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MMR Vaccine - Crossref

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Last Updated: 01 June 2022

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A phase II study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair–proficient (MMR-p) advanced colorectal cancer.

"Cancer vaccines can help to regulate the tumor microenvironment for anti-PD1 therapy. " Methods: We conducted an open label, single-arm, phase 2 research of GVAX/Cy in combination with the PD1 inhibitor pemiobarb in patients with MMRp CRC who had received at least two prior lines of therapy in the metastatic setting. Patients on day 1, GVAX, a 21-day cycle, were first introduced pembolizumab plus Cy on day 2 and were then commenced on a pembrolizumab maintenance program of pembolizumab every three weeks, with cy/GVAX given every 12 weeks. Anti-CEA antibody titers increased 13 of 13 of 13 patients with available paired pre- and on-treatment lab blood samples, but CEA responders and non-responders were similar, although the change in anti-CEA antibody titers were similar among CEA responders and non-responders. CEA responses were not observed in MMRp CRC's PD1 monotherapy, suggesting that GVAX can modulate the antitumor immune response.

Source link: https://doi.org/10.1200/jco.2019.37.4_suppl.563


Differential Effects of the DTaP and MMR Vaccine Shortages on Timeliness of Childhood Vaccination Coverage

"We established the effects of diphtheria and tetanus toxoids, acellular pertussis vaccine, and rubella vaccine shortages on the timeliness of the third dose of DTaP, the fourth dose of DTaP, and the first dose of MMR among subgroups of preschool children, as the third dose of DTaP and the first dose of MMR. " Those aged 4 to receive DTaP4 during the shortage were less likely to be vaccinated by 19 months of age than children not exposed to the shortage.

Source link: https://doi.org/10.2105/ajph.2004.053306


Poor Uptake of MMR Vaccine 1-year Post-Measles Outbreak: New York City and Israel

"Vaccination data was used to determine vaccination status for measles, mumps, and rubella at the time of measles testing and 1-year post-testing. " Vitamin A was given to only 20 percent of measles-positive patients in a two-dose regimen. At the time of diagnosis, 84% of children with measles were u22651 years old and fully eligible for MMR vaccine, with 80% being 82. 4%. Children in both measles-positive and -negative groups were significantly more likely to have MMR than measles-positive children (74% vs. 37%), and P 25% of children in both measles-positive and -negative groups were unimunized for MMR 1-year post-outbreak.

Source link: https://doi.org/10.1093/jpids/piac026


Decreased humoral immunity to mumps in young adults immunized with MMR vaccine in childhood

The majority of mumps IgG antibodies in our sample of 18- to 23-year-old college students had detectable mumps IgG antibodies by enzyme-linked immunosorbent assay, but the number was smaller than rubella. " Compared to a circulating genotype G mumps strain versus the vaccine strain, neutrtralizing antibody titers were 6-fold lower than the vaccine strain. To mumps, ten percent of our participants had no apparent memory B cells.

Source link: https://doi.org/10.1073/pnas.1905570116


Repurposing Live Attenuated Trivalent MMR Vaccine as Cost-effective Cancer Immunotherapy

"ABSTRACT ACT "ABSTRACT explains the fact that cancer immunotherapy is out of reach for many patients due to the high cost of manufacturing immunotherapy products. We found that MMR aided in the development of immunologically coordinated cancer cells death by using an integrated transcriptomic and proteomic approach.

Source link: https://doi.org/10.1101/2022.02.25.481685


Autism and MMR vaccine

"Autism is a complex developmental disorder with a variety of signs and symptoms. " MMR vaccine may be responsible for autism risk in a long time, according to one of the reasons that have piqued most attention is a potential association between MMR vaccine and autism risk. MMR vaccination coverage increased the risk of autism, according to the study, so MMR immunization coverage in those countries were almost eradicated. New studies denying any association between MMR vaccine and autism risk have been published soon after the initial release. ".

Source link: https://doi.org/10.5937/medist1801014m


Looking in the medicine cabinet: methods for using real-world data to assess the impact of measles, mumps and rubella (MMR) and recombinant adjuvanted varicella-zoster vaccines on coronavirus disease 2019 (COVID-19) prevention and case fatality

"This paper uses real-world data from Cerner Labs in the United States to determine the possibility of two viral vaccines on COVID-19 case fatality rates in the United States. " Methods: We found 373,032 polymerase chase cases in the Cerner Labs database between 01-MAR-2020 and 31-DEC-2020, identifying patients with measles, mumps, rubella, or a recombinant adjuvanted varicella-zoster vaccine within the last five years. Results: Neither the recombinant adjuvanted varicella-zoster vaccine nor MMR showed significant improvement in preventing severe acute respiratory syndrome coronavirus 2 infection. Conclusions: Using propensity score matching and heterogeneity statistics can help guide our interpretation of real-world results, and rigorous statistical techniques are required to eliminate bias or data interpretation in data interpretation. Applying these techniques to the effects of viral vaccinations on COVID-19 case fatalities yields actionable results for further investigation.

Source link: https://doi.org/10.12688/gatesopenres.13329.1


Cross-Sectional Study of University students’ attitudes to ‘on campus’ delivery of COVID-19 vaccines and future-proofing MenACWY and MMR vaccination rates by adopting COVID-19 vaccine roll-out strategies

"We wanted to determine risk factors for vaccine hesitance and opinions of university students about on-campus vaccination delivery. " Methods Cross-sectional anonymous online questionnaire survey of undergraduate students at a British university in June 2021. The hesitancy of COVID-19 vaccine hesitancy was traced to black ethnicity and questions regarding vaccination side-effects. Compared to those who live at home, lower rates of vaccine hesitancy were present amongst students living in private accommodation. For MMR and MenACWY vaccines, uncertainty regarding their personal vaccination status was often present. Conclusions Vaccine hesitancy among students of black ethnicity and those living at home must be investigated further because attitudes in these groups could influence COVID-19 vaccine uptake. Students' MMR and MenACWY vaccination statuses are also a point of concern for these vaccine programs. On-campus vaccination delivery can also increase vaccination uptake, particularly for international students. ".

Source link: https://doi.org/10.1101/2022.02.07.22270394


Efficacy of MMR Vaccine as Intralesional Immunotherapy in Viral Warts

"There are several harmful medications for common warts treatment, but no single therapy has yet to be 100% effective," says the author. Result and Method: A total of 100 patients with viral warts excluding genital warts was selected in this hospital-based prospective study. Patients were followed closely by physicians who had not detected recurrences at various times, and the MMR vaccine was administered at various times, and the patients were followed-ups to those who had found recurrences. Result: The most common warts were Verruca Vulgaris and palmoplantar warts, which were seen in 38. 8% patients each, according to a report by the CDC. In 14. 9 percent subjects and 10. 28% patients, there were verruca planas. In 38. 2 percent of patients and single warts, multiple warts were found in 68. 22% of patients and single warts in 38. 8 percent. Complete response was seen in 76. 6 percent of patients, partial response in 14. 8 percent of patients, and no response in 8. 4 percent of patients. MMR therapy of warts using the intralesional MMR technique appears to be more effective and a safer alternative to traditional destructive techniques. ".

Source link: https://doi.org/10.47363/jdmrs/2021(2)135


Epidemiology of mumps outbreaks and the impact of an additional dose of MMR vaccine for outbreak control in regional Queensland, Australia, 2017–2018

"We set out to define the epidemiology of mumps outbreaks in Central Queensland, Australia, between October 2017 and October 2018, as well as evaluate the effects of an additional dose of measles, mumps, rubella vaccine. Mandatory notifications from the Queensland Health Notifiable Conditions System database and immunization data from the Queensland Health Information and Admin System and the Australian Immunization Register were analyzed by Wean. 93 cases of mumps were recorded in Central Queensland between October 2017 and October 2018, including three distinct outbreaks: a distinct indigenous group; a correctional facility; and a boarding school. Prior to this additional dose of MMR, the mumps attack rate was 31. 0 per 1000 people, down from the previous additional dose MMR attack rate of 10. 6 per 1000 people. ".

Source link: https://doi.org/10.33321/cdi.2021.45.67

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions