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Cerebral small vessel disease accounts for 20% of ischemic strokes and is the most common cause of cardiovascular cognitive impairment. Magnetic resonance imaging studies is able to detect changes in white matter structure and subtle vascular function transitions, which are related to cognition deficits in cSVD. The MRI findings may also serve as a useful surrogate marker.
Source link: https://clinicaltrials.gov/ct2/show/NCT05200377
Compare the repeatability of DW-MRI procedures in lesions and healthy tissue by estimating the squared difference between each pair of repeated ADC measurements in lesions and healthy tissue, and we will use the DW-MRI method as a covariate using Generalized Estimating Equations to display this value. Optimized muscle measurement by three radiologists using a Likert scale: Optimization in healthy volunteers Optimized bh, M1 and M2 parameters by minimization of error and bias in ADC estimation across the liver Optimized motion-corrected averaging by three radiologists using a Likert scale. The cross-corcorrelation coefficient will be used to determine alignment between each of the DW-MRI datasets and the reference T2-weighted acquisition in order to determine image distortions in DW-MRI. Three radiologists will assess each DW-MRI reconstruction using a Likert scale between 0 and 4 for several variables: motion artifacts, spatial resolution, distortions, apparent SNR, and overall image quality. Each reader will repeating ADC measurements after two months will determine intra-reader variability. Demonstrate excellent image quality and precise quantitative diffusion parameter mapping using the latest DW-MRI technologies in a representative and clinically relevant field for the diagnosis of liver metastases by assessing in patients: 3a. Novel vs. traditional DW-MRI techniques determines the precision of ADC measurements in the liver by novel vs. standard DW-MRI techniques.
Source link: https://clinicaltrials.gov/ct2/show/NCT05261633
Amyotrophic lateral sclerosis is a disabling and fast-progressing neurodegenerative disorder. New biomarkers in MRI at three levels: cerebral, medullary, and muscular. MRI will be performed on ALS patients at baseline, at 3 month, and at 6 month intervals.
Source link: https://clinicaltrials.gov/ct2/show/NCT04691011
This research is being done to see changes in muscle imaging over time in people with facioscapulohumeral muscular dystrophy. This research is being carried out to see how muscle strength and function change as a result of muscle mass and function. The investigators intend to use MRI and MRS data to develop outcome measures that can be used in future clinical trials for FSHD.
Source link: https://clinicaltrials.gov/ct2/show/NCT01671865
More than 600 participants in ASD were recruited since 2010 to help determine the effects of brain abnormalities in ASD. The aim of the study, according to the researchers, was to identify the presence of brain abnormalities in ASD. The goal of this research, which includes genetic and clinical consistency of the collected results.
Source link: https://clinicaltrials.gov/ct2/show/NCT05470088
The retina and optic nerve components of the study have been omitted with amendment F, and we've expanded our scope to include participants with multiple sclerosis and MRI findings of abnormal permeability to gadolinium. Mangafodipir, which remains in the extracellular space, can be used to assess brain connectivity in these individuals. Population study Results Up to 15 healthy volunteers and up to 15 people with multiple sclerosis, as well as up to 15 people with multiple sclerosis. Participants with multiple sclerosis are included in the second phase of studies. With amendment F, the emphasis has shifted to evaluating participants with multiple sclerosis and evidence of gadolinium enhancement on contrast-enhanced brain MRI. Outcome Measures Following the administration of mangafodipir and T1-weighted signal intensity in the retina, optic nerve, and brain at three time points after administration; and in the basal ganglia, cerebral cortex, and whole brain are among the primary outcome measures.
Source link: https://clinicaltrials.gov/ct2/show/NCT01326715
Heart catheterization is a minimally invasive procedure used to measure heart pressure in specific heart cavities. Heart catheterization is mainly X-ray advice, which involves radiation exposure and does not always show soft tissue. For many years, real-time magnetic resonance imaging fluoroscopy has been the most common method to guide right heart catheterization at the NIH clinical center. Guidewires are common devices used to guide catheters through the body and heart. In this protocol, we will use guidewires during otherwise standard MRI catheterization of the right side of the heart through veins and the left side of the heart through the aorta. We'll begin performing systematic MRI guidewire heart catheterization without X-ray implantation in the second phase of the protocol. During MRI catheterization tailored to the patient's situation, we will evaluate the heart's reaction to hemodynamic provocation.
Source link: https://clinicaltrials.gov/ct2/show/NCT03152773
When researchers first electroencephalographic sleep studies, a strong correlation was found between electroencephalographic slow waves and auditory thresholds, Electroencephalography became a surrogate for the behavioral model. We hypothesize that unconscious patterns of brain movement or functional connectivity exist during sleep, and that a sleep-based approach could reveal these patterns. Study Results The subject group in this survey will be young, healthy people with high sleep quality. Design After a one-week home-monitoring period that includes a regular in-to-bed and out-of-bed sleep testing, the participants will go through two all-night functional magnetic resonance imaging sleep studies separated by a one-week washout period with continued home monitoring. We will quantify sleep depth by stimulating subjects with auditory stimuli that gradually increase in intensity. Generated The information collected will be auditory arousal thresholds and the preceding brain function and functional connectivity from functional magnetic resonance imaging.
Source link: https://clinicaltrials.gov/ct2/show/NCT02629107
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