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Malaria - BioRxiv

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Last Updated: 15 July 2022

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Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle

In several eukaryotes, microtubule-based motors such as Kinesins are microtubule-based motors important in cell division, motility, polarity, and intracellular transport. Only kinesin-13 is required for growth in the mammalian host, according to the monkey, although the other eight kinesins are required during the proliferative and invasive stages of parasite transmission by the mosquito vector. In-depth investigations of kinesin-13 and kinesin-20 revealed roles in microtubule dynamics during apical cell polarization formation, spindle assembly, and axoneme biogenesis. These results help us to recognize the importance of microtubule motors and may be exploited to discover new therapeutic approaches against malaria.

Source link: https://doi.org/10.1101/2021.05.26.445751


A toolbox of engineered mosquito lines to study salivary gland biology and malaria transmission

We have created fluorescent reporter lines in Anopheles coluzzii's African malaria mosquito Anopheline dehydrated plaquelet protein, the triple functional domain protein, and saglin. To determine the effectiveness of in vivo microscopy of parasitized salivary glands, we combined the aapp-DsRed fluorescent reporter line with a pigmentation-deficient yellow mosquito mutant. Plasmodium sporozoites' salivary gland was discovered by a combination of cuticle and imaging of individual sporozoites in vivo, which facilitates live imaging studies of salivary gland colonization by Plasmodium sporozoites.

Source link: https://doi.org/10.1101/2021.08.16.456529

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions