Advanced searches left 3/3

Msh - DOAJ

Summarized by Plex Scholar
Last Updated: 27 December 2022

* If you want to update the article please login/register

Jeju Magma-Seawater Inhibits α-MSH-Induced Melanogenesis via CaMKKβ-AMPK Signaling Pathways in B16F10 Melanoma Cells

Melanin shields the skin from ultraviolet radiation, lethal drugs, and chemicals. In addition, melanogenesis disorders are also linked to neurodegenerative diseases. B16F10 melanogenesis cells: We report novel inhibitory effects of Jeju magma-seawater on melanogenesis caused by the hormone u03b1-melanocyte stimulating hormone in B16F10 melanoma cells in the present study. The abundant underground seawater discovered in Jeju Island, a volcanic island of Korea, is the abundant underground seawater. However, no information is available regarding JMS' effect on melanogenesis. Our findings reveal that JMS could be a novel therapeutic agent for treating skin pigmentation-related disorders.

Source link: https://doi.org/10.3390/md18090473


Association between Ag-RP, alpha-MSH and cardiovascular risk factors regarding adherence to diet quality index-international (DQI-I) among obese individuals

In the current study, we investigated the relationship between u03b1-MSH and Ag-RP with cardiometabolic risk among obese people with different adherence to Diet Quality Index-International guidelines. Participants in the Dietary intakes and DQI-I estimate were assessed using a semi-quantitative food frequency survey with 132 food items. The Homeostasis model's assessment of insulin resistance index and quantitative insulin sensitivity check index was also estimated, as well as the determination of a quantitative insulin sensitivity test index. Ag-RP was positively associated with systolic blood pressure among males, which was also linked to waist circumference and diastolic blood pressure, among those with the lowest adherence to DQI-I. Also, Ag-RP showed a positive correlation with BMI values. Conclusion: According to our findings, obese patients with poor to moderate adherence to DQI-I, Ag-RP, and u03b1-MSH were in positive correlation with cardiometabolic risk factors.

Source link: https://doi.org/10.34172/jcvtr.2021.48


Characterization of Magnesium Silicate Hydrate (MSH) Gel Formed by Reacting MgO and Silica Fume

Magnesium silicate hydrate gel was created by reacting magnesium oxide with silica fume in distilled water. MSH gel's structure was characterized by solid state nuclear magnetic resonance and Fourier transform infrared spectroscopy. The MSH gel is highly disordered and arises on the surface of particles, resulting in a shell structure with cavity, unlike natural magnesium silicate hydrate minerals. The extent of polymerization of MSH gel is also related to the solution pH during hydration, according to the results.

Source link: https://doi.org/10.3390/ma11060909


Neuropeptide Y and α-MSH circadian levels in two populations with low body weight: anorexia nervosa and constitutional thinness.

Anorexia nervosa has a dynamic appetite regulating profile, with elevated ghrelin and 26RFa, as well as low levels of leptin and PYY. Plasma u03b1-MSH levels were noticeably lower in AN all over the day. In the case of anorectic women's inability to adapt food intake to their energy needs, the CT group achieved lower levels of u03b1-MSH in the morning and evening, as well as a significant rise during lunchtime. In CT women, the u03b1-MSH peak observed during lunchtime could explain why these patients are so satisfied with fast food satisfaction.

Source link: https://doi.org/10.1371/journal.pone.0122040


Anti-melanogenesis effect from Wampee fruit pectin via α-MSH/TRY pathway in A375 cells

Pectin extract from wampee fruit in A375 cells was tested for physicochemical properties and the anti-melanogenesis effect. Methods The physicochemical analysis of pectin from wampee fruit was investigated by gel chromatography, FT-IR spectroscopy, and NMR spectroscopy techniques. In vitro, the anti-melanogenesis effects and mechanism were investigated by mushroom tyrosine enzyme and human melanin cell model. According to the current report, WFP can significantly reduce mushroom TRY activity in vitro. WFP reduced intracellular and extracellular melanin formation in A375 melanoma cells, according to the presence of alpha-melanocyte stimulating hormone u03b1-MSH. In u03b1-MSH-treated A375 cells, TRY activity was only limited. In A375 melanoma cells, including in down-regulated TRY, TYRP-1, TYRP-2, MITF, and CREB expressions, WFP reversed u03b1-MSH-induced melanogenesis, according to a Western blot review, which revealed that CREB did not induce melanogenesis, including in down-regulated TRY, TYRP-1, TYRP-2, MITF, and CREB FE MITF, mela cells, regulated TRY, regulated TRY, TYRP-1, TYRP-2, MITF and MITF and CREB FE, TYR-1-MSH-In fibro induced melanot-F and RI MITF and Embema-In Embe Embet regulated TRY, induced Emberobe TYRP-1-IM, TYRP-1-BA-IN TYRP-1, TYRP-2, IF, FI, Embet-B1- WFP was shown to delay u03b1-MSH-induced melanogenesis in A375 melanoma cells by the u03b1-MSH/TRY pathway, according to the u03b1-MSH/TRY pathway.

Source link: https://doi.org/10.1186/s12906-022-03646-6


[6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3K/Akt-Mediated MITF Degradation

The purpose of the investigation was to identify the potential skin whitening properties of [6]-shogaol. The effects of [6]-shogaol's cell viability, melanin content, tyrosinase production, and the expression of the tyrosinase and microphthalmia-associated transcription factor were determined. [6]-shogaol reduced the protein expression levels of tyrosinase-related protein 1 and microphthalmia-associated transcriptional factor, among other things. The degradation of MITF [6]-melanocyte stimulating hormone-induced melanogenesis was also influenced by increased extracellular responsive kinase and phosphatidylitol-3-kinase in our confocal assay results, according to our confocal assay data.

Source link: https://doi.org/10.1155/2014/842569


α-MSH Influences the Excitability of Feeding-Related Neurons in the Hypothalamus and Dorsal Vagal Complex of Rats

Extracellular neuronal activity was found in the hypothalamus and the dorsal vagal complex of anesthetized rats in the present study, which may help clarify the mechanisms by which u03b1-MSH exerts its anorectic functions. We investigated the effects of u03b1-MSH on glucose-sensing neurons and gastric distension sensitive neurons. u03b1-MSH suppressed the majority of GI neurons and excited the majority of GE neurons in the cellular nucleus. One of the 20 GI neurons tested for a reaction to u03b1-MSH was activated in the DVC, 16 were depressed, and three others were delayed, and none failed to respond. In addition, 23 of the 42 DVC neurons tested for responses to GD, 23 were excited and 19 were blocked. Five of 20 GD-EXC neurons were stimulated, but 11 out of 14 GD-INH neurons were blocked by u03b1-MSH. In conclusion, the activity of glucose-sensitive neurons and GD-sensitive neurons in the hypothalamus and DVC can be modulated by u03b1-MSH.

Source link: https://doi.org/10.1155/2017/2034691


Cypress tree (Chamaecyparis obtusa) Bark extract inhibits melanogenesis through repressing CREB and MITF signalling pathways in α-MSH-stimulated B16F10 cells

The bark of Cypress tree bark is well-known for its bio-chemical function and high concentration of polyphenol and flavonoids. The aim of our research was to find the anti-melanogenic effects of Cypress Tree Bark extract's anti-melanogenic activity. In alpha-stimulating hormone-induced B16F10 murine melanoma cells, we investigated cell tyrosinase activity and melanin levels. Using western blot analysis, we investigated microphthalmia-associated transcription factor, tyrosinase-related protein, and cAMP response element-binding protein inducer activation via phosphorylation of AKT and ERK. In u03b1-MSH-stimulated melanoma cells, stimulated melanoma cells, CBE restored melanin content and tyrosinase activity. In addition, CBE has greatly reduced CREB activation by suppressing AKT and extracellular signal-regulated kinase phosphorylation, which has significantly reduced CREB activation.

Source link: https://doi.org/10.1080/09540105.2022.2095986


Increased Expression of TLR4 in Circulating CD4+T Cells in Patients with Allergic Conjunctivitis and In Vitro Attenuation of Th2 Inflammatory Response by Alpha-MSH

Immunological damage is mediated by a local Th2 inflammatory microenvironment, accompanied by shifts in circulating cell subsets, with more effector cells and fewer T regulatory cells. This research was designed to investigate the role of toll-like receptor 4 and u03b1-melanocyte stimulating hormone in chronic allergic asthma causing immune dysfunction. The percentage of CD4+TLR4+ cells and cytokines IL-4 and IL-6 were significantly reduced when u03b1-MSH was added to the culture, and the number of CD4+CD25+FoxP3+ cells and cytokines IL-4 and IL-6 were both CD25+, with a significant decrease. In tears, we discovered an elevated u03b1-MSH serum in PAC patients, compared to HD. In addition, we established the presence of CD4+TLR4+ cells as an effector cell subtype in ocular allergy.

Source link: https://doi.org/10.3390/ijms21217861

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions