Advanced searches left 3/3

Lymphopenia - PubMed

Summarized by Plex Scholar
Last Updated: 26 September 2022

* If you want to update the article please login/register

Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome.

Early progenitor stages of B lymphopenia, but why are CXCR4 GOF mutations that cause B lymphopenia to remain unclear? LT-u03b2R blocking has also reduced the production of IL-7 and B cell activating factor in secondary lymphoid organs, thus increasing B and T cell counts in the periphery. These results showed that LTu03b2R signaling in BM MSCs and SLO stromal cells limits the lymphocyte compartment size, according to these studies.

Source link: https://doi.org/10.1126/sciimmunol.abo3170


IL-6 drives T cell death to participate in lymphopenia in COVID-19.

Six patients were randomly selected to record their changes in T lymphocytes and plasma concentrations of IL-6 for the course of disease, in order to investigate the causes of T cell lymphopenia in the disease. In COVID-19 patients, patients with a T cell count below 200 cells/u03bcL indicate a serious disease. Inferring IL-6 was able to promote T cell reduction by gasderminE-mediated pyroptosis, inferring that IL-6 plays a role in changing T cell function and status in COVID-19 patients.

Source link: https://doi.org/10.1016/j.intimp.2022.109132

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions