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Major Depressive Disorder - DOAJ

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Last Updated: 21 July 2022

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Suffering Depression: Illness Perception of Informal Primary Caregivers of Medical Students With Major Depressive Disorder

When a family member has depression at a point that causes disability in various occupational domains, the informal primary caregiver is the individual with the majority of the patient's emotional and basic needs. This phenomenological qualitative research sought to investigate the disease presence in IPCs of undergraduate medical students previously diagnosed with mild depression. For mental health professionals, it is imperative to have a more complete clinical view by understanding the illness perceptions not only of patients but also of family IPCs.

Source link: https://doi.org/10.1177/2374373520958514


Automated Detection of Major Depressive Disorder With EEG Signals: A Time Series Classification Using Deep Learning

This report focuses on the automated detection of MDD using EEG results and deep neural network architecture. Through 19-channel raw EEG signals, a customized InceptionTime model is introduced to first detect MDD people first. Only the first minute of EEG recording is sufficient for MDD detection, according to our study, ii models based on EEG data in eyes-closed resting-state outperform eyes-open conditions, and iii customizing the InceptionTime model can increase its effectiveness for different projects.

Source link: https://doi.org/10.1109/ACCESS.2022.3190502


Aberrant Dynamic Functional Connectivity of Posterior Cingulate Cortex Subregions in Major Depressive Disorder With Suicidal Ideation

Accumulating evidence reveals the presence of structural and functional abnormalities of the posterior cingulate cortex in patients with a significant depressive disorder and suicidal ideation. The left dPCC and left fusiform gyrus, as well as the left dPCC and left fusiform gyrus, as well as the left vPCC and left fusiform gyrus, and the left vPCC and left fusiform gyrus, as well as the left dPCC and left fusiform gyrus, as well as the left vPCC and left frontal vPCC and left vPCC and left fusiform gyrus, as well as gyrus and left fusiform gyrus and left fusiform gyrus and left gyrus and left gyrus and left fusiform gyrus and left gyrus and left fusiform gyrus and left fusiform gyrus gyrus, as the vPCC and left gyrus gyrus, as the right gyrus and left gyrus and left The left vs. PCC and left IFG showed greater dFC variability within the SI group than the NSI group. In addition, the dFC difference between the left vs. PCC and the left IFG was positively related to Scale for Suicidal Ideation score in patients with MDD. Our results show that persistent dFC variability between the vPCC and IFG may be an important source of future therapeutic intervention in MDD patients with SI.

Source link: https://doi.org/10.3389/fnins.2022.937145


Early Effects of Repetitive Transcranial Magnetic Stimulation Combined With Sertraline in Adolescents With First-Episode Major Depressive Disorder

paraphrasedoutput:MethodsThe aim of the study was to investigate the early effects of repetitive transcranial magnetic stimulation in combination with sertraline in adolescents with first-episode major depressive disorder. Attention Quantitative Attention This was higher than those in the control group after therapy, and the differences were statistically significant. First-onset adolescent depression was shown in Spotter at a higher rate in Spotter than the control group after treatment, according to the study group. Discussion of the study This is the most comprehensive, randomized clinical study to date looking at the benefits of 10-Hz add-on rTMS for first-onset adolescent depression.

Source link: https://doi.org/10.3389/fpsyt.2022.853961


Alterations of Plasma Lipids in Adult Women With Major Depressive Disorder and Bipolar Depression

However, the composition and comparison of the peripheral lipids pertaining to adult women with major depressive disorder or bipolar depression have been patched out. In addition, we established diagnostic potential biomarkers that can distinguish BPD from HC and 8 lipids that can distinguish BPD from HC, as well as 13 lipids that can distinguish MDD from BPD with moderate fidelity. This research provides additional insight into abnormal lipid metabolism in adult women with MDD and BPD, as well as the ability to distinguish MDD from BPD and HC.

Source link: https://doi.org/10.3389/fpsyt.2022.927817


Distinct proteomic profiles in prefrontal subareas of elderly major depressive disorder and bipolar disorder patients

Abstract: For the first time, proteomic results were published both in the dorsolateral prefrontal cortex and anterior cingulate cortex of patients with significant depressive disorder and bipolar disorder patients. The precise quantification of over 3000 proteins was accurately measured, with more than 100 protein expressions reporting as significant differences in these two brain areas of MDD and BD patients as compared to their respective controls. U2018suppressed energy metabolism in MDD's DLPFC was the most notable change we saw in the DLPFC of MDD, according to the ACC of MDD, where it was mainly brain-oriented and reduced immune response; in the DLPFC of BD, it was distinguished as a u2018suppressed tissue remodeling and reduced neuronal projection and reduced neuronal projection;u2019. In summary, there are specific proteomic shifts in multiple brain regions of the same mood disorder's mental health condition, as well as in the same brain area between MDD and BD patients, which increases the distinct pathogenes and therefore treatment targets.

Source link: https://doi.org/10.1038/s41398-022-02040-7


The role of leptin in indirectly mediating “somatic anxiety” symptoms in major depressive disorder

Results We discovered that leptin was elevated in MDD patients' clinical status and symptomatic dimensionalities of MDD using mediation analysis, but we only predicted u201csomatic anxietyu201d symptoms. Conclusions Conclusion Leptin's study revealed that it was a significant and indirect mediator of clinical risk and u201csomatic anxiety u201d symptoms.

Source link: https://doi.org/10.3389/fpsyt.2022.757958


Identification of Sex-Specific Plasma Biomarkers Using Metabolomics for Major Depressive Disorder in Children and Adolescents

BackgroundChildren and adolescents are at a high risk of major depressive disorder with known sex differences in epidemiology, which is also linked to gender disparities in epidemiology. paraphrasedoutput:MethodsHere, a male series of 42 cases and 27 healthy controls with MDD, was among the few commercial laboratory-based sex-specific biomarkers available to aid in the diagnosis of male and female patients with MDD. MethodsHere, a male group of 42 cases and 27 healthy controls, as well as a female group of 42 cases and 22 HCs were recruited. The results of this research investigated the sex differences of plasma metabolite biomarkers in young patients with MDD using ultra-high-performance liquid chromatography system that used quadrupole time-of-flight mass spectrometry demonstrated distinct differences in both male and female groups. Both male and female MDD patients with HC differed pathways in comparison with HCs.

Source link: https://doi.org/10.3389/fpsyt.2022.929207


Correlation Between Serum High-Sensitivity C-Reactive Protein, Tumor Necrosis Factor-Alpha, Serum Interleukin-6 and White Matter Integrity Before and After the Treatment of Drug-Naïve Patients With Major Depressive Disorder

BackgroundPrevious studies have reported that systemic inflammation can destroy white matter's integrity. However, how the cytokine levels in serum cytokine influence white matter in major depressive disorder patients is uncertain. paraphrasedoutput:MethodIn total, 29 MDD patients and 25 healthy controls were included in this study, with the intent of investigating the correlation between inflammatory cytokine levels and white matter microstructure in drug-nau00efve patients with MDD pre- and post-treatment. Method All subjects at baseline were assessed, and the MDD patients were reassessed after venlafaxine therapy, using a tract-based spatial statistics review. ConclusionThe FA values of the left IC-PL was significantly linked to the peripheral hs-CRP levels in both pre- and post-treatment MDD patients, according to the poster hs-CRP values. The left IC-PL's FA value was inversely related to both pre- and post-treatment MDD patients, according to the study.

Source link: https://doi.org/10.3389/fnins.2022.948637


Omega-3 Polyunsaturated Fatty Acids Supplementation Alleviate Anxiety Rather Than Depressive Symptoms Among First-Diagnosed, Drug-Naïve Major Depressive Disorder Patients: A Randomized Clinical Trial

ResultsBoth groups reported an increase in clinical characteristics at week 4 and week 12 compared to baseline, with Hamilton's anxiety scale, Beck depression scale, Beck depression scale, and self-rating anxiety scale. At week 4, the rate of anxious responses in the n-3 PUFAs group was significantly higher than in the placebo group, although week 12 did not make a difference. No significant difference between the two groups was found between the two groups in terms of response rates for depression at both week 4 and week 12. ConclusionThe anxiety symptoms were more frequent than depressive signs at the early stage of therapy for first-diagnosed, drug-nau00efve depressed patients, rather than depressed patients.

Source link: https://doi.org/10.3389/fnut.2022.876152

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions