Advanced searches left 3/3

Malignant Transformation - U.S. Department of Veterans Affairs

Summarized by Plex Scholar
Last Updated: 11 February 2022

* If you want to update the article please login/register

Role of the PI3K/Akt pathway in cadmium induced malignant transformation of normal prostate epithelial cells.

This review looked at the role of the PI3K/Akt pathway in the cadmium-induced malignant transformation of normal prostate epithelial cells. Both PWR1E and RWPE1 cells were exposed to ten million Cd for one year and labeled as Cd-PWR1E and Cd-RWPE1. In athymic nude mice, Cd-RWPE1 cells produce tumors with a robust morphology. In comparison to their normal controls, five prostate cancer-related pathways were enriched in Cd-exposed cells. In PCa, an increase in oncogenes and gene downregulation of TS genes was observed as compared to their normal controls. Our analysis shows that the PI3K/Akt signaling pathway involved in the Cd-driven transformation of normal prostate epithelial cells to malignant form. Understanding the cellular pathways involved in Cd-driven malignant transformation of normal prostate cells would provide valuable insight into the development of new therapeutic strategies for Cd-induced prostate cancer.

Source link: https://doi.org/10.1016/j.taap.2020.115308

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions