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Malignant Transformation - DOAJ

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Last Updated: 19 July 2022

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Determining the probability of malignant transformation of tobacco-induced oral leukoplakia using tissue p53 as a prognostic marker – A cross-sectional study

Molecular tumor biomarkers such as p53 protein overexpression can help determine the malignant transformation of such potentially malignant oral lesions. Aim: To determine the molecular shifts in oral leukoplakia by investigating tissue p53 expression and correlating it to the clinical and histological findings in order to determine a suitable treatment strategy. Methods and Materials: To determine the percentage positivity of p53 expression, biopsy samples obtained from 25 oral leukoplakia patients were subjected to histopathological and immunohistochemical analysis. By p53% positivity in the cells, Dysplasia grading in IHC sections was estimated by p53% positivity. In the Fisher Exact test, the results showed a statistically significant relationship between histopathological and IHC grading of dysplasia with a P value less than 0. 05. Conclusion: P53 expressions in potentially lethal oral lesions are increasing in tandem with risk of malignancy.

Source link: https://doi.org/10.4103/jiaomr.jiaomr_29_22


Malignant Transformation of Giant Cell Tumor of Bone and the Association with Denosumab Treatment: A Radiology and Pathology Perspective

Primary or secondary occurrences of bone tumor formation are classified as primary or secondary. Using various imaging techniques, we aimed to find specific signs of malignant change in GCTB in this case series from a tertiary referral center sarcoma center. 2 cases were treated with denosumab only, two with denosumab and surgery, two with multiple curettages and radiotherapy, and one with surgical only at the time of mGCTB diagnosis. The mean lag time from diagnosis to malignant change in the 4 denosumab treated patients was 7 months. The absence of fibro-osseous matrix formation and absence of neocortex formation on CT, as well as increased or even increased the soft tissue component are all factors that could be attributed to denosumab therapy's malignant transformation related to denosumab therapy. Secondary mGCTB occurred within the first year after initiating therapy in 4 patients treated with denosumab.

Source link: https://doi.org/10.1155/2022/3425221


Exosomal miR-224-5p from Colorectal Cancer Cells Promotes Malignant Transformation of Human Normal Colon Epithelial Cells by Promoting Cell Proliferation through Downregulation of CMTM4

Carcinogenesis is a result of interactions between malignant cells and neighboring normal cells. In addition, PKH26 dye-labeled exosomes were used to determine the safety of the exosome exchange between SW620 and the normal colon epithelial cell line CCD 841 CoN. MiR-224-5p can be converted from SW620 cells to CCD 841 CoN cells by exosomes, in addition. MiR-224-5p has been shown to promote malignant transformation and tumorigenesis in vitro and in vivo by downregulation of CMTM4, suggesting that miR-224-5p may be a potential target for CRC therapies.

Source link: https://doi.org/10.1155/2022/5983629


Stanniocalcin 2 drives malignant transformation of human glioblastoma cells by targeting SNAI2 and Matrix Metalloproteinases

Abstract Glioblastoma multiforme is the most malignant brain tumor and is resistant to traditional drugs, and is resistant to surgical therapies. We show an association between human glycoprotein stanniocalcin-2 and rapid GBM progression herein, as well as the underlying mechanism. GBM cell growth and invasive phenotypes can be greatly enhanced by elevated STC2 expression and concealment. Moreover, we now show that the oncogenic function of STC2 in GBM is mediated by the MAPK signaling pathway. These findings, taken together, reveal the mechanism by which STC2 attacks SNAI2 and MMPs in GBM's MAPK pathway, as well as provide insight into the development of a potential therapeutic strategy for GBM.

Source link: https://doi.org/10.1038/s41420-022-01090-6


Malignant Transformation of Grade II Ependymoma in a 2-Year-Old Child: Case Report

Abstract Ependymomas are central nervous system neoplasms responsible for a third of all posterior fossa tumors in children. In a 2-year-old boy with vomiting and visual disturbance, we have a case report of a misdirected transformation of an infratentorial grade II ependymoma. Anaplastic pendymoma transformation to grade III is possible for a grade II pendymoma, but it is extremely uncommon. Infants have a shorter prognosis than older children, so we need individual clinical evaluation and close follow-up in such situations.

Source link: https://doi.org/10.1055/s-0035-1549311


Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study

Methods: An institution's retrospective review of 1179 cases mature teratoma from August 1999 to December 2019 was done. The chief reasons of the pathological phenotypes and clinical manifestations of mature teratoma with malignant transformation were discussed in 14 cases of mature teratoma with malignant transformation. Pathological findings reveal that there were 5 cases of squamous cell carcinoma, 3 cases of carcinoid, 2 cases of serous carcinoma, and 2 cases of thyroid papillary carcinoma, 1 case of strumal carcinoid. Both cases of squamous cell carcinoma had pelvic and abdominal metastasis. In mucinous glands around carcinoid, EMA and CK20 were positive. In the mesenchyme adjacent to the intestinal mucinous gland, Calretinininin and inhibin were positive. Conclusions: Teratoma with malignant growth is a rare disease, but teratoma is a common germ cell tumor. Squamous cell carcinoma is the most common type of carcinoma and is prone to metastasis.

Source link: https://doi.org/10.4103/IJPM.IJPM_828_20


30-Year Experience With 22 Cases of Malignant Transformation Arising From Ovarian Mature Cystic Teratoma: A Rare Disease

paraphrasedoutput:MethodsFrom 1988 to 2020, this retrospective study included patients with ovarian mature cystic teratoma. The aim was to determine the clinical characteristics and survival outcomes of patients with ovarian MCTs at Peking Union Medical College Hospital. The MT-MCT patients and 22 patients with MT-MCT were enrolled when the pathologic histology was determined. ResultsOverall, 7229 ovarian MCT patients and 22 patients with MT-MCT were enrolled when the pathologic histology was MT-MCT. All ovarian MCTs had a malignant transformation rate of 0. 3 percent. The majority of patients with MT-MCT were 51 years old, and the tumor mass size was 10 cm. Squamous cell carcinoma was the first known histological disorder to suffer malignant change, followed by adenocarcinoma, carcinoid, and borderline tumors were the most common histologic disease type to undergo malignant transformation. Patients with FIGO stage I and II had the highest RFS and OS, followed by those with FIGO stage II-IV. Conclusion MT-MCTs are mostly present in elderly females, with poor prognosis and are present in elderly females. Women with MCT should have surgical intervention for Perimenopausal and Menopausal women with MCT.

Source link: https://doi.org/10.3389/fonc.2022.842703


Malignant Transformation of Recurrent Residual Cerebellopontine Angle Epidermoid Tumor: Significance of Clinical Vigilance and Long-term Surveillance

Epidermoid tumors are slow-growing tumors in which malignant transformations occur extremely rarely. The rapid-onset, progression, and recurrence of symptoms are all Malignant transformation warning signs. Here we have a case report of a 68-year-old woman with a long history of left-sided cerebellopontine angle ET who died with a recent onset of symptoms and the MRI study of new ET contrast enhancements.

Source link: https://doi.org/10.1055/a-1858-7483


Atypical Endometrial Hyperplasia Arising in a Cesarean Section Scar: A Mechanism of Malignant Transformation

The incidence of scar endometriosis in Cesarean sections varies between 0. 03 and 0. 4 percent. This paper presents anatomopathologic evidence of an early-stage malignant change in endometriotic tissue from a post-Cesarean scar, as well as briefly discussing potential root causes. A 40-year-old woman with a body mass index of 42. 7 was referred to the gynecological department for persistent pain and the presence of a palpable mass in her Cesarean section scar. Endometriotic foci inoculated within an abdominal scar can undergo persistent changes. The physician needs special care in the case of long-lived abdominal scar endometriosis in morbidly obese women.

Source link: https://doi.org/10.1159/000499760


SARS-CoV-2 M Protein Facilitates Malignant Transformation of Breast Cancer Cells

However, there are also few studies on the effects of SARS-CoV-2 infection on breast cancer progression, as well as the causes and mechanisms involved. We investigated the effects of SARS-CoV-2 proteins on breast cancer cells in the current study. In addition, the hormone-dependent breast cancer cell line MCF-7 had less reaction to M protein in comparison to MDA-MB-231 cells, with the protein lacking no evidence of proliferation, stemness, or in vivo metastasis. Therefore, SARS-CoV-2 infection can cause aggressive BCC to produce the non-aggressive BCC's malignant phenotypes. In addition, the inhibition of NFu03baB and STAT3 signaling pathways is regarded as a promising candidate for the treatment of TNBC patients with COVID-19, which is also a promising treatment.

Source link: https://doi.org/10.3389/fonc.2022.923467

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions