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Medulloblastoma - DOAJ

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Last Updated: 24 July 2022

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Pediatric Medulloblastoma: Prognostic Value of Preoperative Blood Cell Ratios

In various tumors, the prognostic value of preoperative neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, and platelet to lymphocyte ratio has been shown. Methods and Methods: Forty-three pediatric patients with medulloblastoma were evaluated retrospectively. The Log-rank test was used to determine differences between PFS and OS in the related categories. The PFS and the OS were predicted by the multivariate Cox model, which highlighted the clinical risk group, NLR, and LMR as independent predictors of the PFS and the OS. Patients with NLR 4 and those with LMR u2265 3. 48 were found with OS and PFS, according to the Log-rank test. Based on OS and PFS, there were no differences between patients with PLR > 200 and PLR 200 based on OS and PFS. Our findings show that an elevated preoperative NLR and a reduced preoperative LMR are both able predictors of survival in pediatric medulloblastoma.

Source link: https://doaj.org/article/5bb1dd217f0849bc906f8f60b5e99c66


LC–MS-Based Urine Metabolomics Analysis for the Diagnosis and Monitoring of Medulloblastoma

Medulloblastoma is the most common form of brain cancer in pediatric patients. Body fluid biomarkers will be helpful in diagnostic and therapy. Patients with malignant brain disease, 31 patients with malignant brain cancer, 51 patients with benign brain disease, 29 MB patients, 1 week postsurgery, and 80 MB patients 1 month postsurgery were among the study's 118 healthy controls, 111 MB patients, 31 patients with malignant brain cancer, 31 patients with malignant brain cancer, 51 patients with benign brain disease, 31 patients with malignant brain disease, 51 patients with benign brain disease, 31 patients with traumatic brain tumor metabolomics.

Source link: https://doi.org/10.3389/fonc.2022.949513


TOP2A correlates with poor prognosis and affects radioresistance of medulloblastoma

TOP2A is closely linked to radiation therapy, according to studies. Nuclear DNA topoisomerase II-alpha, a key catalytic enzyme that starts DNA replication, and studies have found that it is closely related to the therapeutic effects of radiation. In this review, we found that TOP2A was significantly upregulated in MB, and that a high incidence of TOP2A contributes to poor MB patient prognosis. In addition, si-TOP2A transfection in combination with irradiation significantly reduced the tumorigenicity of MB cells, compared to those that did not receive si-TOP2A alone. Cell survival curve analysis showed that the survival fraction of MB cells was dramatically reduced following T2A deregulation, and that si-TOP2A-infected cells' decreased D0, Dq, and SF2 values, indicating that TOP2A knockdown reduces the MB cells' resistance to radiotherapy in MB cells. In addition, a western blot review revealed that the operation of the Wnt/u03b2-catenin signaling pathway was impaired after TOP2A downregulation alone or in combination with IR therapy, while overexpression of TOP2A showed the opposite results.

Source link: https://doi.org/10.3389/fonc.2022.918959


Case Report: Primary Leptomeningeal Medulloblastoma in a Child: Clinical Case Report and Literature Review

Medulloblastoma is one of the most common pediatric central nervous system malignancies worldwide, and it is characterized by frequent leptomeningeal metastasizing. We report a rare case of primary leptomeningoma of an 11-year-old Caucasian girl with a long-term disease history, non-specific clinical program, and difficulties in diagnosis diagnosis. MR images of the primary leptomeningeal medulloblastoma are shown by MR images with no changes in the brain and spinal cord, as well as 18FDG-PET/CT photographs showing diffuse heterogeneous hyperfixation of the radiopharmaceutical along the entire spinal cord.

Source link: https://doi.org/10.3389/fped.2022.925340


Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma

Background: Medulloblastoma is the most common childhood brain malignancy. Drug repurposing is a way to expedite anti-cancer therapy with low toxicity. With poor prognosis, we showed the ability of u03b2-blockers to potentiate radiotherapy in medulloblastoma. In medulloblastoma samples from 240 patients, gene expression profiles of u03b2-adrenergic receptors were investigated. The oxygen consumption rate, the extracellular acidification rate, and superoxide production were all determined in Medulloblastoma cell bioenergetics by monitoring the oxygen consumption rate, extracellular acidification rate, and superoxide production. The results: Low quantities of u03b2-blockers significantly enhanced clinically relevant radiation protocols. Although patient biopsies showed positive results for u03b2-adrenergic receptors, the ability of the repurposed drugs to potentiate ionizing radiations did not result from the inhibition of the canonical signaling pathway. These results support the validity of u03b2-blockers as potentiators of radiotherapy in medulloblastoma, which may help with the care and quality of life of children with high-risk brain tumours.

Source link: https://doi.org/10.1016/j.ebiom.2022.104149


Circular and Fusion RNAs in Medulloblastoma Development

Medulloblastoma, the cerebellar cancer medulloblastoma, is the most common childhood cancer in the brain. RNA sequencing of 81 human biospecimens of medulloblastoma using pipelines to find circular and fusion RNAs. In addition, linear and circular fusion RNAs containing exons from various genes were also found at canonical splice sites. The fusion fusions in medulloblastoma were also similar to cerebellum's. Conclusions. A large number of fusions in tumor may be produced by procedures similar to those that cause fusions in normal tissue.

Source link: https://doi.org/10.3390/cancers14133134


mTORC1 promotes malignant large cell/anaplastic histology and is a targetable vulnerability in SHH-TP53 mutant medulloblastoma

a decrease in the p53-dependent expression of mTORC1 negative regulator Tsc2 is largely responsible for the mTORC1 hyperactivation. In vivo, mTORC1 transcription and increased malignancy were both promoted by LC/A features and increased malignancy, and consequently, mTORC1 inhibition in mouse MB cancer stem cells resulted in reduced tumor burden and aggressiveness, as shown by reduced tumor burden and aggressiveness. This subsection of SHH MB may also be a targeted druggable target for this subset of SHH MB, resulting in the introduction of stringent risk stratification and possibly quick translation of this precision medicine strategy into the clinical setting.

Source link: https://doaj.org/article/50c5ba30db8f477f8318eacf4e00e7f0


PTCH1-null induced pluripotent stem cells exclusively differentiate into immature ectodermal cells with large areas of medulloblastoma-like tissue

Abstract Nevoid basal cell carcinoma syndrome is an autosomal dominant condition with an elevated incidence of tumors, such as basal cell carcinomas and medulloblastomas. These gene-edited iPSCs and PTCH1 teratomas were shown to be models for tumor formation, such as medulloblastoma formation and Hh-related tumors in medulloblastoma formation and the suitability of these gene-edited iPSCs and PTCH1 u2212/u2212 teratomas.

Source link: https://doi.org/10.1007/s12672-022-00498-x


New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of Pediatric Medulloblastoma

Pediatric medulloblastoma is the most common pediatric brain tumor with varying prognoses based on the specific molecular subtype. Pediatric patients are particularly vulnerable in ways that adult patients are not. Although the field of research for treating this disease has progressed over the past decade, a deeper understanding is also needed to improve the clinical outcomes for pediatric patients. We'll look at how recent findings into pediatric medulloblastoma have influenced current and future research. The paper includes a brief summary of the healthcare expenses associated with medulloblastoma therapy.

Source link: https://doi.org/10.3390/cancers14092285


Differential prefrontal-like deficit in children after cerebellar astrocytoma and medulloblastoma tumor

Each clinical group was compared to a paired control group in terms of executive functioning in executive functioning. These tests are extremely sensitive to dorsolateral PFC and/or medial frontal cortex functions. The non-verbal Raven IQ's scores were also collected. Using normative results, direct scores were adjusted by age and transformed in standard scores. At 3. 25 years from surgery in CE group and at 6. 47 in the CE+ group, the neuropsychological report was done. The Medulloblastoma organization demonstrated a severe executive deficit in all tested assessments, the most common in vermal patients. executive deficits in digits span, semantic fluency, and a modest to modest deficit in Stroop tests were also shown by the Astrocytoma group. Conclusions: As a result of the findings in astrocytoma group, the results indicate that a differential prefrontal-like deficit as a result of cerebellar lesions and/or cerebellar-frontal diaschisis can be induced and/or exacerbated by medications in the medulloblastoma group.

Source link: https://doi.org/10.1186/1744-9081-4-18

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions