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Malignant Mesothelioma - Springer Nature

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Last Updated: 23 November 2022

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SMG6 regulates DNA damage and cell survival in Hippo pathway kinase LATS2-inactivated malignant mesothelioma

Many genes responsible for Malignant mesothelioma have been identified as tumor suppressor genes, but it's difficult to target these genes specifically at a molecular level. We looked for a gene that displayed synthetic lethal phenotype with LATS2, one of the MM causal genes and one of the Hippo pathway's kinases. In vivo, we reported the inhibitory effects of LATS2 and SMG6 on cell proliferation. SMG6 and TERT, according to We also suggest that SMG6 and TERT be novel molecular target candidates for LATS-inactivated cancers such as MM.

Source link: https://doi.org/10.1038/s41420-022-01232-w


RhoA and vigilin are candidates for immunohistochemical markers for epithelioid malignant mesothelioma

Diagnostic tools of malignant mesothelioma have been extensively researched. The majority of epithelioid MM patients were positive for both RhoA and vigilin, however, both IHCs had lower stainability in biphasic and sarcomatoid MM. In addition, both IHCs had significantly higher stainability for RhoA and vigilin in epithelioid MM than in LAC and LSC. In epithelioid MM, a H-score test revealed that there was no significant difference between RhoA and calretinin and vigilin versus calretinin in IHC positivity. In conclusion, RhoA and vigilin may be suitable for immunohistochemical markers for epithelioid MM.

Source link: https://doi.org/10.1038/s41598-022-20334-0

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions