Advanced searches left 3/3

Measurement - ClinicalTrials.gov

Summarized by Plex Scholar
Last Updated: 22 September 2022

* If you want to update the article please login/register

Cervical Stiffness Measurement in Cervical Insufficiency

The aim of this cross-sectional research is to determine the differences in cervical stiffness between patients undergoing cerclage placement and normal pregnancies. The central hypothesis is that women for whom a cerclage is provided would have cervical stiffness measurements lower than normal controls. The current study's completion will spark future research that correlates cervical stiffness pcl in a prospective analysis.

Source link: https://clinicaltrials.gov/ct2/show/NCT04158401


Quantitative Measurement and Correlates of the Latent HIV Reservoir in Virally Suppressed Ugandans

Despite prolonged antiretroviral therapy, HIV-1 can persist as transcriptionally inactive proviruses in resting memory CD4+T cells. When activated CD4+ T cells are infected and revert back to a resting memory state, a latent reservoir can be established. This has resulted in an increase in study into HIV latency in the context of sustained viral suppression with an intention of finding a viable cure regimen that could be used on a large scale. After totally suppressive therapy was stopped, two HIV patients receiving CCR5competent bone marrow transplants had a reemergence of circulating HIV, according to the latest study, a reversible cure for large groups of people remains a elusive goal. However, African populations' strategies to establish a functional cure may differ due to differences in endemic infectious disease load and cellular immune activation, as well as Western populations. This is a longitudinal, descriptive research that seeks to determine the latent HIV reservoir in virally suppressed HIV infected people living in Uganda, as well as the latent reservoir's immunological and virologic correlates of the latent reservoir. The total latent reservoir and its constituent proviral populations will be compared within each individual for changes in the reservoir size and make-up, which may happen over ten years of continuous viral suppression in order to determine the T1/2 or decay rate of the total latent reservoir and its constituent proviral populations.

Source link: https://clinicaltrials.gov/ct2/show/NCT02154035


PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects With Fragile X Syndrome

Several of the physiological and pathological conditions in which changes in regional rates of cerebral protein synthesis occur have been observed in experimental animals with the quantitative autoradiographic L-[1-C]leucine method have found a variety of the physiological and pathological conditions in which changes in cerebral protein synthesis have existed. L-[1-C]leucine PET method The aim of this research is to determine the degree to which changes in rCPS in human subjects can be quantified. Human subjects have been tested with the L-[1-11C]leucine PET technique. In Part I, we'll start L-[1-C]leucine PET analysis in human subjects. We measured rCPS in normal control subjects in two states, awake and under deep sedation/general anesthesia. A difference in rCPs between these two countries may indicate that we can observe activity-dependent protein synthesis using the PET technique. In Part III, we'll look at subjects with fragile X syndrome. The patient group was chosen because the affected gene in fragile X syndrome codes for a protein that is thought to be a negative regulator of message translation, according to this article. A:thony in fragile X syndrome may be due to an effect on protein synthesis that may be very close to the underlying genetic abnormality. The present research establishes the sensitivity of the L-[1-C]leucine PET method to detect changes in rCPS in human subjects. A quantitative and robust way to measure rCPS with PET would increase the tools available for investigating the brain and its regional adaptive responses.

Source link: https://clinicaltrials.gov/ct2/show/NCT00362843


Rest Time Before Blood Pressure Measurement Trial

This research will determine whether BPs obtained immediately or after 2 minutes of rest are non-inferior to the BPs obtained after the guideline suggested 5 minutes of rest. It also wants to determine the time it takes to collect BP from start to finish in order to facilitate the identification of other potential barriers to regular BP screening procedures in crowded academic settings.

Source link: https://clinicaltrials.gov/ct2/show/NCT04031768


Measurement-Based Transition Assistance (MBTA): Evaluating the Promise of a Web-Based Approach to Promote Veterans' Support Seeking

The lack of information, both regarding how difficult it is to warrant help-seeking and what services are available to support these issues, is one factor that stands in the way of Veterans' assistance. Innovation and Impact: Though there has been a lot of hype around the benefits of promoting Veterans' use of mental health services, the investigators are unaware of any broad, measurement-based effort to improve Veterans' ability in multiple areas of unmet need. In addition, most intervention plans are targeted at veterans with chronic impairment and poor health rather than veterans with initial readjustment difficulties as they adjust to post-military life. This intervention will be analyzed among veterans who have recently left military service, given that MBTA can be most helpful to veterans as they transition to post-military life. Aim 1: Based on feedback from veterans and qualitative interviews with Veterans, Aim 1 is to refine MBTA based on VA results and qualitative interviews with veterans. In a pilot RCT, a national sample of Veterans will be randomized to MBTA or an assessment-only condition, based on feedback from VA providers and veterans. Next Steps/Implementation: This pilot study will lead to a new IIR proposal for a fully funded RCT to determine the effectiveness of MBTA and assess measures to promote its dissemination and implementation.

Source link: https://clinicaltrials.gov/ct2/show/NCT05384171

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions