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The mortality of patients with early brainstem hemorrhage is high, according to clinical studies. We created rat models of brainstem hemorrhage by injecting type VII collagenase into the right basotegmental pontine and investigating the pathological changes of early brainstem hemorrhage using multi-sequence magnetic resonance imaging and histopathological techniques in this study. Brainstem hematoma gradually developed in the injured rats over the first three days and then decreased after 7 days.
Source link: https://europepmc.org/article/MED/35799538
Pre-treatment bpMRI and Grade group 1 are both listed as predictors of prostate cancer augmentation in men with Grade group 1 and pre-treatment bpMRI. Methods and methods This single-center research included men with GG1 cancer on prediagnostic biopsy who underwent bpMRI and robotic-assisted radical prostatectomy between March 2014 and September 2019. To find predictors of upgrading, we estimated logistic regression models. The likelihood of upgrading was lower for men with a PIRADS 1-3 than for PIRADS 4-5, but the difference was not statistically significant. With increasing PSA density, the risk of men with PI-RADS 1-3 increased. Conclusions The PSA density is a clinically important determinant in predicting change from GG1 to PI-RADS 1-3, when bpMRI finds PI-RADS 1-3. Regardless of the PSA density, the likelihood of undetected GG 2-5 cancer in men with a PI-RADS 4-5 on bpMRI is high in men with a bpMRI.
Source link: https://europepmc.org/article/MED/35591966
Brain radiomics can reveal brain pathophysiology's specifics. We collected high-resolution T1-weighted images, R2* mapping, and quantitative susceptibility testing results from 171 patients with PD and 179 healthy controls recruited from August 2014 to August 2019, in this prospective effort to develop a model for PD diagnosis based on brain imaging findings. We extracted 1408 radiomics results and then used data-driven feature selection to highlight informative characteristics that were useful for distinguishing patients with PD from normal controls on the training database. In conclusion, the multiple-tissue-specific brain radiomics model constructed from magnetic resonance imaging has the ability to discriminate PD and demonstrates the advantages of enhancing PD diagnosis.
Source link: https://europepmc.org/article/MED/35662223
Gastric cancer is a common disease with elevated morbidity and mortality rates around the world. According to in vitro experiments, the PP@Mn NPs cause ferroptosis in cancer cells by releasing abundant reactive oxygen species via a Fenton-like reaction mixed with PTT. In addition, in vitro studies showed that the PP@Mn NPs, as well as the PTT at the tumor site, have CDT anti-tumor activity. In conclusion, the PP@Mn NPs could be an effective tool for CDT/PTT synergistic ferroptosis therapy for GC.
Source link: https://europepmc.org/article/MED/35403518
Objective Periventricular nodular heterotopia is a neurological disorder in which neurons fail to migrate to the cortical surface, resulting in isolated areas of grey matter adjacent to the lateral ventricles. Given that periventricular nodular heterotopia is seen as unusual occurrence in patients without epilepsy, no causal link between periventricular nodular heterotopia and epilepsy cannot be determined. In addition, the clinical features of periventricular nodular heterotopia in patients with epilepsy are also poorly defined and can be misleading. Methods Pediatric patients with periventricular nodular heterotopia were identified and divided into two groups: with epilepsy and without epilepsy. Significance Most radiological features of periventricular nodular heterotopia are similar in patients with and without epilepsy. Periventricular nodular heterotopia necessitates extensive investigation and should be interpreted within each individual patient's context, rather than being merely causative of epilepsy nor unrelated to it.
Source link: https://europepmc.org/article/MED/35792848
The intention of this research was to develop a method that quantifies WSS from two-dimensional phase contrast magnetic resonance imaging derived waveforms, apply this technique to PCMR data obtained in healthy volunteers' abdominal aorta, and compare PCMR-derived WSS values to those predicted from a computational fluid dynamics simulation. The method uses PCMR-derived flow versus time waveforms constrained by the Womersley design for pulsatile flow in a cylindrical tube. In the aortas of healthy men and women, a time-averaged WSS was compared, and time-averaged WSS was obtained. When comparing TAWSS between CFD and the PCMR-based technique with a correlation coefficient of 0. 88, a comparison of WSS values between the PCMR-based method and CFD forecasts shows that the PCMR method underestimated instantaneous WSS by 3. 8 dyn/cm2 according to a correlation coefficient of 0. 88, though comparison of WSS values between the PCMR-based method and CFD forecasts indicates that the PCMR-based method underestimated 2. 6 0. 6 et.
Source link: https://europepmc.org/article/MED/35377416
As an alternative to traditional autopsy in the prenatal and postnatal periods, post-mortem imaging has been suggested as an alternative to autopsy. We conducted a prospective, multicentre, cross-sectional study to compare the diagnostic results of post-mortem magnetic resonance imaging with computed tomography-guided biopsy in foetuses and infants with conventional autopsy. Computed tissue sampling was performed after post-mortem imaging using a computed tomography scanner and a magnetic resonance imaging unit. Secondary findings included the number of false positive and false negative major pathological lesions detected by virtopsy, as well as the proportion of computed tomography-guided biopsies that were appropriate for histological examination. In 561 of 956 biopsies, computed tomography-guided tissue sampling was sufficient for pathological findings and added valuable diagnostic value in five of the 30 cases of unknown cause of death before autopsy, compared to postmortem imaging alone. In all fetal cases, placental examination revealed the infection.
Source link: https://europepmc.org/article/MED/35918685
However, the number of ovarian tumors encountered in daily life is somewhat constant, with the exclusion of rare ovarian tumors. Magnetic resonance imaging is used for determining ovarian tumors, according to the article. Endometriosis, benign cystadenomia, functional cysts, surface epithelial inclusion cysts, thermotubular cysts, and endometriosis are all typical lesions associated with cytometric cystadenoma, vitronectic cysts, endometriosis. Mucinous tumors and ovarian metastases are among the second two, multilocular cystic ovarian lesions. Even if no solid component is present, it should be noted that mucinous tumors can be classified as borderline or carcinoma. There are third, cystic lesions with mural nodules that are unrelated to endometriosis, including serous borderline tumor and serous carcinoma. Seromucinous borderline tumors, endometriosis, and apparent cell carcinoma are among the common endometriosis tumors derived from endometriosis in the fourth quarter. In mature cystic teratoma, mural nodules are often visible, but they do not indicate malignancy.
Source link: https://europepmc.org/article/MED/35916971
In patients with acute left ventricular dysfunction in the acute phase of illness or persistent LV dysfunction, the American College of Rheumatology Clinical Guidelines recommends cardiac magnetic resonance imaging 2-6 months after the diagnosis of MIS-C in patients with significant transient left ventricular dysfunction. In MIS-C patients, there are a few studies examining cardiac MRI findings. During follow-up, echocardiography revealed normal LV systolic function in all patients; during follow-up, coronary dilatation persisted in 2 of 5 patients at the 6th-month visit. Even if echocardiography does not reveal any abnormalities in the first phase, cardiac MRI should be performed in MIS-C patients in the late period. This is the first study to announce cardiac MRI findings in the late period of MIS-C patients.
Source link: https://europepmc.org/article/MED/35916926
On regular shoulder magnetic resonance imaging, Cystic lesions of the humeral head are common. For example, cysts of the bare area of the humeral head are considered benign age-related entities, while cysts of the greater or lesser tuberosity may herald rotator cuff disease. Postoperative lesions related to the use of suture anchors in surgical procedures such as rotator cuff tear repairs are common among Perianchor cysts. Knowing the chemistry of various cystic lesions in the humeral head and the underlying aetiology can be helpful in assisting the radiologist in establishing a more detailed search pattern for related disorders. Determining the root of cysts can have significant effects on management, particularly when distinguishing perianchor cysts from infection. This pictorial review discusses MRI findings that show the varying diagnoses of humeral head cysts and provides a diagnostic approach for the radiationologist.
Source link: https://europepmc.org/article/MED/35919060
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