relapse.

The occurrence of astrocytic Sox2+ cells expressing sonic hedgehog signaling biomarkers was discovered by single-cell transcriptomic analysis of the most common malignant pediatric brain tumor, medulloblastoma. In these cells downstream of Smo in a MYC-dependent manner, we observed that SOX2+ cells required SHH signaling to propagate, and unlike in the proliferative tumor bulk. Our findings support the fact that chemotherapy targeting GLI will destroy SOX2+ cells and lead to stable tumor remission.

Source link: https://doi.org/10.1126/sciadv.abj9138


Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression.

Medulloblastoma is the most common primary malignant pediatric brain tumor disease. We recently reported new MEK/MAPK pathway in controlling human Sonic Hedgehog MB tumorigenesis. Following combination drug therapy, multiplex spatial profiling of proteins in drug-treated xenografts has revealed morphed molecular dependencies and compensatory changes. Our review supports further investigation into MEK and JAK/STAT3 inhibition as a novel combinatory therapeutic approach for SHH MB.

Source link: https://doi.org/10.1038/s42003-022-03654-9


Single-cell DNA sequencing identifies risk-associated clonal complexity and evolutionary trajectories in childhood medulloblastoma development.

By single-cell whole-genome sequencing of tumors representing its key molecular sub-classes and clinical risk groups, we reconstructed the natural history and temporal evolution of the most common childhood brain malignancy, medulloblastoma. A single clone with no evidence of evolution was found in most popular risk disease sub-types. In comparison, the most clonally diverse and showed gradual evolutionary drift. These results reveal a variety of pathways of tumor formation and evolution in the major medulloblastoma subclasses, with pathogenic value and clinical promise.

Source link: https://doi.org/10.1007/s00401-022-02464-x


Circular and Fusion RNAs in Medulloblastoma Development.

The cerebellar cancer medulloblastoma is the most common childhood cancer in the brain. RNA sequencing of 81 human biospecimens of medulloblastoma using pipelines was used to identify circular and fusion RNAs. Both the linear and circular fusion fusions were identical, although circular RNAs were generally less prevalent than the circular RNAs. The fusions in medulloblastoma were also similar to cerebellum's, and it was also similar to cerebellum's. A significant number of fusions in tumor can be produced by techniques similar to those that result in fusions in normal tissue.

Source link: https://doi.org/10.3390/cancers14133134


Curcumin analogue BDDD-721 exhibits more potent anticancer effects than curcumin on medulloblastoma by targeting Shh/Gli1 signaling pathway.

Medulloblastoma is a malignant tumor in children's fourth ventricle. Both in vitro and in vivo, a new analysis showed that curcumin attenuated the proliferation of medulloblastoma. We discovered a curcumin analogue named BDDD-721, which had more potent anti-tumor activity than curcumin in the present study. SAG antagonized the pro-apoptotic effects of BD-21 on medulloblastomas as reported by CCK8 assays and flow cytometry, while cyclopamine increased its effects on medulloblastomas. These results, according to our conclusion, suggest that curcumin analogue BDDD-721 has more potent anticancer effects than curcumin on medulloblastomas by targeting the Shh/Gli1 signaling pathway.

Source link: https://doi.org/10.18632/aging.204161


Primary cilia control translation and the cell cycle in medulloblastoma.

For most tumors, the presence or absence of primary cilia is a characteristic of a given tumor type; however, whether and how the primary cilium plays a role in tumor formation is uncertain. Primary cilia are abundant in SHH and WNT MBs, but not so prevalent in G3 and G4 MBs, according to 111 cases of MB. In addition, we extend the role of primary cilia to translation control and unveil a molecular mechanism by which cilia regulate cell cycle progression, giving new frameworks for investigating cilium function in both natural and pathologic conditions.

Source link: https://doi.org/10.1101/gad.349596.122

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions