Advanced searches left 3/3

Malignant Transformation - Europe PMC

Summarized by Plex Scholar
Last Updated: 19 July 2022

* If you want to update the article please login/register

PU.1-dependent enhancer inhibition separates Tet2-deficient hematopoiesis from malignant transformation.

We show that Tet2-deficient mouse hematopoietic stem and progenitor cells undergo malignant transformation as a result of poor gene regulation by heterozygous deletion of upstream regulatory region of the PU. 1 gene. During aging, Tet2 deficient PU. 1 mice are highly penetrant, transplantable acute myeloid leukemia, which is especially relevant with multilineage blood formation at young age. Tet2 and PU. 1 joint suppress leukemogenesis and identified a methylation-dependent gene network as a unifying molecular vulnerability common to AML. Our report shows that Tet2 and PU. 1 work together suppressed leukemogenesis and revealed a methylation-dependent gene network as a unifying molecular vulnerability characteristic associated with AML.

Source link: https://europepmc.org/article/MED/35820129


Loss of RPTPĪ³ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival.

Results reveals that RPTPu03b3 expression declines during human breast carcinogenesis, particularly in high-malignancy grade breast cancer. Low RPTP=u03b3 expression associates with poor prognosis in women with Luminal A or Basal-like breast cancer have poor prognosis. Premalignant changes in macroscopically normal breast tissue, stimulates primary breast cancer formation, promotes malignant breast cancer histopathologies, and reduces recurrence-free survival in mice. Throughout breast carcinogenesis, the expression of Na +,HCO 3 - a breast cancer susceptibility protein- is upregulated in normal breast tissue, but not in wild-type mice. Conclusions Using RPTP increases cellular net acid extrusion and raises NBCn1 expression in breast tissue. These results precede neoplastic manifestations in histopathology, and we suggest that RPTP u3b3-dependent enhancement of Na +,HCO 3 -cotransport primes breast tissue for cancer development as these effects predate neoplastic manifestations.

Source link: https://europepmc.org/article/MED/35821297


Proximal bronchiolar adenoma with malignant transformation to invasive mucinous adenocarcinoma with 4 years follow-up: A case report

bbN adenoma is a rare benign tumor that occurs mainly in lung's periphery. Basal cells in frozen sections are difficult to distinguish by microscopically, making it impossible to tell apart from non-mucinous adenocarcinoma, particularly when malignant transformation of BA into invasive mucinous adenocarcinoma occurs, although histomorphology criteria often contributes to diagnosis. During four years in the outer basal segment of the right lower lobe's upper lobe, the chest computed tomography revealed a high-density nodular gradually increased, followed by thoracoscopic wedge resection of the right lower lobe. Conclusion: In this case, the loss of continuity of the basal cell layer in the area of mucous glandular organs and the driver gene KRAS mutation indicate a malignant change of BA into IMA, so we infer that BA has malignant potential.

Source link: https://europepmc.org/article/PPR/PPR513947


Stanniocalcin 2 drives malignant transformation of human glioblastoma cells by targeting SNAI2 and Matrix Metalloproteinases.

Glioblastoma multiforme is the most malignant brain tumor and is resistant to standard therapies, and it is refractory to medical therapy. GBM cell proliferation and invasive phenotypes can be greatly enhanced by elevated STC2 expression and concealment. Both condition media containing STC2 and recombinant STC2, as well as matrix metalloproteinases, can cause cell morphology change into more malignant phenotypes by upregulating the expression of the epithelial-mesenchymal transition transcription factor, snail family transcription repressor 2 and matrix metalloproteinases. Moreover, we now show that the oncogenic function of STC2 in GBM is mediated by the MAPK signaling pathway.

Source link: https://europepmc.org/article/MED/35790735


Exosomal miR-224-5p from Colorectal Cancer Cells Promotes Malignant Transformation of Human Normal Colon Epithelial Cells by Promoting Cell Proliferation through Downregulation of CMTM4.

CCD 841 CoN, a colour-labeled exosome manufactured in addition to the transfer of exosomes between SW620 and normal colon epithelial cell line CCD 841 CoN. MiR-224-5p can also be moved from SW620 cells to CCD 841 CoN cells by exosomes, in addition. CMTM4 in CCD 841 CoN cells has dramatically decreased the expression of CMTM4 in SW620 cell-derived exosomal miR-224-5p. MiR-224-5p was shown to promote malignant transformation and tumorigenesis in vitro and in vivo by downregulation of CMTM4, which suggests that this miR-224-5p could be a potential target for CRC therapies.

Source link: https://europepmc.org/article/MED/35814269


Exosome-mediated lncRNA SND1-IT1 from gastric cancer cells enhances malignant transformation of gastric mucosa cells via up-regulating SNAIL1.

Background Gastric cancer, as one of the world's most common disorders, is the fourth leading cause of cancer-related deaths. SND1 intronic transcript 1 is highly expressed in exosomes that are not visible by GC cells, and it is particularly prominent in exosomes that are not coding RNA SND1 intronic transcript 1 is highly expressed in exosomes that are not revealed by GC cells. SND1-IT1 was found to bind to microRNA-1245b-5p by competitive adsorption to promote ubiquitin specific protease 3 messenger RNA expression by competitive adsorption. Through USP3, the GE-1 cells undergo malignant transformation of GES-1 cells. Conclusions Exosome-mediated lncRNA SND1-IT1 from GC cells improves ncRNA transformation of GES-1 cells by up-regulating SNAIL1.

Source link: https://europepmc.org/article/MED/35739527


Rapid Malignant Transformation of Adrenal Cortical Adenoma: A Case Report and Review of the Literature

adrenal cortical carcinoma is uncommon and aggressive tumor of the adrenal gland, and it is becoming more apparent with the advancement of science and technology. According to the study, the chance of malignancy in ACC species with benign initial Computed tomography characteristics was 0. 1%. A patient with an AI was admitted to our hospital in 2018. The patient was admitted to our hospital with abdominal pain and neck pain two years after the surgery. A adrenal cortical tumor caused by the pathological diagnosis of liver and retroperitoneal metastatic lesions.

Source link: https://europepmc.org/article/PPR/PPR508838


Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer.

We created single-cell transcriptomes and single-cell transcriptomes from 1,000 to 10,000 cells per sample for 48 polyps, 27 normal tissues, and 6 CRCs gathered from patients with or without germline APC mutations in order to monitor cell composition and cell state changes during the transition from healthy colon to colorectal cancer. A significant number of polyp and CRC cells have a stem-like phenotype, and we've identified a continuum of epigenetic and transcriptional changes in these stem-like cells as they progress from homeostasis to CRC.

Source link: https://europepmc.org/article/MED/35726067

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions